Kordinik tab 10mg 60 pc


Kordinik tab 10mg 60 pc



Active substance:
1 tablet contains: nicorandil 10mg or 20mg.
Potato starch, microcrystalline cellulose, calcium stearate.
Tablets with poor white grayish-yellowish white color, circular shape, Valium, with a chamfer.
Product form:
Tablets of 10 mg and 20 mg. 10 tablets in blisters. 2, 3 or 6, the contour of cellular packaging together with instructions for use placed in a pile of cardboard.
Hypersensitivity to the drug; acute myocardial infarction (and within 3 months after); cardiogenic shock, collapse; unstable angina; chronic heart failure III or IV functional class NYHA classification; bradycardia (heart rate less than 50 beats / min.); atrioventricular block II and III degree; left ventricular failure with low pressure filling; hypotension (systolic blood pressure less than 100 mm Hg..); simultaneous reception of phosphodiesterase-5 inhibitors (sildenafil, vardenafil, tadalafil); pregnancy and breastfeeding (see “Application of pregnancy and during lactation.”); age 18 years (effectiveness and safety have been established).
Precautions: cardiac arrhythmias, atrioventricular block I degree, Prinzmetal angina, hypotension, renal dysfunction and / or liver, hypovolemia, pulmonary edema, angle-closure glaucoma, hyperkalemia, anemia.
10 mg
Relief of angina; prevention of stable angina attacks (in combination with 3 other antianginal drugs) and as monotherapy intolerance beta-blockers and BCCI.
Interaction with other drugs
If simultaneous reception with antidepressants, inhibitors of phosphodiesterase-5 (sildenafil, vardenafil, tadalafil), vasodilators, antihypertensive agents, tricyclic antidepressants, diuretics, beta-blockers, inhibitors of monoamine oxidase (MAO) and ethanol – increased anti-anginal action. At the same time taking the drug, the drug sapropterin possibly lowering blood pressure below normal.
Symptoms: marked reduction of blood pressure, tachycardia.
Treatment: gastric lavage, appointment of activated carbon (especially in the first 2 hours after the overdose), maintaining the function of the cardiovascular system, limb elevated position, symptomatic and supportive therapy, in / to the introduction of calcium gluconate and dopamine. Perhaps the use of hemodialysis.
pharmachologic effect
Pharmacological group:
Antianginal agent – a potassium channel activator.
Nicorandil has antianginal effect, which is based on a combination nitratopodobnyh properties and ability to open potassium channels. Due to the opening of potassium channels nicorandil causes hyperpolarization of the cell membrane, and nitratopodobny effect is an increase in intracellular cyclic guanilmonofosfata 2. These pharmacological effects lead to relaxation of smooth muscle cells and cell protecting myocardium during ischemia. Hemodynamic Effects are expressed in a balanced decrease pre- and afterload (unlike blockers and nitrates “slow” calcium channel (BCCI), which act mainly on pre- and afterload, respectively). Given the selective vasodilation of coronary arteries as a result of the load on the ischemic myocardium is minimal. Nicorandil has no effect on myocardial contractility, practically no effect on heart rate (HR). Reduces systemic blood pressure (BP) is less than 10%, has a beneficial positive effect on cerebral blood flow in patients with ischemic stroke. Nicorandil has no effect on lipid metabolism and glucose metabolism. Nicorandil relieves angina with a decrease in pain for 4-7 minutes once under the tongue and complete relief within 12-17 minutes.
Nicorandil is rapidly and completely absorbed from the gastrointestinal tract, reaching maximum plasma concentrations over 0.5-1 hour. Unaffected extensively metabolized in the liver and has a half-life of 50 min. Write mainly kidneys. Nicorandil significantly bind to plasma proteins. Free fraction in plasma is about 75%. Pharmacokinetic parameters do not greatly depend on the age of the patient, presence of concomitant diseases of liver or kidneys, destination concomitant therapy.
Pregnancy and breast-feeding
It is not recommended to use the drug during pregnancy and breastfeeding period due to lack of clinical experience in these patients.
Conditions of supply of pharmacies
side effects
Cardiovascular system: palpitations, tachycardia, decreased blood pressure, “tides” of blood to the skin, peripheral edema.
Central Nervous System: weakness, headache (not require discontinuation of therapy, can be alleviated by reducing the initial dose), vertigo, tinnitus, and insomnia.
Digestive tract: nausea, vomiting, discomfort in the stomach, feeling of fullness in the stomach, stomatitis (very rare); in some cases may increase the activity of “hepatic” transaminases (ALT and AST), alkaline phosphatase.
Hypersensitivity reactions: possible allergic reactions.
special instructions
The drug should be withdrawn gradually. During therapy with need to control blood pressure, ECG, the content of potassium ions and sodium ions in the blood; may increase existing cardiac arrhythmias.
Effects on ability to drive vehicles, mechanisms need to be cautious when driving and busy with other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
In a dry, dark place at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Inside. Drinking water, taken irrespective of food intake. Prevention of stable angina attacks (chronic treatment of stable angina). The drug is usually administered in a dose of from 10 to 20 mg of 2 – 3 times a day. The recommended starting dose of 10 mg 2 times a day. The effective therapeutic dose of the drug is chosen individually depending on the severity and duration of the disease. The maximum daily dose of 80 mg. When headache initial dose can be reduced. Relief of angina. The drug should be taken immediately upon the first sign of angina: the drug at a dose of 20 mg is placed under the tongue and held until complete dissolution, without swallowing.
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg


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