Metrogil gel vaginas. 10mg / g to 30g z coordinate.

$83.00

Metrogil gel vaginas. 10mg / g to 30g z coordinate.

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SKU: 515511266 Categories: , , Tags: ,

Description

Composition Active ingredient: 1 g of gel contains: 10 mg of metronidazole. Excipients: Propyl parahydroxybenzoate, propylene glycol, carbomer 940, disodium edetate, sodium hydroxide, purified water. Description: Homogeneous Gel colorless to light yellow. Product: Gel Vaginal 1%. – 30 g of an aluminum tube with a protective membrane made of aluminum with polyethylene screw cap with a projection for perforating the membrane. One tube in a cardboard box with an applicator and instructions for use. – 30 g in a plastic laminated tube, sealed with aluminum foil laminated with polyethylene and a polypropylene screw cap. One tube in a cardboard box with an applicator and instructions for use. – 30 g in a plastic laminate tube, sealed with aluminum foil, laminated with polyethylene and with polypropylene screw cap with a projection for perforating the foil. One tube in a cardboard box with an applicator and instructions for use. Hypersensitivity (including nitroimidazole derivatives), leukopenia (including history), impaired coordination of movements, organic lesions of the central nervous system (including epilepsy), hepatic failure. Pregnancy – I trimester, lactation. Dosage 10 mg Indications Bacterial vaginosis various etiologies confirmed by clinical and microbiological data; urogenital trichomoniasis. Interaction with other drugs only for intravaginal use! Similarly, disulfiram is intolerant of ethanol. It enhances the effect of anticoagulants, It is not recommended to combine with the non-depolarizing muscle relaxants (vecuronium bromide). Together with the admission drugs lithium may increase the concentration of lithium in the blood plaza. Phenobarbital accelerates the metabolism of metronidazole due to the induction of hepatic microsomal enzymes, cimetidine – decreases, which may lead to an increase in its concentration in the serum and an increase in the risk of side effects. Overdosing cases of drug overdose in this method of administration was observed. The drugs Group: Antimicrobial and protivoprotozoynoe means. Pharmacodynamics: antiprotozoal and antimicrobial agent, 5-nitroimidazole derivative. The mechanism of action is in the biochemical reduction of 5-nitro group of metronidazole intracellular transport proteins of anaerobic microorganisms and protozoa. The recovered 5-nitro group of metronidazole is reacted with DNA of microbial cells, inhibiting synthesis of nucleic acids, which leads to the death of the bacteria. It is active against Trichomonas vaginalis, Entamoeba histolytica, Gardnerella vaginalis, Giardia intestinalis, Lamblia spp., As well as obligate anaerobes Bacteroides spp. (Including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella (Prevotella bivia, Prevotella buccae, Prevotella disiens) and some Gram-positive microorganisms (Eubacterium spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp. ). MIC for these strains is 0,125-6,25 mg / ml. Insensitive to metronidazole aerobic microorganisms and facultative anaerobes, but in the presence of mixed flora (aerobes and anaerobes) metronidazole acts synergistically with antibiotics effective against common aerobes. Pharmacokinetics after single intravaginal administration of 5 g Metrogila® average maximum serum concentration of the drug – 237 ng / ml, which is 2% of the mean maximum concentration of metronidazole when administered in doses of 500 mg. Time to maximum concentration is 6-12 hours after intravaginal application of a single dose of 5 g After intravaginal drug undergoes systemic absorption (about 56%). It passes into breast milk and most tissues, It passes through the blood-brain barrier and placenta. Communication with plasma proteins – less than 20%. It is metabolized in the liver by hydroxylation and oxidation glyukuronirovaniya. Activity of the main metabolite (2-oximetronidazole) – 30% of the activity of the parent compound. Relative bioavailability of a vaginal gel in 2-fold higher bioavailability of a single dose (500 mg) of metronidazole vaginal tablets, due to the high penetrating power of the drug in the vaginal fluid. Therefore, after the therapeutic effect of intravaginal administration is achieved already at low concentrations of metronidazole. Pregnancy and lactation In II and III trimester of pregnancy – only for health reasons, when comparing the potential benefit to the mother and the potential risk to the fetus. Conditions of supply of pharmacies by prescription. Side effects Local reactions: burning sensation or frequent urination, vulvitis; in a sexual partner – a burning sensation or irritation of the penis. After discontinuation of the drug – the development of vaginal candidiasis. Perhaps the development of systemic effects: dizziness, headache, dry mouth, altered taste sensations, including “metallic” taste, nausea, vomiting, decreased appetite, cramping abdominal pain, constipation or diarrhea, staining of urine in a dark color, leukopenia or leukocytosis . Allergic reactions: skin rash, urticaria. In case of any adverse side effects should stop treatment and seek medical advice !. Specific guidance is recommended that simultaneous treatment of sexual partners. During the course of treatment should refrain from sexual activity. When vaginitis caused by Trichomonas vaginalis, to the simultaneous treatment of sexual partner metronidazole for oral administration. In the case of the drug in conjunction with metronidazole for oral administration, especially when repeated course, necessary to monitor patterns of peripheral blood (risk of leukopenia). In the period of treatment is contraindicated alcohol intake (development disulfiramopodobnyh reactions: abdominal cramping, nausea, vomiting, headache, a sudden rush of blood to the face). Metrogil® may be immobilized Treponema and lead to false positive test Nelson. Storage conditions at a temperature no higher than 25 C. Keep out of reach of children. Dosing and dose Intravaginal recommended dose is 5 g (one full applicator), 2 times a day (morning and evening). The course of treatment – 5 days. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

UNIC

Use

infection

Release Form

gel

Active ingredients

metronidazole

Dosage

10 mg

Amount in a package

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