Description
Composition
Active substance:
1 tablet contains: glyukozaminilmuramildipeptid (GMDP) – 10.0 mg.
Excipients:
Lactose monohydrate – 184.7 mg, sugar (sucrose) – 12.5 mg potato starch – 40 mg, methylcellulose – 0.3 mg Calcium stearate – 2.5 mg.
Description:
Round Valium tablets of white color with a facet and Valium.
Product form:
Tablets of 10 mg.
10 tablets in blisters made of PVC film and aluminum foil printed patent. 1 contour cellular packaging together with instructions for medical application is placed in a pile of cardboard.
Contraindications
Hypersensitivity to glyukozaminilmuramildipeptidu and other ingredients; Pregnancy and lactation; children under 18 years of age; autoimmune thyroiditis exacerbation; state, accompanied by febrile temperature (> 38 ° C) at the time of taking the drug; rare inborn errors of metabolism: alaktaziya, galactosemia, lactase deficiency, lactose intolerance, lack of sucrase / isomaltase, fructose intolerance, glucose-galactose malabsorption; application in autoimmune diseases is not recommended due to lack of clinical data.
Carefully:
Likopid® 10 mg used with caution in the elderly, is strictly under medical supervision.
Dosage
10 mg
Indications
The drug used in adults in the treatment of diseases accompanied by secondary immunodeficiency – acute and chronic suppurative inflammatory diseases of the skin and soft tissues, including septic purulent post-operative complications; – infection, sexually transmitted diseases (human papillomavirus infection, chronic trichomoniasis); – herpes infection (including ophthalmoherpes); – psoriasis (including psoriatic arthritis); – pulmonary tuberculosis;.
Interaction with other drugs
The preparation increases the effectiveness of antimicrobial agents, there is synergy with antiviral or antifungal agents. Antacids and sorbents significantly reduce the bioavailability of the drug. Glucocorticosteroids Likopida® reduce the biological effect.
Overdose
Cases of overdose are unknown.
Based on the pharmacological properties of the drug, in the case of overdose can be observed rise in body temperature to subfebrile (up to 37,9 ° C) values. If necessary the symptomatic therapy (antipyretics) are assigned sorbents. A specific antidote is not known.
pharmachologic effect
Pharmacological group:
Immunomodulatory agent.
Pharmacological properties:
The active substance pellets Likopid® – glyukozaminilmuramildipeptid (GMDP) – is a synthetic analogue of structural fragment membranes (peptidoglycan) bacterial cells. GMDP is an activator of the innate and acquired immunity, increases the body’s defense against viral, bacterial and fungal infections; providing adjuvant effect in the development of immunological reactions.
Biological activity of the preparation is realized by binding to an intracellular receptor GMDP protein NOD2, localized in the cytoplasm of phagocytes (neutrophils, macrophages, dendritic cells). The preparation stimulates the functional (bactericidal, cytotoxic) activity of phagocytes, enhances the presentation of antigens, proliferation of T and B lymphocytes, increases the synthesis of specific antibodies helps to normalize balance of Th1 / Th2-lymphocytes in the predominance of Th1. Pharmacological action performed by the gain generating key interleukins (interleukin-1, interleukin-6, interleukin-12), tumor necrosis factor alpha, interferon gamma, colony stimulating factors. The drug increases the activity of natural killer cells.
Likopid® low toxicity (LD50 greater than therapeutic dose of more than 49 000 times). In the experiment, the oral route of administration at doses 100 times exceeding the therapeutic one, the drug has no toxic effect on the central nervous and cardiovascular systems, does not cause the pathological changes of the internal organs. Likopid® has no embryotoxicity or teratogenic effects, does not cause chromosome, gene mutations. In experimental studies conducted on animals, provided data on the antitumor activity Likopida® (GMDP).
Pharmacokinetics:
The bioavailability of the drug when orally reception is 7-13%. The degree of binding to albumin blood weak. The time to reach maximum concentration (tmax) – 1,5 hours after reception. The half-life (t1 / 2) – 4.29 hours. Active metabolites does not form, derived mainly via the kidneys in unchanged form.
Conditions of supply of pharmacies
Prescription.
side effects
Often (1-10%) – arthralgia (joint pain), myalgia (muscle pain); early treatment can be observed a transient increase in body temperature to subfebrile values (up to 37,9 ° C) that is not an indication to remove the drug. In most cases, the above-described side effects observed upon receiving Likopid® tablets at high doses (20 mg).
Rarely (0.01-0.1%) – transient increase in body temperature to febrile values (> 38,0 ° C). With an increase in body temperature over 38,0 ° C can receive antipyretics that does not diminish the pharmacological effects Likopid® tablets.
Very rare (less than 0.01%) – diarrhea.
If any of these instructions side effects are compounded, or if you notice any other side effects not mentioned in the instructions, inform your doctor.
special instructions
Each tablet contains 10 mg Likopid® sucrose in an amount of 0.001 HE (Bread units) that patients should be considered diabetic.
Each tablet contains 10 mg Likopid® 0.184 grams lactose, which should be considered for patients suffering hypolactasia (lactose intolerance, in which the body is observed decline in lactase – enzyme necessary for digesting lactose).
At the beginning of the reception Likopida® 10 mg possible aggravation of symptoms of chronic and latent-occurring diseases associated with the major pharmacological effects of the drug.
In the elderly Likopid® 10 mg used with caution, strictly under medical supervision. Elderly patients are recommended to begin treatment with the half dose (half the therapeutic), the absence of side effects, increasing the dose of the drug to the desired therapeutic.
Decision on use of the drug of 10 mg tablets Likopid® patients with a combination of diagnoses “psoriasis” and “gout,” must take physician in assessing the risk / benefit ratio, due to the presence of potential risk acute gouty arthritis and joint swelling. Should the physician solutions appointing Likopid® 10 mg tablets in combination situation patient diagnoses “psoriasis” and “gout,” treatment should begin with low doses, with no adverse effects, increasing the dose to therapeutic.
Effects on ability to drive vehicles, mechanisms:
It does not affect the ability to drive and complex mechanisms.
Storage conditions
In a dry place, protected from light at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Likopid® administered orally on an empty stomach, 30 minutes before a meal.
Elderly patients are recommended to begin treatment with the half dose (half the therapeutic), the absence of side effects, increasing the dose of the drug to the desired therapeutic.
At the admission of the drug if it has been less than 12 hours from the scheduled time, you can take the missed dose; in the case if more than 12 hours on a scheduled reception time, it is necessary to take only the following scheme dose not accept skipped.
Pyo-inflammatory diseases of the skin and soft tissues, acute and chronic, severe course, including purulent septic postoperative complications: 1 to 10 mg once a day for 10 days;
Herpes infection (recurrent course, severe): 10 mg 1 time per day for 6 days; – at oftalmogerpese: 10 mg 2 times a day during 3 days. After a break of 3 days, repeat the treatment.
Infections, sexually transmitted infections (HPV infection, chronic trichomoniasis): with papillomavirus infection: 10 mg 1 time per day for 10 days in chronic trichomoniasis: 10 mg 1 time per day for 10 days.
Psoriasis: 10-20 mg 1 time a day for 10 days and then five receptions in a day 10-20 mg 1 time per day.
In severe and extensive lesions of psoriasis (including psoriatic arthritis): 10 mg 2 times a day for 20 days.
Pulmonary tuberculosis: 10 mg 1 time per day for 10 days.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist
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