Lamisil cream appearance. 1% 30g tuba

Description

Composition
Active substance:
1 g of cream contains: terbinafine hydrochloride 10 mg
Excipients:
benzyl alcohol, sodium hydroxide, sorbitan stearate, cetyl palmitate, stearyl alcohol, cetyl alcohol, polysorbate 60, isopropyl myristate, purified water.
Description:
Cream for external use of white, homogeneous or almost homogeneous, smooth, with a faint characteristic odor.
Product form:
30 ml – vials of high density polyethylene (1) with a tip spray – packs cardboard.
Contraindications
Increased sensitivity to terbinafine or any of the inactive ingredients included in the formulation; breastfeeding; Children up to age 12 years
Dosage
1 %
Indications
Prevention and treatment of fungal skin infections: tinea pedis (tinea pedis); cornification, cracking, itching and flaking of the skin caused by a fungus of the foot; jock itch (tinea craris), fungal skin smooth body (tinea corporis), caused by dermatophytes such as Trichophyton (including T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophyton floccosum; yeast infections of the skin, mainly those caused by fungi of the genus Candida (e.g., Candida albicans), in particular diaper rash; pityriasis versicolor (Pityriasis versicolor), caused by Pityrosporum orbiculare (Malassezia furfur).
Interaction with other drugs
Currently terbinafine drug interactions is unknown.
Overdose
Cases of overdose of terbinafine have been reported. Symptoms: random ingestion 30ml spray containing terbinafine with 300 mg terbinafine hydrochloride comparable with taking 1 tablet of terbinafine at a dosage of 250 mg (single dose for adult humans). If you accidentally receive a larger number of terbinafine spray inside you can expect the same side effects as an overdose of terbinafine tablets (headache, nausea, epigastric pain and dizziness). It should also be noted that spray contains ethyl alcohol (28.87% (v / v) Treatment:…, Activated charcoal, symptomatic therapy if necessary.
pharmachologic effect
Pharmacological group:
D01AE15
Pharmacodynamics:
Antifungal agent for external application, with a broad spectrum of antifungal activity. At low concentrations of terbinafine has fungicidal activity against dermatophytes (Trychophyton rubrum, Trychophyton mentagrophytes, Trychophyton verrucosum, Trychophyton violaceum, Trychophyton tonsurans, Microsporum canis, Epidermophyton floccosum), mold (mainly Candida albicans) and certain dimorphic fungi (Pityrosporum orbiculare). Activity against yeast fungi, depending on their type, may be a fungicidal or fungistatic. Terbinafine specifically alters the early stage of the biosynthesis of sterols, occurring in fungi. This leads to a deficiency of ergosterol and to an intracellular accumulation of squalene, which causes death of fungal cells. Action terbinafine accomplished by inhibition of the enzyme squalene epoxidase located on the cell membrane of the fungus. Terbinafine has no effect on cytochrome P450 system in humans and, accordingly, the metabolism of hormones or other drugs.
Pharmacokinetics:
When applied topically absorption of less than 5% has little systemic effect.
Pregnancy and breast-feeding
Since clinical experience with terbinafine cream in pregnant women is very limited, it should not be used unless absolutely necessary. In pregnancy, the drug is used only if the expected benefit to the mother outweighs the potential risk to the fetus. It is necessary to consult with your doctor. teratogenic properties of terbinafine have been identified in experimental studies. To date, no reports of any malformation when using terbinafine. Terbinafine is excreted in breast milk, so the drug should not be administered to nursing mothers. Do not allow contact with the baby any skin surface treated with terbinafine.
Conditions of supply of pharmacies
Without recipe
side effects
Determining the frequency of side effects (WHO): very common (> 1/10), common (> 1/100 and
special instructions
Reducing the severity of the clinical manifestations usually noted in the first days of treatment. In the case of irregular use or premature termination are at risk of recurrent infection. The drug is intended for external use only. Avoid exposure of drug in the eye, as it can cause irritation. In case of accidental contact with eyes, immediately rinse with running water, and in the case of persistent phenomena of irritation, seek medical advice. With the development of allergic reactions need to remove the drug. Terbinafine cream for external use comprising cetyl and stearyl alcohols, which might cause a local application of local allergic reactions (contact dermatitis). Caution must be exercised when applying spray terbinafine on damaged skin because ethanol, included in its composition, can cause irritation. Terbinafine spray intended for external use only. You should not use terbinafine spray for application to the skin. If terbinafine spray was accidentally introduced into the respiratory tract by inhalation, that in case of any symptoms, and especially when they are persistent preservation, it is necessary to consult a doctor. Terbinafine spray contains propylene glycol, which in some cases can cause skin irritation. It should also be borne in mind that the preparation contains 96% ethanol. Effects on ability to drive vehicles and mechanisms are not affected.
Storage conditions
The drug should be kept out of reach of children at a temperature not higher than 30 ° C.
Dosing and Administration
In adults and children older than 12 years can be applied terbinafine cream 1 or 2 times / day, depending on the evidence. you must thoroughly clean and dry the affected area before applying the medication. The cream is applied thinly to the affected skin and surrounding areas and gently rub. For infections involving intertrigo (under the breasts, interdigital spaces, between the buttocks, groin) cream application site can cover the gauze, especially at night. With extensive fungal infections of the body is recommended to apply the cream in tubes of 30 g average duration of treatment and frequency of use of the drug in tinea of ​​the body, legs is 1 week, 1 time / day; with Tinea pedis – 1 week, 1 time / day; at cornification, cracking, peeling the skin and itching caused by the fungus of the foot – 2 weeks 1-2 times / day; in skin candidiasis – 1-2 weeks 1-2 times / day; with multi-colored lichen – 2 weeks 1-2 times / day. Reducing the severity of the clinical manifestations usually noted in the first days of treatment. With irregular use or premature discontinuation of treatment there is a risk of renewed infection. If there is no sign of improvement after 1-2 weeks of therapy should be to verify the diagnosis. Correct dosing of terbinafine cream regimen in elderly patients is not required.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist