Kondronova caps. 30 pc

Description

Composition
Active substance:
1 capsule contains: 250 mg of glucosamine sulfate, chondroitin sulfate 200 mg.
Excipients:
Mannitol 60.0 mg croscarmellose sodium 20.00 mg magnesium stearate 5.0 mg talc 5.0 mg of the purified
Capsule shell: Purified water 13.536 mg 81.024 mg of gelatin, sodium lauryl sulfate 0.096 mg, 0.096 mg of povidone, 0.096 mg bronopol, colorant titanium dioxide 1.056 mg, Brilliant Blue dye 0.08832 mg, quinoline yellow dye 0.00768 mg.
Description:
Hard gelatin capsule size light blue color “0”, containing white or almost white powder.
Product form:
Capsules, 250 mg + 200 mg
10 capsules in blisters made of PVC / Al.
3 or 12 blisters together with instructions for medical use in a cardboard box.
Contraindications
KONDROnova® drug is contraindicated in: patients with a known hypersensitivity to the ingredients of this drug; pregnant and lactating women; children.
CAREFULLY
Diabetes, asthma, bleeding tendency, thrombophlebitis.
Dosage
250 mg + 200 mg
Indications
Osteoarthritis of peripheral joints and spine joints.
Interaction with other drugs
Possible potentiation of anticoagulants and antiplatelet agents.
KONDROnova® increases the absorption of tetracycline, reduces the effect of semisynthetic penicillins. The product is compatible with glucocorticoid drugs.
Overdose
Cases of overdose KONDROnova® unknown. In the event of overdose recommended gastric lavage and symptomatic therapy.
Extremely high doses of glucosamine (many times the recommended daily dose) may cause diarrhea or nausea, the occurrence of hemorrhagic lesions.
pharmachologic effect
Pharmacological group:
Stimulator of tissue repair.
Pharmacological properties:
Glucosamine sulfate and chondroitin sulfate are involved in the biosynthesis of connective tissue and thereby can help to prevent cartilage destruction processes and stimulate tissue regeneration.
Pharmacodynamics:
glucosamine sulphate
Glucosamine sulfate is one component of synthesis of hyaluronic acid, which is required to form the structural matrix proteoglycans joints.
It was also found that glucosamine sulphate articular cartilage protects against the damaging action of certain non-steroidal anti-inflammatory drugs (NSAIDs). The sulfate ion is essential for the synthesis of glycosaminoglycans, that are esters of sulfuric acid. Ingestion of exogenous glucosamine stimulates the production of cartilage matrix and provides its non-specific protection.
Glucosamine has some antiinflammatory action.
chondroitin sulfate
Chondroitin sulfate, regardless of whether it is absorbed in an intact form or in the form of short fragments, serves as an additional substrate for the formation of healthy cartilage matrix. Chondroitin sulfate (and derivatives thereof) promotes the formation of proteoglycans and type II collagen, and the matrix also protects the cartilage from enzymatic cleavage (by inhibition of hyaluronidase activity) and from the damaging effects of free radicals. Chondroitin sulfate maintains the viscosity of synovial fluid, stimulates cartilage repair mechanisms.
Hoidroitina sulfate in the treatment of osteoarthritis alleviates the symptoms of the disease and reduces the need for NSAIDs.
Pharmacokinetics:
glucosamine
Absorption
In humans, glucosamine oral bioavailability is 25%.
Distribution
After absorption of the oral dose radiolabeled glucosamine initially detected in the plasma components, and later into the tissue. The highest concentrations were found in liver, kidney and the articular cartilage. About 30% of the dose long persist in the bone tissue and muscles.
Elimination
Glucosamine fraction that is not metabolized or is not bound to plasma proteins, mostly excreted in the urine. Most of drug detectable in the feces after oral administration is a non-absorbed fraction. Terminal half-life of the drug bound to plasma proteins, is 68 hours.
chondroitin sulfate
Absorption
When administered chondroitin sulfate once in a dose of 0.8 g of (or twice daily at a dose of 0.4), the concentration of chondroitin sulfate increases sharply in the plasma over 24 hours. The absolute bioavailability is 12%.
Metabolism
Chondroitin sulfate is metabolized by desulfurization (after introduction of low molecular weight chondroitin sulfate).
Elimination
Chondroitin sulfate urine output. The half-life of 310 minutes.
Conditions of supply of pharmacies
Without a prescription.
side effects
The most common side effects include mild gastrointestinal disorders (epigastric pain, bloating, diarrhea, constipation), dizziness, allergic skin reactions, headache, leg pain and peripheral edema, lethargy, insomnia and tachycardia.
Allergic reactions, exacerbation of asthma.
special instructions
Intolerance to seafood likelihood of allergic reactions increases.
Storage conditions
Store in a dry, dark place at a temperature not higher than 30 ° C.
Keep out of the reach of children.
Dosing and Administration
Orally. Adults 2 capsules 2-3 times a day. After 60 days of therapy, the dose should be reduced gradually, depending on the needs of the individual patient.
Course of treatment: 2-3 months (the duration of treatment is determined by the doctor). Re-treatment is possible only after consultation with your doctor.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist