Korneregel gel Ch. 5% 5g

Description

Composition
Active substance:
1 g of gel contains: dexpanthenol 50.00 mg.
Excipients:
Cetrimide 0.10 mg disodium edetate 0.10 mg 0.10 mg carbomer, sodium hydroxide 1.01 mg Water for injection 945.79 mg.
Description:
Clear or slightly opalescent, colorless free-flowing gel.
Product form:
Mr. fir eye 5%.
5 g or 10 g of a tube with a head having a nozzle and a screw cap of PVP. 1 tube together with instructions for medical use in a cardboard package.
Contraindications
Individual hypersensitivity to any component of the drug.
Carefully:
During pregnancy and breastfeeding period (clinical data available).
Dosage
5 %
Indications
Treatment of non-inflammatory nature keratopathy, e.g., such as corneal dystrophy, recurrent erosion, corneal contact lens.
As an adjunct therapy to stimulate corneal healing process and conjunctiva during their injuries and burns (chemical and thermal).
Adjunct in the treatment of infectious lesions of bacterial, viral or fungal origin of the cornea.
Interaction with other drugs
Cases of incompatibility with other drugs are unknown.
In those cases where a more local therapy eyedrops / ointments, the interval between administration of drug and Korneregel other ophthalmic preparations shall be at least 15 minutes.
Due to its physical properties, Korneregel drug can extend the residence time of other ophthalmic drugs to the eye and, thus, to strengthen their action. Therefore Korneregel should be applied last.
Overdose
Data on overdose of the drug available.
pharmachologic effect
Pharmacological group:
Tissue repair promoter.
Pharmacodynamics:
The active substance preparation is Korneregel dexpanthenol / panthenol – a precursor of pantothenic acid which thus has all the same biological properties as the D-pantothenic acid, which is transformed in the body into coenzyme A, is involved in many metabolic processes. Data obtained in animal experiments showed an increase of fibroblast proliferation and the presence of the regenerating effect. When applied topically dexpanthenol is able to fill the increased need damaged skin or mucosa of pantothenic acid.
Ophthalmic gel has a high viscosity, which allows for prolonged contact with dexpanthenol mucosal surface of the eye.
Pharmacokinetics:
By studying the results of tritiated dexpanthenol, set its penetration (adsorption) through the skin. To increase contact time with an aqueous solution of dexpanthenol corneal epithelium composed Korneregel preparation contains carbomer, which due to high molecular weight does not penetrate into the eyeball tissue is not absorbed into the systemic circulation.
Pregnancy and breast-feeding
Data on the effects of pantothenic acid ingestion on pregnancy and fetal development or newborn health are absent. However, it is known that the ingestion of pantothenic acid, which metabolizes dexpanthenol, freely crosses the placenta and is outputted through breast milk in proportion to the number of the received formulation.
Since the data on the concentration of dexpanthenol (pantothenic acid) in the blood plasma after topical application in the form of eye gel are not available, use of the drug Korneregel during pregnancy and / or breastfeeding is possible only after consultation with a physician, the expected benefit to the mother outweighs the potential risk to the fetus and / or child.
Conditions of supply of pharmacies
Without recipe.
side effects
Itching, redness, swelling of the conjunctiva, pain, feeling of “foreign body”, increased lacrimation, transient “blurred” vision.
Allergic reactions: seldom – hypersensitivity (itching, skin rash).
special instructions
Korneregel should not be used as monotherapy infectious lesions of bacterial, viral or fungal origin of the cornea. The preservative is cetrimide, part of the drug at long or too frequent use may cause local irritation of the eye, allergic reactions (burning, redness, the feeling of “foreign body” in the eye) and damage to the corneal epithelium.
The period of treatment is not recommended Korneregel wearing contact lenses in view of possible incompatibility of the drug with the lens material. However, if the contact lens is still shown, before use of the drug Korneregel they should be removed and put on again not earlier than 15 minutes after instillation of the drug.
Do not touch the tip of the pipette tube to the eye.
Tube to be closed after each use.
If no improvement is noted state, there are signs of eye irritation, you should stop using the product and consult a physician.
Effects on ability to drive and use complex mechanisms.
After instillation of the preparation a thin film on the cornea, which can cause momentary “fogging” of, thereby reducing the reaction rate. Therefore, the management of vehicles and mechanisms should be initiated when the clarity of vision will be restored.
Storage conditions
In the dark place at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Locally.
In the lower conjunctival sac of the affected eye one drop four times a day, as well as one drop before bedtime.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist