Metrogil plus gel vaginas. 50g tube 1 pc + applicator 10 pcs

Description

Composition Active ingredient: 1 g of gel contains: metronidazole 10 mg, 20 mg clotrimazole. Excipients: benzyl alcohol 40 mg disodium edetate 0.50 mg Carbomer-940 10.0 mg methyl parahydroxybenzoate 1.50 mg Sodium hydroxide 2.0 mg propyl parahydroxybenzoate 0.50 mg propyleneglycol 50.0 mg, water ck . des. 1.0 g Description: A homogeneous opalescent gel is white or almost white. Product: Vaginal Gel. – 30 g of an aluminum tube, or a plastic laminated tube, the mouth of which is sealed a membrane of aluminum and polyethylene screw-cap with a projection for perforating the membrane. One tube with an applicator and application instructions in a cardboard box. – 50 g of an aluminum tube, or a plastic laminated tube, whose neck is sealed with aluminum foil, laminated with polyethylene and a polypropylene screw cap with a protrusion (projection or without) for perforation of the foil. One tube in a cardboard box with an applicator and instructions for use. – 50 g of an aluminum tube, or a plastic laminated tube, the mouth of which is sealed with aluminum foil laminated with polyethylene and a polypropylene screw cap with a protrusion (projection or without) for perforation of the foil. One tube in a cardboard box together with applicators in an amount of 10 pieces and instructions for use. Hypersensitivity to the drug. Leukopenia (including history), organic lesions of the central nervous system (including epilepsy), liver failure, the menstrual period. I trimester pregnancy, lactation. Indications Bacterial vaginosis various etiologies confirmed by clinical and microbiological data; candida vulvitis and vulvovaginitis, urogenital trichomoniasis. Interaction with other drugs only for intravaginal use! Similarly, disulfiram is intolerant of ethanol. It enhances the action of anticoagulants is not recommended to combine with the non-depolarizing muscle relaxants (vecuronium bromide). Together with the admission drugs lithium may increase the concentration of lithium in the blood plaza. Phenobarbital accelerates the metabolism of metronidazole due to the induction of hepatic microsomal enzymes, cimetidine – decreases, which may lead to an increase in its concentration in the serum and an increase in the risk of side effects. Amphotericin B, Nystatin, reduce the effectiveness of natamycin, while the application of clotrimazole. Overdose No cases of overdose when administering the drug were observed at recommended doses. The drugs Group: Antimicrobial and protivoprotozoynoe + antifungal agent. Pharmacodynamics: Combined preparation for intravaginal application efficiency which is caused by the presence in its structure of two active components: metronidazole and clotrimazole. The mechanism of action of metronidazole is in the biochemical reduction of 5 – nitro intracellular transport proteins of anaerobic microorganisms and protozoa. The recovered 5 – nitro group of metronidazole interacts with DNA microbial cells by inhibiting synthesis of nucleic acids, which leads to the death of the bacteria. It is active against Trichomonas vaginalis, Entamoeba histolytica, Gardnerella vaginalis, Giardia intestinalis, Lamblia spp., As well as obligate anaerobes Bacteroides spp., (Including Bacteroides fragilis, Bacteroides thetaitaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella (Prevotella bivia, Prevotella buccae, Prevotella disiens) and some gram-positive microorganisms (Eubacterium spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp.) The minimum inhibitory concentration (MIC) for these strains is 0,125-6,25 mg / ml. Insensitive to metronidazole aerobic microorganisms and facultative anaerobes, but in the presence of mixed flora (aerobes and anaerobes) metronidazole acts synergistically with antibiotics effective against common aerobes. Clotrimazole is an imidazole derivative. It has a fungicidal effect. It reduces the synthesis of ergosterol, which is part of the microbial cell membrane wall, and causes a change in its structure and properties. At low concentrations fungistatic effect and large (more than 20 micrograms / ml) – fungicide, not only in proliferating cells. The fungicidal concentrations interacts with mitochondrial and peroxidase enzymes, resulting in increased concentrations of hydrogen peroxide up to a toxic level, which also contributes to the destruction of fungal cells. It is highly active against pathogenic dermatophyte (Trichophyton mentagrophytes, Microsporum canis, Epidermophyton floccosum), yeasts and fungi (the genus Candida, Torulopsis glabrata, genus Rhodotorula, Pityrosporum orbiculare). Pharmacokinetics: After intravaginal metronidazole subjected to systemic absorption (about 56%). Relative bioavailability of a vaginal gel in 2-fold higher bioavailability of a single dose (500 mg) of metronidazole vaginal tablets. Passes into breast milk and most tissues, passes the blood-brain barrier and the placenta. After a single intravaginal administration of 5 grams of gel (50 mg of metronidazole) mean maximum concentration in serum of healthy women is 237 ng / ml, which is 2% of the mean maximum concentration of metronidazole when administered dose of 500 mg. Time to maximum concentration – 6-12 hours. Communication with the plasma protein is less than 20%. It is metabolized in the liver by hydroxylation and oxidation glyukuronirovaniya. Activity of the main metabolite (2-oximetronidazole) – is 30% of the activity of the parent compound. Excreted by the kidneys – 60-8% dose systemic action of the drug (20% of this amount in an unmodified form), intestine – 6-15% of a dose of the drug system. In the application of clotrimazole intravaginally absorbed no more than 3-10% of the administered dose. High concentrations in the vaginal secretions and low concentrations in the blood are retained within 48-72 hours. In the liver, clotrimazole is rapidly metabolized to inactive metabolites. Pregnancy and lactation Use of the drug in the II and III trimester of pregnancy is possible only for health reasons, if the potential benefit to the mother outweighs the risk to the fetus. In appointing the drug during lactation should stop breastfeeding. Conditions of supply of pharmacies by prescription. Side effects Local reactions: itching, burning and redness of the mucous membrane of the external genital organs; in a sexual partner – a burning sensation or irritation of the penis, frequent urination. Perhaps the development of systemic effects: dizziness, headache, dry mouth, altered taste sensations, including “metallic” taste, nausea, vomiting, decreased appetite, cramping abdominal pain, constipation or diarrhea, staining of urine in a dark color, leukopenia or leukocytosis . Allergic reactions: skin rash, urticaria. In case of any adverse side effects should stop treatment and seek medical advice !. Specific guidance is recommended that simultaneous treatment of sexual partners. During the course of treatment should refrain from sexual activity. When vaginitis caused by Trichomonas vaginalis, to the simultaneous treatment of sexual partner metronidazole for oral administration. In the case of the drug in conjunction with metronidazole for oral administration, especially when repeated course, necessary to monitor patterns of peripheral blood (risk of leukopenia). In the period of treatment is contraindicated alcohol intake (development disulfiramopodobnyh reactions: abdominal cramping, nausea, vomiting, headache, a sudden rush of blood to the face). Metronidazole can be immobilized Treponema and lead to false positive test Nelson. Avoid contact with eyes! For information about the possible effects of the drug for medical use on the ability to drive vehicles, drug mechanism does not affect the ability to drive and engage in other potentially hazardous activities, require high concentration and psychomotor speed reactions. Storage conditions at a temperature no higher than 25 C. Do not freeze. Keep out of the reach of children. Dosing and dose Intravaginal. The recommended dose is 5 g (one full applicator), 2 times a day (morning and evening). The course of treatment – 5 days. If necessary, treatment can be repeated after 2 weeks. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist The recommended dose is 5 g (one full applicator), 2 times a day (morning and evening). The course of treatment – 5 days. If necessary, treatment can be repeated after 2 weeks. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist The recommended dose is 5 g (one full applicator), 2 times a day (morning and evening). The course of treatment – 5 days. If necessary, treatment can be repeated after 2 weeks. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist