Lamisil uno external solution. 4ml 1% fl

Description

Composition
Active substance:
1 g of solution contains: terbinafine hydrochloride 11.25 mg, which corresponds to a content of 10 mg terbinafine
Excipients:
acrylic acid copolymer and octylacrylamide (Dermakril 79) – 50 mg Medium chain triglycerides – 50 mg, giproloza – 25 mg, 96% ethanol – 863.75 mg.
Description:
A solution for external use 1% of a film forming a transparent or slightly opaque, viscous, colorless to light yellow color, with an ethanol odor.
Product form:
4 g – laminated tube (1) to the control system of the first opening – packings Valium planimetric (1) – packs cardboard with a “window”.
Contraindications
Increased sensitivity to the drug.
Dosage
1 %
Indications
Mycosis (dermatophytosis) stop (tinea pedis).
Interaction with other drugs
Currently, drug interactions terbinafine Uno not known.
Overdose
No cases of overdose have been reported. Overdosing is unlikely, because the drug is released in an amount necessary for a single application and is intended for outdoor use. Symptoms: When accidentally taking the drug orally possible headache, nausea, epigastric pain and dizziness. Treatment: The purpose of the activated carbon, if necessary symptomatic therapy in the hospital.
pharmachologic effect
Pharmacological group:
D01AE15
Pharmacodynamics:
Antifungal agent for external application, with a broad spectrum of antifungal activity. At low concentrations of terbinafine has fungicidal activity against dermatophytes (Trychophyton rubrum, Trychophyton mentagrophytes, Trychophyton verrucosum, Trychophyton violaceum, Trychophyton tonsurans, Microsporum canis, Epidermophyton floccosum), mold (mainly Candida albicans) and certain dimorphic fungi (Pityrosporum orbiculare). Activity against yeast fungi, depending on their type, may be a fungicidal or fungistatic. Terbinafine specifically alters the early stage of the biosynthesis of sterols, occurring in fungi. This leads to a deficiency of ergosterol and to an intracellular accumulation of squalene, which causes death of fungal cells. Action terbinafine accomplished by inhibition of the enzyme squalene epoxidase located on the cell membrane of the fungus. Squalene epoxidase is not associated with the cytochrome P450 system. Terbinafine does not influence the metabolism of hormones or other drugs.
Pharmacokinetics:
After application of terbinafine Uno skin imperceptible solution forms a transparent film which remains on the skin for 72 hours from the film terbinafine quickly penetrates into the stratum corneum:. 60 min after the procedure 16-18% of applied dose found in the stratum corneum. The release terbinafine is progressive in nature, the active ingredient is present in the horny layer after 13 days at a concentration exceeding the minimum inhibitory concentration of terbinafine in vitro against dermatophytes. Systemic bioavailability is very low. When applied topically absorption preparation less than 5%. Uno terbinafine has negligible systemic exposure. relapse rate after 3 months of the drug is low (not higher than 12.5%).
Pregnancy and breast-feeding
Clinical experience with terbinafine Uno for external use in pregnancy is very limited, the drug should be used only on strict conditions. Terbinafine is excreted in breast milk, so the drug should not be administered to nursing mothers. In experimental studies, the teratogenic properties of terbinafine is not revealed. To date, no reports of any malformations in the application of terbinafine Uno.
Conditions of supply of pharmacies
Without recipe
side effects
Side effects are very rare, mild and are short-lived. Systemic reactions: very rarely (1/1000,
special instructions
Terbinafine Uno not recommended for use in chronic plantar hyperkeratosis induced by Tinea pedis (moccasin type). Terbinafine Uno is designed for external use only. The drug should not be applied on the skin, it can cause eye irritation. In case of accidental contact with them must be thoroughly rinsed with running water in the eye. The drug should not be taken internally!
In the case of an allergic reaction to the drug film to be removed by organic solvent (e.g., denatured alcohol), and then rinsed with water and soap foot. With the development of allergic reactions need to remove the drug. the treated area should not be to achieve the best results wash within 24 hours after the procedure. Therefore Uno terbinafine is recommended to apply after taking a shower or bath, and again the next day to wash the feet at the same time. Use this amount of drug that will be required for applying the film on both feet, by performing the above procedure to procedure. The unused remainder of the drug should be destroyed. Improvement of clinical symptoms usually occurs within a few days. If after a week no signs of improvement, it is necessary to verify the diagnosis. There is no evidence that the treatment of elderly patients require correction of dosing regimen, there are other side effects than younger patients. Use in Pediatrics The drug terbinafine Uno in pediatric patients has not been studied. Therefore, it is not recommended to use the drug in children under the age of 15 years. Effects on ability to drive vehicles and mechanisms in the external application of terbinafine Uno does not affect the ability to drive vehicles or perform work with mechanisms.
Storage conditions
The drug should be stored in reach of children, in the original package, at a temperature not higher than 30 ° C.
Dosing and Administration
The preparation is applied topically once. Adults and adolescents over the age of 15 years, the film-forming solution is applied terbinafine Uno 1 times on both feet, even if fungal infection is observed only on one foot. This ensures the destruction of fungi (dermatophytes) that may be present in areas of the foot where the lesion is not visually noticeable. Before applying the drug should wash and dry your feet and hands. It is first treated with one foot, then the other. Starting procedure on interdigital areas should apply a thin layer evenly between the fingers and around their entire surface and also on the sole side of the foot and a height of 1.5 cm. Use a sufficient amount of the drug required to cover the skin surface, usually 1/2 tubes for the processing of each foot. In the same way, and should be treated with the other foot, even if the skin looks healthy to her. Dry the solution over a period of 1-2 min before film formation. After processing stop must wash their hands. Do not apply the drug again in the treated skin. Uno terbinafine should not be rubbed into the skin.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist