Lokoid cream naruzhn.prim-I 0.1% 30g tube

Description

Composition
Active substance:
Hydrocortisone butyrate – 1.0 mg
Excipients:
cetostearyl alcohol – 72 mg, macrogol cetostearyl ether 25 – 18 mg of liquid paraffin – 60
mg, white soft parafin- 150 mg, propyl parahydroxybenzoate – 1.0 mg butyl parahydroxybenzoate – 0.5 mg anhydrous citric acid – 4.2 mg, sodium citrate anhydrous – 2.8 mg Purified water to 1 g
Description:
uniform cream white.
Product form:
Cream for external use of 0.1%.
30 g of cream was placed in an aluminum tube with an aluminum membrane and the screw cap of high density polyethylene.
1 tube together with instructions for use placed in a cardboard box.
Contraindications
– hypersensitivity to hydrocortisone or auxiliary ingredients.
– bacterial infection of the skin (streptoi stafilodermii, gram negative folliculitis, etc.)
– viral skin infections (herpes simplex, chicken pox, shingles, etc.)
– fungal infection of the skin;
– tubercular and syphilitic lesions of the skin;
– parasitic skin infection;
– neoplastic skin lesions (benign and malignant tumors);
– acne, rosacea, perioral dermatitis;
– post-vaccination period;
– violation of integrity of the skin (wounds, ulcers);
– Children up to age 6 months.
Precautions: Pregnancy, lactation.
Dosage
0.1%
Indications
Superficial, non-infected, sensitive to local glucocorticosteroids skin diseases:
– dermatitis, including atopic, contact, seborrheic;
– eczema;
– psoriasis.
If necessary, please consult your physician before using the drug.
Interaction with other drugs
Drug interactions with other drugs is not revealed.
Overdose
Acute overdose is highly unlikely, however, when using the drug in large areas of the affected skin with enhanced ability to resorption over time or with use of occlusive dressings can be chronic overdose accompanied by signs of Cushing: hyperglycemia, glycosuria, reversible depression of adrenocortical function, a manifestation of Cushing’s syndrome -Kushinga.
Treatment: symptomatic, if necessary vodnoelektrolitnogo balance correction, removal of the drug (for long-term therapy – gradual elimination).
pharmachologic effect
Pharmacological group:
glucocorticosteroid for topical application.
Pharmacodynamics:
Hydrocortisone – Lokoid® is the active substance formulation. Lokoid® is a synthetic non-halogenated glucocorticosteroid for external application. Esterification molecule hydrocortisone residue butyric acid (butyrate) afforded radically improve drug activity as compared to native hydrocortisone. Lokoid® has rapidly occurring anti-inflammatory,
anti, antipruritic effect.
Use of the drug at the recommended doses Lokoid® not cause suppression of the hypothalamic-pituitary-adrenal system.
Although the use of high doses for long periods, especially when using occlusive dressings may lead to an increase in cortisol in the blood plasma, it is not usually accompanied by a decrease in reactivity gipofizarnonadpochechnikovoy system, and removal of the drug leads to rapid normalization of cortisol production.
Pharmacokinetics:
Suction
After application of the active substance accumulation in the epidermis, mainly in the granular layer, systemic absorption is negligible. A small amount of hydrocortisone 17-butyrate is absorbed into the systemic circulation in an unchanged form.
Metabolism
Most of hydrocortisone 17-butyrate, hydrocortisone and metabolized to other metabolites directly in the epidermis and subsequently in the liver.
breeding
Metabolites and a small portion of unchanged hydrocortisone 17-butyrate is excreted by the kidneys and through the intestines.
Pregnancy and breast-feeding
Pregnancy
Safety of application of hydrocortisone during pregnancy and lactation has not been studied.
Glucocorticosteroids cross the placental barrier. Avoid long-term treatment and the use of large doses during pregnancy due to the risk of negative impact on fetal development.
Breastfeeding
Glucocorticosteroids are excreted in breast milk. In the case where it is assumed glucocorticosteroid application in large doses and / or for a long time,
should stop breastfeeding.
Before applying Lokoid® medication if you are pregnant or suspect that you might be pregnant, or planning to become pregnant, during breast-feeding should consult a doctor.
Conditions of supply of pharmacies
Without a prescription.
side effects
The frequency of occurrence of adverse reactions
Classification side reactions organs and systems indicating the frequency of occurrence: very often (> 1/10), often (> 1/100
special instructions
If there are signs of hypersensitivity or skin irritation associated with the use of the drug should stop treatment and seek medical advice.
In long-term treatment with the drug applied to the vast surface of the skin, with the use of occlusive dressings, as well as children can be systemic absorption glucocorticosteroid; possible suppression of the hypothalamic-gipofizarnonadpochechnikovoy system and the development of Cushing’s symptoms.
On the face more often than on other surfaces of the body, after long-term treatment of topical corticosteroids may appear atrophic changes; treatment in this case should not exceed 5 days.
Be careful when applying the product to the face, the folds, the area of ​​natural folds in the areas with thin skin.
Avoid getting product in eyes. Does not cause the drug to the mucous membranes.
Keep in mind that steroids are capable of changing manifestations of certain skin diseases, which may hinder the diagnosis. Furthermore, the use glyukokortikostroidov may cause delays wound healing.
When long-term therapy with glucocorticosteroids sudden cessation of treatment can lead to the development of rebound syndrome, manifested in the form of dermatitis with intense redness and burning sensation. Therefore, after long-term treatment abolition of the drug should be gradual, e.g., switching to intermittent treatment regimen before it is completely stopped.
Cetostearyl alcohol, part of the drug may cause irritation at the site of application.
Propyl can cause allergic reactions (possibly delayed type). In such cases, you should stop using the product.
Pediatric use
Lokoid® drug can be used in children from 6 months. Be aware that small children skinfolds, nappies, can have an effect similar to the effect of occlusive dressings, and increase systemic glucocorticosteroid resorption.
Furthermore, children can have a greater degree of systemic resorption because of the relation between the surface skin and body weight, as well as due to insufficient skin maturity. Long-term treatment of children glucocorticosteroid may impair their growth and development. Therefore, long-term use of the drug should be under the supervision of a physician.
Children should receive the minimum dose sufficient to achieve the effect.
In children, treatment should not exceed 7 days.
Effects on ability to drive and use machines
on the impact of data Lokoid® drug on ability to drive and work with no mechanisms.
Storage conditions
At temperatures above 25 ° C.
Do not freeze.
In the reach of children.
Dosing and Administration
Outwardly.
Lokoid® cream is preferably used for acute and subacute cutaneous processes (without soak).
The drug is applied to the affected areas of the skin with a thin layer not more than 2 times per day.
To improve the penetration of drug applied massaging movements. When the positive dynamics in the multiplicity of the drug can be reduced to 2-3 times a week.
The dose of the drug used during the week should not exceed 30-60 g
In the case of flow-resistant diseases, such as dense localization psoriatic plaques on the elbows, knees, the drug can be used under occlusive dressings.
The course of drug treatment in adults – up to 4 weeks. In children, treatment should not exceed 7 days.
If after treatment there is no improvement or there are new symptoms, you should consult with your doctor.
Use drug only according to the application and in those doses which are specified in the instruction.
If necessary, please consult your physician before using the drug.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist