Metrogil gel appearance. 1% 30g tuba

$4.53

Metrogil gel appearance. 1% 30g tuba

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SKU: 01526522969 Categories: , , Tag:

Description

Composition
Active substance:
1 g of gel contains: Metronidazole – 10.0 mg ;.
Excipients:
Disodium edetate – 0.50 mg, carbomer-940 – 10.0 mg, methyl parahydroxybenzoate – 0.32 mg Sodium hydroxide – 1.27 mg propyl parahydroxybenzoate – 0.40 mg propylene glycol – 50.0 mg Purified Water – ck . des. up to 1 year
Description:
Homogeneous gel from colorless to yellow.
Product form:
Gel 1% in ’30
Contraindications
Hypersensitivity to the components within the drug as well as the nitroimidazole derivative.
Dosage
1 %
Indications
Rosacea (including poststeroidnye), acne vulgaris, infectious skin diseases, trophic ulcers of the lower extremities (in the background of varicose veins, diabetes mellitus), vyalozazhivayuschie wounds, pressure sores, burns, eczema, seborrheic dermatitis, oily seborrhea, seborrheic dermatitis , hemorrhoids, anal fissures.
Interaction with other drugs
With simultaneous application enhances the effect of warfarin and other anticoagulants (prothrombin time increases).
Overdose
Cases of drug overdose in recommended dosages for a given route of administration was observed.
pharmachologic effect
Pharmacological group:
Antimicrobial and protivoprotozoynoe means.
Pharmacodynamics:
Antiprotozoal and antimicrobial agent, 5-nitroimidazole derivative. The mechanism of action is in the biochemical reduction of 5-nitro group of metronidazole intracellular transport proteins of anaerobic microorganisms and protozoa. The recovered 5-nitro group of metronidazole is reacted with DNA of microbial cells, inhibiting synthesis of nucleic acids, which leads to the death of the bacteria.
It is active against Trichomonas vaginalis, as well as Gram-negative anaerobes Bacteroides spp. (Including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp. and some gram-positive organisms (sensitive strains of Eubacterium spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp.). MIC for these strains is 0,125-6,25 mg / ml.
When applied topically has antiacne action mechanism of which is not precisely known (not associated with the action on the mite Demodex folliculorum, detectable in the hair follicles and sebaceous gland secretions, and any effect on this secretion products).
Metronidazole for external application may have antioxidant activity. It is found that it significantly reduces the production of neutrophils active oxygen, hydroxyl radicals and hydrogen peroxide which are potent oxidants, able to cause tissue damage at the site of inflammation. Metronidazole is for external use is ineffective against telangiectasias, celebrated at pink acne.
Insensitive to metronidazole aerobic microorganisms and facultative anaerobes, but in the presence of mixed flora (aerobes and anaerobes) metronidazole acts synergistically with antibiotics effective against common aerobes.
Pharmacokinetics:
Suction min, after topical application in the serum are found only trace amounts of the drug. Metronidazole sucked passes through the placenta and blood brain barrier (BBB). Cmax – 66 ng / ml (1 g of the substrate gel equivalent to 7.5 mg of metronidazole).
Pregnancy and breast-feeding
It is not recommended to prescribe a drug to pregnant women in the I trimester of pregnancy.
During the period of lactation, when necessary, the appointment, should decide the issue of termination of breastfeeding.
Conditions of supply of pharmacies
Without recipe.
side effects
When applied topically, metronidazole concentration in the blood is very low, so the risk of systemic side effects is small.
Rarely can be observed: allergic reactions (rash, pruritus, urticaria); hyperemia, scaling and skin burning, tearing (when the gel is applied close to the eyes).
special instructions
Do not apply to eye mucosa or near the eye (may cause tearing).
In the case of gel contact with the eyes, they should be immediately with plenty of water.
The drug does not affect the ability to drive and maintain the moving mechanical equipment.
Storage conditions
Store at a temperature not higher than 30 C. Do not freeze.
Keep out of the reach of children.
Dosing and Administration
For outdoor applications.
Applied on clean skin with a thin layer 2 times a day, morning and evening, for 3-9 weeks. If necessary, an occlusive dressing applied. The average duration of treatment is 3-4 months, the therapeutic effect is usually observed after 3 weeks of treatment.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

UNIC

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