Loratadine 10mg tab, quinacrine 30 pc

$5.49

Loratadine 10mg tab, quinacrine 30 pc

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Description

Composition
Active substance:
1 tablet contains: loratadine, calculated as 100% – 10 mg ;.
Excipients:
Lactose monohydrate 110 mg microcrystalline cellulose 75 mg Calcium stearate 2 mg, 3 mg sodium carboxymethyl starch.
Description:
Tablets white or nearly so white color, Valium, with a facet.
Product form:
Tablets 10 mg.
At 7 or 10 tablets in blisters. 1 or 3 blisters together with instructions for use in a stack of cardboard.
Contraindications
Hypersensitivity, lactation, children weighing less than 30 kg, lactose intolerance, lactase deficiency or glucose-galactose malabsorption.
Carefully
Liver failure, pregnancy.
Dosage
10 mg
Indications
Allergic rhinitis (seasonal and perennial), conjunctivitis, pollinosis, urticaria (including chronic idiopathic), angioneurotic edema, pruritic dermatoses; pseudo allergic reactions caused by the release of histamine; allergic reactions to insect bites.
Interaction with other drugs
Erythromycin, ketoconazole, and cimetidine or combined with loratadine loratadine increase the concentration in plasma, without causing clinical symptoms and without affecting the ECG data.
Inductors microsomal oxidation (phenytoin, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) reduce the effectiveness of loratadine.
Loratadine does not increase the alcohol effects on the central nervous system.
Overdose
Symptoms: drowsiness, tachycardia, headache.
Treatment: gastric lavage, administration of activated charcoal. It does not rely on hemodialysis.
pharmachologic effect
Pharmacological group:
Antiallergic agent – H1-histamine receptor blocker.
Pharmacodynamics:
Blocker H1-histamine receptors (long-acting). Inhibits the release of histamine and leukotriene C4 from mast cells. It prevents the development and facilitates the allergic reactions. It has antiallergic, antipruritic, protivoekssudativnoe action. Reduces the permeability of capillaries, prevents tissue swelling, relieves spasms of smooth muscles. Antiallergic effect developed after 30 minutes, reaching a maximum at 8-12 hours and lasts 24 hours. No effect on the central nervous system (because does not penetrate the blood-brain barrier) and is not addictive.
Pharmacokinetics:
Quickly and completely absorbed in the gastrointestinal tract. The time to reach maximum plasma concentration after ingestion of the drug-1.3-2.5 hours; meal slows it down for 1 hour. The maximum concentration of drug in the blood plasma of elderly people increases by 50%, with alcoholic liver disease with increasing severity of disease. Communication with the plasma protein-97%. It is metabolized in the liver to form the active metabolite dezkarboetoksiloratadina involving isoenzyme cytochrome CYP3A4 and to a lesser extent CYP2D6. The equilibrium concentration of loratadine and metabolite in plasma attained at 5 days of administration. It does not cross the blood-brain barrier. The half life of loratadine-3-20 hours (average 8.4), the active metabolite-8,8-92 hours (mean 28 hours); y-pozhilyhpatsientov respectively 6,7-37 hours (mean 18.2 hours) and 11-38 hours (17.5 hours). In alcoholic liver injury half-life is increased in proportion to the severity of disease. Excreted by the kidneys and the bile. In patients with chronic renal failure and hemodialysis pharmacokinetics virtually unchanged.
Pregnancy and breast-feeding
Use during pregnancy is possible only in those cases where the intended benefits to the mother outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding (enters breast milk).
Conditions of supply of pharmacies
Without recipe.
side effects
In adults: headache, fatigue, dry mouth, somnolence, nausea, gastritis, allergic reactions (rash), anaphylaxis, alopecia, hepatic dysfunction, tachycardia.
In children: headache, irritability, sedation.
special instructions
During the period of treatment must be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
In a dry place at a temperature not higher than 25 C.
Keep out of the reach of children.
Dosing and Administration
Inside. Adults and children weighing more than 30 kg -10 mg 1 time per day.
For patients with renal insufficiency or dysfunction of liver initial dose should be 10 mg every other day.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

QUINACRINE INN

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