Loratadine 10mg tabs 10 pcs ozone

Description

Composition
Active substance:
1 tablet contains 10 mg of loratadine ;.
Product form:
Tablets 10 mg. 10 tablets in blisters of PVC film and aluminum foil printed patent. 1, 2 or 3 blisters together with instructions for use in a pile of cardboard.
Contraindications
Hypersensitivity. Pregnancy, lactation, children under 3 years of age.
Be wary – hepatic insufficiency.
Dosage
10 mg
Indications
Seasonal and perennial allergic rhinitis, conjunctivitis, pollinosis, urticaria (including chronic idiopathic), angioedema, allergic pruritic dermatoses; pseudoallergy reactions, allergic reactions to insect stings, pruritus various etiologies.
Interaction with other drugs
Ethanol reduces the effectiveness of loratadine.
Erythromycin, cimetidine, ketoconazole, when combined with loratadine loratadine increase the concentration in plasma, without causing clinical symptoms and without affecting the ECG.
Inductors microsomal oxidation (phenytoin, barbiturates, ziksorin, rifampicin, phenylbutazone, tricyclic antidepressants) reduce the effectiveness of loratadine.
Overdose
Symptoms: drowsiness, tachycardia, headache. In case of overdose should consult a doctor.
Treatment: induction of emesis, gastric lavage, administration of activated charcoal.
pharmachologic effect
Pharmacological group:
Antiallergic agent – H1-histamine receptor blocker.
Pharmacological properties:
Loratadine – blocker H1-histamine receptors (long-acting). Inhibits the release of histamine and leukotriene C4 from mast cells. It prevents the development and facilitates the allergic reactions. It possesses antihistaminic, antiallergic, and protivoekssudativnoe antipruritic effect. It reduces the permeability of capillaries, prevents the development of tissue edema, relieves spasm of smooth muscles. Antiallergic effect developed after 30 minutes, reaching a peak after 8 – 12 hours and lasts for 24 hours does not affect the central nervous system and does not cause addiction (because does not penetrate the blood-brain barrier)..
Pharmacokinetics:
Quickly and completely absorbed in the gastrointestinal tract. Time to maximum concentration – 1.3-2.5 hours; meal slows it for 1 hour. The maximum concentration of the elderly increases by 50%, with alcoholic liver disease depending on the disease severity. Communication with plasma proteins – 97%. It is metabolized in the liver to form the active metabolite descarboethoxyloratadine, with the participation of cytochrome P450 isoenzymes, CYP3A4 and to a lesser extent CYP2D6. The equilibrium concentration of loratadine and metabolite in the plasma is attained on day 5 of administration. It does not cross the blood-brain barrier. The half life of loratadine – 3- 20 hours (mean 8.4), an active metabolite – 8,8-92 hours (mean 28 hours); elderly patients respectively – 6,7-37 hours (mean 18.2 hours) and 11-38 hours (17.5 hours). In alcoholic liver injury increases half-life, depending on the severity of the disease. Excreted by the kidneys and the bile. In patients with chronic renal failure and hemodialysis pharmacokinetics virtually unchanged.
Conditions of supply of pharmacies
Without recipe.
side effects
Adverse events were listed below, when used with a frequency of loratadine met
In adults: headache, fatigue, dry mouth, drowsiness, gastrointestinal disorders (nausea, gastritis), as well as allergic reactions such as rash. In addition, there are rare reports of anaphylaxis, alopecia, hepatic dysfunction, palpitations, tachycardia.
Children rarely: headache, nervousness, sedation.
special instructions
In the period of treatment should refrain from activities potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
In a dry, dark place at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Inside.
Adults and children over 12 years: 10 mg (1 tablet) 1 every day. The daily dose of 10 mg. Babies from 3 to 12 years at 5 mg (half tablets) 1 time per day. The daily dose of – 5 mg. Children weighing more than 30 kg – 10 mg of the drug 1 time per day. The daily dose – 10 mg.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist