Korilip suppositories neo-Recto. 10 pieces

Description

Composition
Active substance:
1 suppository contains: cocarboxylase hydrochloride – 12.5 mg, riboflavin – 1.0 mg, lipoic acid (thioctic acid) – 6.0 mg ;.
Excipients:
Hard fat (fatty acid glycerides) – 930.5 mg.
Description:
Suppositories yellow, torpedo-shaped with possible patches of orange-yellow color.
Product form:
Rectal suppositories (12.5 mg + 1 mg plus 6 mg). 5 suppositories in blisters made of PVC film. Two contour package together with instructions for use in paper cartons.
Contraindications
hypersensitivity reaction to the components included in the preparation.
Inflammation or bleeding in the rectum (contraindications associated with the administration through).
Dosage
12.5 mg + 1 mg plus 6 mg
Indications
The drug is indicated for use as a prophylactic and therapeutic purposes in the treatment for correcting the energy deficient states, increasing efficiency of the basic treatment and accelerating the recovery processes in various pathological conditions in children such as: • chronic tissue hypoxia syndrome (respiratory disorders, central nervous system hypoxic damage and et al.). • Reduced immunity (protracted and recurrent course of SARS, sickly children, the stress state of the body, including in the carrying out of preventive vaccination during epidemics of infectious). • Bacterial and viral infections during the period of repair (recovery), including acute intestinal infections due to viral and bacterial agents (rotavirus gastroenteritis, Calicivirus infection et al.), And complications of acute intestinal infections (exsicosis, toxemia, dysbacteriosis and others.). • chronic somatic diseases (congenital heart disease, pneumonia, bronchitis, chronic inflammatory diseases of the urinary system, dyskinesia, gastrointestinal tract, allergic reactions, hyperexcitability syndrome, asthenic states, and others.). • Chronic intoxication. • Eating disorders (malnutrition) in children.
Interaction with other drugs
Adverse interactions have been noted. The drug can be used in complex therapy.
Overdose
Overdose cases are not described.
pharmachologic effect
Pharmacodynamics:
Combination drug action is determined by the effects of its constituent vitamins and coenzymes, their synergistic effect. Preparation improves tissue metabolism in a variety of physiological and pathological conditions requiring correction cofactors and substrates.
kokarboksilaza
Cocarboxylase – coenzyme thiamine (vitamin B1), in an organism is phosphorylated to form the mono-, di-, triphosphate ester, part of the enzymes that catalyze carboxylation and decarboxylation of alpha-keto acid, pyruvic acid. Endogenous kokarboksilaza formed in the body from exogenous phosphorylation of thiamine, cocarboxylase properties but does not completely correspond thiamine properties and can not be used for the prevention and treatment of hypo-and vitamin B1. Cocarboxylase improves glucose uptake, tissue trophism nervous system, promotes the normalization of the cardiovascular system. Lowers lactic and pyruvic acid in the blood (elevated levels of these acids leads to the development of acidosis and acidotic coma).
Riboflavin
Riboflavin (vitamin B2) has metabolic effects; is reacted with ATP to form coenzymes flavinproteinov -. flavinadeninmononukleotid and flavin adenine dinucleotide, which are components of enzymes such as succinate dehydrogenase, tsitohromreduktazy, diaphorase, amino acid oxidase, etc. By adjusting the oxidation-reduction processes taking part in the transfer of hydrogen (H +), tissue respiration, carbohydrate, protein and fat metabolism, in the maintenance of normal visual function of the eye, the synthesis of hemoglobin, and erythropoietin.
Activated riboflavin piridoksalkinaza turns pyridoxine (vitamin B6) to its active form pyridoxal phosphate. It promotes the conversion of tryptophane into niacin, preservation of erythrocyte integrity. Included in the glutathione reductase, xanthine oxidase. Synthesized by the normal intestinal microflora and he needs to maintain it.
thioctic acid
Thioctic acid (alpha-lipoic acid) – endogenous antioxidant (binds free radicals). The body is formed by oxidative decarboxylation of alpha-keto acids. As coenzyme mitochondrial multienzyme complexes involved in the oxidative decarboxylation of pyruvic acid and alpha-keto acids. By the nature of the biochemical action of thioctic acid is close to vitamins of group B improves neuronal trophism. Thereby reducing blood glucose and increased glycogen content in the liver, and reduce insulin resistance. Participates in the regulation of lipid and carbohydrate metabolism, stimulates cholesterol metabolism, improves liver function has a detoxication effect for poisoning by heavy metal salts and other intoxications. It has gepatoprotektoronoe, lipid-lowering, cholesterol-lowering, hypoglycemic effect.
Pharmacokinetics:
kokarboksilaza
Kokarboksilaza penetrates into most body tissues, but the highest concentration in the liver, kidneys, brain and heart. It is metabolized in the liver. metabolites excreted primarily by the kidneys.
Riboflavin
Riboflavin is unevenly distributed (the largest quantity in the myocardium, liver, kidneys). Communication (mainly as metabolites – flavinadeninmononukleotida and flavin adenine dinucleotide) to plasma proteins – 60%. It crosses the placenta and breast milk. It is metabolized in the liver. Excreted by the kidneys, mainly as metabolites. The half – 66-84 min.
thioctic acid
Thioctic acid is metabolized in the liver by the oxidation of side chain conjugation. The volume of distribution – about 450 ml / kg. Total plasma clearance – 10-15 ml / min. Thioctic acid and its metabolites are excreted by the kidneys (80-90%). The half – 20-50 min.
Conditions of supply of pharmacies
By prescription.
side effects
Allergic reactions – urticaria, pruritus, bronchospasm, dyspepsia.
When the side effects stop using the product and seek medical advice.
special instructions
The criteria for the duration of the treatment together with the clinical condition indicators are cytochemical enzyme activity of peripheral blood leukocytes (succinate dehydrogenase and glitserofosfatdegidroginaza).
Storage conditions
In the dark place at a temperature not higher than 20 ° C. Keep out of the reach of children.
Dosing and Administration
The drug is used rectally. Freed from the packaging, enter the suppository into the anus after a bowel movement prior.
Suppositories are administered to children up to 1 year 1 suppository per day.
Duration of treatment – 10 days. The total duration of treatment – 3-4 courses with an interval of 20 days (3 – 4 months).
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist