L-thyroxine 150 Berlin-Chemie 150mkg tab 100 pcs

$3.63

L-thyroxine 150 Berlin-Chemie 150mkg tab 100 pcs

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Description

Composition
Active substance:
1 tablet contains: L-thyroxine Berlin-Chemie 50: levothyroxine sodium – 0.05 mg.
L-Thyroxine Berlin-Chemie 75: levothyroxine sodium – 0,075 mg.
L-Thyroxine 100 Berlin-Chemie: levothyroxine sodium – 0.10 mg.
L-Thyroxine 125 Berlin-Chemie: levothyroxine sodium – 0,125 mg.
L-Thyroxine 150 Berlin-Chemie: levothyroxine sodium – 0.15 mg.
Excipients:
Calcium hydrogenphosphate 2-water; microcrystalline cellulose; carboxymethylstarch sodium, type A; dextrin: long-chain partial glycerides.
Product form:
Tablets 50,75,100,125 or 150 mg
The blister 25 pcs .; a stack of cardboard 2 or 4 blister.
Contraindications
Individual hypersensitivity to the drug;
Untreated hyperthyroidism;
Acute myocardial infarction, acute myocarditis;
Untreated adrenal insufficiency.
Precautions should be prescribed the drug for diseases of the cardiovascular system: ischemic heart disease (atherosclerosis, angina, myocardial infarction), hypertension, arrhythmia, diabetes, severe long-existing hypothyroidism, malabsorption syndrome (may require dose adjustment).
Indications
hypothyroidism; euthyroid goitre; as replacement therapy and for the prevention of recurrence of goiter after thyroid gland resection; thyroid cancer (after surgery); Graves’ disease: after reaching tireostatikami euthyroid state (as monotherapy or combined); as a diagnostic tool for the test thyroid suppression.
Interaction with other drugs
Levothyroxine increases the effects of anticoagulants, which may require a reduction in their dose.
The use of tricyclic antidepressants with levothyroxine may result in increased antidepressants.
Thyroid hormones may increase the need for insulin and oral hypoglycemic drugs. More frequent monitoring of blood glucose is recommended in periods beginning treatment levothyroxine, and when changing dose.
Levothyroxine reduces the effect of cardiac glycosides. With simultaneous use of cholestyramine, colestipol and aluminum hydroxide reduces the plasma concentration of levothyroxine due to inhibition of its absorption in the intestine.
While the use of anabolic steroids, asparaginase, tamoxifen possible pharmacokinetic interaction at the level of binding to the protein.
In an application with phenytoin, salicylates, clofibrate, furosemide is increased in the high dose content is not bound to plasma proteins and T4 levothyroxine.
Somatotropin while the use of levothyroxine can accelerate the closing of the epiphyseal growth zones.
Receiving phenobarbital, carbamazepine and rifampicin may increase the clearance of levothyroxine and require dose escalation.
Estrogens increase the concentration of the fraction bound to thyroglobulin, which may reduce the effectiveness of the drug.
Amiodarone, aminoglutethimide, p-aminosalicylic acid (PAS), ethionamide, antithyroid drugs, beta-blockers, carbamazepine, chloral hydrate, diazepam, levodopa, dopamine, metoclopramide, lovastatin, somatostatin affect the synthesis, secretion, distribution and metabolism of the drug.
Overdose
If overdose with symptoms typical of hyperthyroidism: palpitations, cardiac arrhythmias, heart pain, anxiety, tremors, insomnia, sweating, increased appetite, weight loss, diarrhea. Depending on the severity of the symptoms your doctor may be recommended to decrease the daily dose, a break in treatment for a few days, the appointment of beta-blockers. After the disappearance of the side effects of treatment should be started cautiously with lower doses.
pharmachologic effect
Pharmacological group:
Thyroid remedy.
Pharmacodynamics:
Synthetic levorotatory isomer of thyroxine. After partial conversion to triiodothyronine (liver and kidney) and return to the body’s cells, affects the development and growth of tissue metabolism. In low doses it has an anabolic effect on protein and fat metabolism. In moderate doses, stimulates growth and development, increases tissue oxygen demand, stimulate the metabolism of proteins, fats and carbohydrates, increases the functional activity of the cardiovascular system and central nervous system.
In high doses, it inhibits the production of thyrotropin-releasing hormone from the hypothalamus and pituitary thyroid stimulating hormone.
The therapeutic effect was observed in 7-12 days, during the same time still apply after discontinuation of the drug. The clinical effect of hypothyroidism is manifested through 3-5 days. Diffuse goiter is reduced or disappears within 3-6 months.
Pharmacokinetics:
When ingestion of levothyroxine is absorbed almost exclusively in the upper small intestine. Absorbed to 80% of the dose preparation. Food intake reduces the absorption of levothyroxine. The maximum serum concentration reached approximately 5-6 hours after ingestion. After absorption of more than 99% of the drug binds to serum proteins (thyroxine-binding globulin, thyroxine-binding prealbumin and albumin). In various tissues occurs monodeyodirovanie levothyroxine about 80% to form a triiodothyronine (T3) and inactive products. Thyroid hormones are metabolized mainly in the liver, kidney, brain and muscle. A small amount of the drug undergoes deamination and decarboxylation as well as conjugation with sulfuric acid and glucuronic acid (in the liver). Metabolites are excreted in urine and bile. The half-life of 6-7 days. Thyrotoxicosis half-life is shortened to 3-4 days, and hypothyroidism is extended to 9-10 days.
Pregnancy and breast-feeding
During pregnancy and breastfeeding levothyroxine therapy, appointed about hypothyroidism, should be continued. During pregnancy, an increase in dosage is required because of higher levels of thyroxine-binding globulin svyazyvayushego. The amount of thyroid hormone, secreted in breast milk during lactation (even during treatment with high doses of the drug), not enough to cause any disorder in the child. Use of the drug in combination with tireostatikami contraindicated in pregnancy because the reception levothyroxine may require increasing doses thyreostatics. Since tireostatiki, unlike levothyroxine, can cross the placenta, the fetus may develop hypothyroidism. During the period of breastfeeding medication should be taken with caution, strictly recommended doses under medical supervision.
Conditions of supply of pharmacies
On prescription.
side effects
When properly used under the supervision of a physician the side effects are not observed.
In case of hypersensitivity to the drug may experience allergic reactions.
special instructions
In hypothyroidism, due to lesions of the pituitary gland, it is necessary to find out whether there is a failure of the adrenal cortex at the same time. In this case, the substitution therapy with glucocorticosteroids should be started before initiating treatment of hypothyroidism with thyroid hormone to prevent the development of acute adrenal insufficiency. The drug has no effect on professional activities related to the driving of vehicles and management mechanisms.
Storage conditions
At a temperature of not higher than 25 C.
Drug store out of reach of children !.
Dosing and Administration
The daily dose is determined individually, depending on indications. L-Thyroxine 50/75/100/125/150 Berlin-Chemie at a daily dose taken orally in the morning on an empty stomach, at least 30 minutes before eating, drinking pill small amount of liquid (glass of water) and not liquid.
When replacement therapy of hypothyroidism patients younger than 55 years in the absence of cardiovascular disease L-Thyroxine 50/75/100/125/150 Berlin-Chemie administered in a daily dose of 1.6-1.8 mg / kg body weight; in patients older than 55 years or with cardiovascular disease – 0.9 g / kg body weight. With a significant obesity calculation should be made on the “ideal weight”.
The initial stage of replacement therapy for hypothyroidism:
Patients without cardiovascular disease under 55 years: initial dose: Women – 75-100 mg / day, men – 100-150 mg / day
Patients with cardiovascular disease or older than 55 years:
Initial dose – 25 micrograms per day
Increase of 25 ug at intervals of 2 months prior to the normalization of blood TSH
When the symptoms or worsening cardiac carry out the correction of cardiac therapy
Treatment euthyroid goiter – 75-200 mg / day.
Prevention of relapse after surgery for euthyroid goitre – 75-200 mg / day.
In the treatment of thyrotoxicosis – 50-100 mg / day
Suppressive therapy of cancer of the thyroid gland – 150-300 mg / day
For accurate dosage of the drug to use the most suitable dosage of the drug L-thyroxine Berlin-Chemie (50, 75, 100, 125 or 150 mcg.)
Infants daily dose of L-Thyroxine 50/75/100/125/150 BH given in a time of 30 minutes before the first feeding. A tablet is dissolved in water until a fine suspension, which is prepared immediately before administration of the drug. In patients with severe long-existing hypothyroidism treatment should be started with caution, with small doses – from 25.0 mg / day, the dose was increased to support over longer intervals – 25.0 mg / day every 2 weeks, and often determine the level of TSH in the blood. In hypothyroidism L-Thyroxine 50/75/100/125/150 BH take usually lifelong. Thyrotoxicosis L-Thyroxine 50/75/100/125/150 BH is used in combination therapy with tireostatikami after the euthyroid state. In all cases, the duration of drug treatment determined by the doctor.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Berlin Chemie

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