Makmiror complex caps. vaginas. 200000me 500mg + 8 pcs

$20.85

Makmiror complex caps. vaginas. 200000me 500mg + 8 pcs

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Description

Composition Active ingredient: nystatin 200 000 ME + nifuratel 500.0 mg Excipients: AK1000 dimethylpolysiloxane (dimethicone) 960.0 mg Composition of the shell: Gelatin 351.0 mg, glycerin (glycerol) 171.0 mg sodium ethyl parahydroxybenzoate 1.8 mg sodium iropilparagidroksibenzoat 1.0 mg titanium dioxide 0.4 mg iron oxide yellow dye 2.4 mg Description: soft gelatin capsules ovoid yellow brown tint containing a yellow oily suspension. Product: 8 or 12 capsules in blister Al / PVC / PVDC. 1 blister together with instructions for use in a cardboard pack. Hypersensitivity to nifuratel, nystatin or any excipient the formulation. Children up to age 18 years. Dosage 200,000 IU + 500 mg Indications Vulvovaginal infections, caused by sensitive pathogens, including bacterial vaginosis, trichomoniasis of the vagina; vaginitis caused by fungi of the genus of Candida, mixed vaginitis. Interaction with other drugs not identified clinically significant drug interactions Makmiror complex with other drugs. Overdose Cases of overdose have been reported. Pharmacological Therapeutic effect: combined antimicrobial agent (protivoprotozoynoe antimicrobial and antifungal agent +) Code: G01AX Pharmacodynamics: Antimicrobial agent for topical application. It has protivoprotozoynoe, antifungal and antibacterial properties. Nifuratel, nitrofuran derivative. Highly active against a number of bacteria, fungi and protozoa (including Trichomonas vaginalis). Nystatin – antifungal antibiotic polyenes group. By binding to sterols in the cell membrane of fungi, it violates its permeability, which leads to cell death. Highly active against Candida albicans. Nifuratel and nystatin combination allows to achieve a more pronounced antifungal activity and greatly expand the range of antimicrobial action. High efficiency and low toxicity of the components of the drug are responsible for a wide range of its clinical application in the treatment of vaginitis of mixed etiology, in particular the use for the prevention of fungal infections caused by specific treatment of trichomoniasis. Makmiror complex does not violate the physiological flora, thus avoiding the development of dysbiosis and quickly restore normotsenoz vagina. Pharmacokinetics studies confirm, that vaginal application in animals (rabbit and dog) with repeated administration of the daily dose, which is 30 times higher than the therapeutic dose, the substances included in the formulation does not have systemic effects. Studies in humans the pharmacokinetics of the drug is also confirmed that the use of intravaginal drug is practically not absorbed from the surface of the vaginal mucosa and does not have any systemic effects. Nifuratel concentration in plasma below the limit of quantitation. The maximum concentration (Cmax) of 4.54 ng / ml; time to reach maximum concentration (Tmax), 8.0 h; Integrated area under the curve “concentration-time» (AUC) 10,27 ml’1 ng h. Nystatin is not absorbed through the skin and mucous membrane when topically applied. Pregnancy and lactation Use of the drug during pregnancy is possible if the potential benefit to the mother outweighs the risk to the fetus or child. from pharmacy dispensing conditions Prescription Side effects possible allergic reactions such as skin rash or itching. With the development of allergic reactions, use of the drug should be discontinued. Specific guidance is necessary to conduct simultaneous treatment of sexual partners at risk of re-infection. In the period of treatment should avoid sexual contact. Vaginal capsules are not used for the treatment of childhood, as necessary of the drug in these patients use the drug Makmiror complex in the dosage form of a vaginal cream complete with applicator (graded syringe). The presence of a special nozzle allows the introduction of a cream, without damaging the hymen. Effects on ability truck control mechanisms and use of the drug does not affect the ability to drive vehicles and other activities that require attention. Storage conditions in a dry place at a temperature not higher than 25 ° C. Keep out of the reach of children! Dosing and dose Intravaginal 1 vaginal capsule administered daily in the evening before bedtime for 8 days or in accordance with a physician’s recommendations. If necessary, the treatment can be repeated after menses. For maximum effect, enter the capsule deeply in the vagina. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist Effects on ability truck control mechanisms and use of the drug does not affect the ability to drive vehicles and other activities that require attention. Storage conditions in a dry place at a temperature not higher than 25 ° C. Keep out of the reach of children! Dosing and dose Intravaginal 1 vaginal capsule administered daily in the evening before bedtime for 8 days or in accordance with a physician’s recommendations. If necessary, the treatment can be repeated after menses. For maximum effect, enter the capsule deeply in the vagina. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist Effects on ability truck control mechanisms and use of the drug does not affect the ability to drive vehicles and other activities that require attention. Storage conditions in a dry place at a temperature not higher than 25 ° C. Keep out of the reach of children! Dosing and dose Intravaginal 1 vaginal capsule administered daily in the evening before bedtime for 8 days or in accordance with a physician’s recommendations. If necessary, the treatment can be repeated after menses. For maximum effect, enter the capsule deeply in the vagina. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist requires more attention. Storage conditions in a dry place at a temperature not higher than 25 ° C. Keep out of the reach of children! Dosing and dose Intravaginal 1 vaginal capsule administered daily in the evening before bedtime for 8 days or in accordance with a physician’s recommendations. If necessary, the treatment can be repeated after menses. For maximum effect, enter the capsule deeply in the vagina. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist requires more attention. Storage conditions in a dry place at a temperature not higher than 25 ° C. Keep out of the reach of children! Dosing and dose Intravaginal 1 vaginal capsule administered daily in the evening before bedtime for 8 days or in accordance with a physician’s recommendations. If necessary, the treatment can be repeated after menses. For maximum effect, enter the capsule deeply in the vagina. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist 1 vaginal capsule is administered daily in the evening before going to sleep for 8 days or as directed by your doctor. If necessary, the treatment can be repeated after menses. For maximum effect, enter the capsule deeply in the vagina. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist 1 vaginal capsule is administered daily in the evening before going to sleep for 8 days or as directed by your doctor. If necessary, the treatment can be repeated after menses. For maximum effect, enter the capsule deeply in the vagina. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

SI ES SI LTD

Use

infection

Release Form

vaginal capsules

Active ingredients

Nystatin + nifuratel

Dosage

200 000 + 500 IU mg

Amount in a package

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