Loperamide-quinacrine caps. 2mg 20 pc

Description

Composition
Active substance:
1 capsule contains: active substance – 2 mg of loperamide hydrochloride ;.
Excipients:
Lactose (milk sugar), corn starch, colloidal silicon dioxide (Aerosil), talc, magnesium stearate. Capsules Composition: titanium dioxide, dye quinoline yellow, sunset yellow colorant, gelatine.
Description:
Capsules number 4 yellow. Contents of capsules – powder white or white szheltovatym color.
Product form:
2 mg Capsules.
10 capsules in blisters. 1 or 2 blisters together with instructions for use placed in a pile of cardboard.
Contraindications
Hypersensitivity, intestinal obstruction, severe ulcerative colitis, diverticulosis, diarrhea with acute pseudomembranous enterocolitis, dysentery and other infections of the gastrointestinal tract. Pregnancy (1 trimester), lactation, children under 2 years of age (loperamide-Akrikhin capsules are not indicated for children under 6 years).
Carefully
Liver failure.
Dosage
2 mg
Indications
Symptomatic treatment of acute and chronic diarrhea of ​​various origins (allergic, emotional, drug, radiation, with a change in diet and qualitative composition of food, in violation of metabolism and absorption, and as an adjunct in the diarrhea of ​​infectious origin). Regulation of stool in patients with iliostoma.
Overdose
Symptoms: The symptoms of depression of the central nervous system function (stupor, coordination disturbances, drowsiness, pupillary constriction (miosis) increased skeletal muscle tone, respiratory depression), intestinal obstruction.
Treatment: As a specific antidote used naloxone. Given that the duration of Loperamide-Akrikhin greater than that of naloxone, may re-introduction of the latter. Symptomatic treatment: gastric lavage, administration of activated charcoal (in the first 3 hours after drug administration), artificial ventilation.
pharmachologic effect
Pharmacological group:
Antidiarrheals.
Pharmacodynamics:
Loperamide by binding with opioid receptors of the intestinal wall (stimulation of cholinergic and adrenergic neurons via guanine nucleotides) and reduces the tonus of the smooth muscle of the intestine motility (by inhibiting the release of acetylcholine and prostaglandins). Slows peristalsis and increases the passage of intestinal contents. It increases anal sphincter tone, helps keep feces and deceleration urge to defecate. The action develops quickly and lasts 4-6 hours.
Pharmacokinetics:
The ingestion absorption is 40%. Maximum plasma concentration is reached after 2.5 hours after ingestion of capsules. Communication with plasma proteins (mainly albumin) – 97%. It does not cross the blood-brain barrier. Almost completely metabolized by the liver by conjugation. The half-life – 9-14 hours (mean 9.8 hours). Excreted mainly in the bile, a small portion excreted by the kidneys (in the form of conjugated metabolites).
Conditions of supply of pharmacies
Without recipe.
side effects
There is, as a rule, only during chronic administration of the drug.
Allergic reactions (rash), drowsiness, dizziness, hypovolemia, electrolyte disturbances, dry mouth, intestinal colic, gastralgia, vzhivote pain or discomfort, nausea, vomiting, flatulence.
Rarely – urinary retention, rarely – ileus.
special instructions
If no effect after 2 days of application Loperamide-Akrihin® necessary to clarify the diagnosis and exclude infectious genesis diarrhea.
Children under 6 years of age is not recommended in capsules.
If the treatment develop constipation or bloating, loperamide-Akrikhin should be abolished. Patients with impaired hepatic function should be closely monitored signs of toxic damage to the central nervous system. During treatment of diarrhea need to replenish lost fluids and electrolytes.
At the time of treatment must be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
In a dry, dark place at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Inside, not liquid, wash down with water.
Adults with acute diarrhea initially administered two capsules (4 mg) Loperamide-Akrikhin, then 1 capsule (2 mg) after each defecation in the case of liquid stool. The highest daily dose – 8 capsules (16 mg).
In chronic diarrhea adults appoint 4 mg / day. The maximum daily dose of -16 mg.
In acute diarrhea children over 6 years administered in an initial dose of 2 mg followed by 2 mg after each act of defecation in the case of liquid stool. The maximum daily dose – 4 capsules (8 mg).
In chronic diarrhea for children older than 6 years loperamide-Akrikhin administered in a daily dose of 2 mg. The maximum daily dose of 6 mg per 20 kg.
After normalization of stool or chair in the absence of more than 12 hours reception preparation should be discontinued.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist