Metadoksil Injection 300mg / 5ml ampoules 10 pcs

Description

Composition
Active substance:
metadoksin 300 mg
Excipients:
Sodium disulfite 5 mg Disodium edetate 0.1 mg Methyl parahydroxybenzoate 2.5 mg water for injection 5 ml.
Description:
Transparent colorless or light yellow liquid.
Product form:
Packing 10 ampoules
Contraindications
hypersensitivity to any component of the drug
Carefully:
– use in Parkinson’s disease when levodopa is used at the same time, because metadoksin reduces the effectiveness of the medication.
– apply people predisposed to bronchial obstruction, particularly bronchial asthma, as sodium metabisulfite, contained in the solution can cause their allergic reactions or amplification asthma attacks.
Dosage
60 mg / ml
Indications
– acute alcohol intoxication;
– alcohol withdrawal syndrome
Interaction with other drugs
In a joint application reduces the effectiveness of levodopa.
Overdose
None known.
pharmachologic effect
Pharmacological group:
treatment for alcoholism.
Pharmacodynamics:
Hepatoprotective effect due metadoksina membrane stabilizing effect and is based on the ability to reduce the ratio of saturated and unsaturated free fatty acids. As a result of this increased stability of the hepatocytes to the action of lipid peroxidation, which occurs under the influence of alcohol toxic agents.
Metadoksina detoxification effect caused by activation of hepatic enzymes involved in ethanol metabolism, which reduces its toxic effects.
Metadoksin prevents the accumulation of triglycerides in the hepatocytes, and prevents the formation of fibronectin and collagen, which significantly slows the formation of cirrhosis.
Metadoksin activates cholinergic and GABAergic neurotransmitter system,
improves the function of thinking and short-term memory in patients suffering from chronic alcoholism,
prevents motor excitation, which is caused by ethanol.
The drug reduces the relief of alcohol withdrawal syndrome, reduces its psychic and somatic symptoms.
Metadoksin has some non-specific anti-depressant and anxiolytic effects.
Pharmacokinetics:
Relationship to plasma proteins – 50%. It is metabolized in the liver to active metabolites – pyridine and pyrrolidone carboxylate. The half-life (T1 / 2) is 40 – 60 minutes.
45 – 50% metadoksina excreted in the urine within 24 hours, 35 – 50% metadoksina excreted in the feces within 96 hours.
Pregnancy and breast-feeding
Use of the drug during pregnancy and breastfeeding is not recommended.
Conditions of supply of pharmacies
Prescription
side effects
Allergic reactions.
In patients suffering from bronchial asthma, bronchospasm may develop.
special instructions
Children up to age 18 years.
Clinical studies in patients have not been conducted in this group. However, in severe cases, acute alcohol intoxication, use of the drug is possible after the evaluation of the patient and the benefit / risk ratio.
Effects on ability to drive vehicles, machinery.
It does not affect the ability to drive vehicles, machinery.
Storage conditions
In the dark place at a temperature not higher than 25 ° C.
Keep out of the reach of children!
Dosing and Administration
Acute alcohol intoxication
300-600 mg (5-10 ml) was intramuscularly or 300 – 900 mg of (5-15 ml) intravenously, depending on the degree of intoxication.
When administered intravenously, the necessary dose is diluted with 500 ml of isotonic sodium chloride solution or 5% dextrose (glucose), and introduced dropwise over 1.5 hours.
Alcohol withdrawal syndrome
900 mg (15 mL) as an intravenous infusion (See above.) Once a day for 3-7 days depending on the condition of the patient.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist