Laksigal yelling drops. 10ml vial

Description

Composition
Active substance:
1 ml of solution contains: sodium picosulphate monohydrate (in terms of 100% substance) 7.50 mg ;.
Excipients:
Sorbitol liquid 70% uncrystallized 680.0 mg, sodium ethyl parahydroxybenzoate 0.66 mg, 35% hydrochloric acid to the desired amount of water to 1 ml.
Description:
Transparent colorless or weak yellowish brownish liquid.
Product form:
Drops for oral administration of 7.5 mg / ml. 10 ml or 25 ml of the product placed in brown glass vial equipped with a dropper cap and the control of the first opening. 1 vial together with instructions for use placed in a cardboard box.
Contraindications
Hypersensitivity to sodium picosulphate, triarilmetanu, parabens and other ingredients, ileus, strangulated hernia, appendicitis, peritonitis, acute inflammatory diseases of the abdominal cavity, including pancreatitis and acute enterocolitis, gastro-intestinal and uterine bleeding, abdominal pain of unknown origin , nausea, vomiting of unknown origin, cystitis, severe dehydration, spastic constipation, condition pocle operations on the abdominal organs, pregnancy I trimester, during breastfeeding, d etsky age under 4 years old.
Carefully
Children older than 4 years.
Indications
Constipation various etiology resulting from hypotension and sluggish bowel motility.
Interaction with other drugs
Broad-spectrum antibiotics reduced laxative effect; diuretics and corticosteroids increase the risk of water and electrolyte imbalance; possible increased sensitivity to cardiac glycosides.
Overdose
Symptoms: See “Side effects”, as well as paroxysmal abdominal pain, ischemia of the colon mucosa, hyperaldosteronism, urolithiasis, renal tubular damage..
Treatment: gastric lavage, correction of fluid and electrolyte balance, antispasmodics.
pharmachologic effect
Pharmacological group:
Laxative.
Pharmacodynamics:
Sodium picosulphate – laxative. Lipophilic active metabolite sodium picosulphate binds to receptors on the intestinal wall, blocking water and electrolyte absorption and increases their secretion into the intestinal lumen, resulting in enhanced peristalsis promoting accelerated intestinal contents. Clabitelnoe effect occurs within 10-12 hours after administration.
Pharmacokinetics:
Sodium picosulphate as the hydrophilic substance is practically not absorbed through the lipophilic membrane of the intestinal cells. Therefore after ingestion sodium picosulphate relatively rapidly it passes through the stomach and small intestine in unaltered form. Approximately 70% of the dose enters the colon after 3 hours after administration. In the large intestine, by hydrolysis with sodium picosulphate influenced by intestinal microorganisms lipophilic active metabolite formed, which easily penetrates through biological cell membranes, stimulating neuroreceptors colonic mucosa membranes. After 12 hours after dosing, only 8% of the administered dose remained in the colon. Within 72 hours 21% of the active metabolite eliminated via the kidneys and 72% – in the intestine.
Pregnancy and breast-feeding
In II and III trimester of pregnancy, the drug can be taken only in cases where the potential benefits of therapy for mother considerably exceeds the potential risk to the fetus.
Conditions of supply of pharmacies
Without recipe.
side effects
Generally, when the short-term application of sodium picosulfate almost no side effects. Side effects develop during chronic administration of the drug.
From the digestive system: worsening constipation, megacolon. At higher doses – colic, diarrhea, intestinal cramping.
From a metabolism: a violation of water-electrolyte balance, dehydration, hyponatremia.
Cardio-vascular system: lowering blood pressure.
From the nervous system: convulsions.
special instructions
Not recommended for use without medical supervision for more than 10 days. In the application of the sodium picosulfate in high doses and for a long time may appear symptoms water-electrolyte imbalance, including hyponatremia. We can not exclude the possibility of spontaneous bowel movements. If the nature of the chair when taking sodium picosulphate does not change for a long time, you should consult a doctor to determine the cause of constipation.
Picosulphate sodium does not affect the ability to manage trucks and other machinery.
Storage conditions
At temperatures from +15 C to +25 C. Do not freeze!
Keep out of the reach of children.
Dosing and Administration
Inside, diluted in a little water before going to bed.
Adults and children over 10 years: 12-24 drops (5-10 mg).
Children from 4 years to 10 years: 6-12 drops (2.5-5 mg).
Depending on the effect of the dose in the following methods to increase or decrease.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist