Koldreks hotra powder for solution into 10 pieces 5g menthol and honey lemon

$7.89

Koldreks hotra powder for solution into 10 pieces 5g menthol and honey lemon

Quantity:

Description

Composition
Active substance:
paracetamol 600 mg, phenylephrine hydrochloride, 10 mg, 40 mg ascorbic acid.
Excipients:
sodium saccharinate 10 mg; 50 mg aspartame; Sucrose 3755 mg; Sodium citrate 500 mg; Citric acid anhydrous 400 mg; corn starch 200 mg; menthol powder E41580 150 mg; lemon flavor PHS – 163 671 75 mg; honey flavor PHS-050860 50 mg; honey flavor F7624P 100 mg; caramel colorant 626E150A 60 mg.
Description:
Bulk heterogeneous powder from nearly white to light brown with honey odor, lemon and menthol. The powder may have blotches of darker color.
The prepared solution:
The cloudy solution was brownish-orange color, without having surface foam with a strong smell of honey, lemon and menthol. The solution may contain a slight amount of precipitate.
Product form:
10 bags together with instructions for use in a cardboard package.
Contraindications
The drug Coldrex Hawtrey Menthol and lemon honey is not recommended for patients with:
hypersensitivity to paracetamol, phenylephrine, ascorbic acid (vitamin C) or any other component of the formulation;
human liver function and kidney severe;
hypertension;
hyperthyroidism (including thyrotoxicosis);
heart diseases (when expressed aortic stenosis, acute myocardial infarction, tachyarrhythmia);
prostatic hyperplasia;
diabetes and diseases related to the inherited disorder of sugar intake;
genetic absence of glucose 6-phosphate dehydrogenase;
deficiency sucrase / isomaltase, fructose intolerance, glucose-galactose malabsorption, since of the drug includes sucrose;
angle-closure glaucoma;
phenyl ketonuria, since preparation comprises aspartame;
simultaneous administration of tricyclic antidepressants, beta-blockers and other antihypertensive drugs, MAO inhibitors, including up to 14 days after their withdrawal;
simultaneous reception of other paratsetamolsoderzhaschih medicines, decongestants, non-narcotic analgesics, non-steroidal anti-inflammatory drugs, drugs for the relief of symptoms “cold” flu and nasal congestion, drugs that regulate appetite, amfetaminpodobnyh stimulants, barbiturates, antiepileptic drugs, rifampicin, chloramphenicol (see. section “The interaction with other drugs”);
simultaneous reception etanolsoderzhaschih beverages and pharmaceuticals;
alcoholism;
Children under 12 years old.
Carefully
If you have one of these diseases / conditions / risk factors before taking this medication, you should consult with your doctor:
Benign hyperbilirubinemia.
Human liver and kidney mild to moderate severity.
Alcoholic liver disease.
Stenosing peptic ulcer and / or duodenal ulcers.
prostate disease and urinary problems.
Cardiovascular diseases, including hypertension, obliterative vascular disease (Raynaud’s phenomenon).
Glaucoma (excluding closure glaucoma).
Pheochromocytoma.
The presence of severe infections, including sepsis, because the drug may increase the risk of metabolic acidosis.
Patients with glutathione deficiency (in particular, extremely malnourished patients suffering from anorexia, alcoholism, or patients with low body mass index).
Pregnancy and breast-feeding.
Dosage
600 mg + 10 mg + 40 mg
Indications
The drug Coldrex Hawtrey Menthol and lemon honey is used in adults (including the elderly) and children over 12 years as a means to eliminate the symptoms of “cold” and the flu, including:
fever;
headache;
chills;
pain in joints and muscles;
pain in the sinuses and nasal congestion;
a sore throat.
Interaction with other drugs
Paracetamol at reception for a long time increases the effect of anticoagulants (warfarin and other coumarin), which increases the risk of bleeding. Episodic receiving a single dose of the drug has no significant effect on the action of anticoagulants.
Inductors microsomal oxidation enzymes in the liver (barbiturates, phenytoin, carbamazepine, rifampicin, AZT, phenytoin, ethanol, flumetsinol, phenylbutazone and tricyclic antidepressants) increase the risk of hepatotoxicity with overdoses and concomitantly with paracetamol.
Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxicity.
Halothane increases the risk of ventricular arrhythmias.
Paracetamol reduces the effectiveness of diuretic drugs.
Metoclopramide and domperidone to increase, and cholestyramine reduces the rate of absorption of paracetamol.
Paracetamol MAO inhibitors enhances effects, sedation, ethanol.
Simultaneous treatment with paracetamol and alcoholic beverages increases the risk of liver injury and acute pancreatitis.
Phenylephrine when taken with MAO inhibitors may lead to increased blood pressure.
Phenylephrine reduces the effectiveness of beta-blockers and other antihypertensive drugs (including debrizohin, guanethidine, reserpine, methyldopa), increases the risk of hypertension and disorders of the cardiovascular system.
Tricyclic antidepressants increase the sympathomimetic effects of phenylephrine may increase the risk of side effects of the cardiovascular system, the simultaneous use of halothane with phenylephrine increased the risk of ventricular arrhythmias. Phenylephrine reduces guanetidina hypotensive effect, which in turn enhances the activity of alpha-adrenostimuliruyuschee phenylephrine.
Simultaneous treatment with the drug, and ergot alkaloids (ergotamine and methysergide) increases the risk of ergotism.
Antidepressants, antiparkinsonian agents, antipsychotics, phenothiazine derivatives increase the risk of urinary retention, dry mouth, constipation.
Concomitant use of corticosteroids with phenylephrine increases the risk of developing glaucoma.
Concomitant use of digoxin and other cardiac glycosides increase the risk of cardiac arrhythmia and heart attack.
Concomitant use of phenylephrine with sympathomimetic amines can increase the risk of side effects of the cardiovascular system.
Ascorbic acid increases the risk of crystalluria salicylates in the treatment of sulfonamides and short-acting, slow excretion by the kidneys acids, increases the excretion of drugs having an alkaline reaction (including alkaloids), reduces blood levels of oral contraceptives.
Ethanol contributes to the development of acute pancreatitis.
Myelotoxicity drugs increase the expression gematotoksichnosti drug.
Overdose
The drug should only be taken in recommended doses!
If you suspect an overdose, even in good health, you must stop using the product and consult a doctor immediately, because there is a risk of delayed serious liver damage and may require hospitalization.
Overdose is caused, usually paracetamol.
Symptoms (caused by paracetamol)
When paracetamol overdose may develop liver failure, which may require a liver transplant or death.
Within 24 hours, possibly: pallor of skin, loss of appetite, nausea, vomiting, stomach pain, sweating. Within 12-48 hours may manifest signs of liver dysfunction (increased activity “liver” transaminases, prolonged prothrombin time, gepatonekroz). May show signs of impaired glucose metabolism and metabolic acidosis. Toxic effects in adults is possible after taking over 10 g of paracetamol. The clinical picture of liver damage appears after 1-6 days. In case of severe poisoning can develop severe liver failure until liver encephalopathy, liver transplant needed, coma and death may occur in addition hemorrhage, hypoglycemia, brain edema. Acute renal failure with acute tubular necrosis, which is diagnosed by severe pain in the lumbar region, hematuria and proteinuria, may develop without severe hepatic dysfunction. There are reports of cardiac arrhythmias and pancreatitis with an overdose of paracetamol.
Receiving 5 grams or more of acetaminophen can cause liver damage in patients who have the following risk factors:
prolonged treatment with carbamazepine, phenobarbital, phenytoin, primidone, rifampicin, Hypericum perforatum drugs, or other drugs that stimulate liver enzymes;
regular consumption of alcohol in excessive amounts;
glutathione deficiency (due to eating disorders, cystic fibrosis, HIV infection, starvation, exhaustion).
At the first sign of overdose should seek emergency medical attention even in the absence of distinct symptoms of poisoning. In the early period of symptoms may be limited to nausea or vomiting and may not reflect the degree of the severity of overdose or the degree of internal organ damage risk.
Treatment: during the first hour after the intended purpose it is expedient to overdose activated charcoal inside. After four hours or more after the intended overdosing is necessary to determine the concentration of paracetamol in plasma (earlier definition paracetamol concentrations may be misleading). acetylcysteine ​​treatment may be up to 24 hours after ingestion of paracetamol, however, the maximum hepatoprotective effect can be obtained for the first 8 hours after the overdose. After that, the effectiveness of antidote drops sharply. If necessary acetylcysteine ​​can be administered intravenously. In the absence of emesis alternative embodiment (without the possibility of quick inpatient care) is the designation methionine inside. Treatment of patients with serious hepatic dysfunction at 24 hours after ingestion of paracetamol should be carried out together with specialists or poison control center specialized branch of liver diseases.
Symptoms (due phenylephrine)
Symptoms of overdose of phenylephrine are similar to the side effects. In addition: high blood pressure, reflex bradycardia. In severe cases an overdose may develop hallucinations, confusion, seizures, arrhythmias. Note that the appearance of clinically significant symptoms of phenylephrine overdose while taking the drug is always associated with severe liver disease on the background of paracetamol overdose.
Treatment: symptomatic therapy, with severe hypertension use of alpha-blockers such as phentolamine.
Symptoms (due to ascorbic acid)
In the application of 1,000 mg or more of ascorbic acid can appear headache, increased excitability of the central nervous system, insomnia, nausea, vomiting, diarrhea, hyperacid gastritis, damage to the gastrointestinal mucosa, inhibition insular pancreatic apparatus function (hyperglycemia, glycosuria), hyperoxaluria, nephrolithiasis (calcium oxalate), renal glomerular damage the apparatus, decrease capillary permeability (possible deterioration of tissue trophism, increased blood pressure, hypercoagulation, development of microangiopathy).
High doses of ascorbic acid (3000 mg) can cause osmotic diarrhea, and the temporary disruption of the gastrointestinal tract, such as nausea, discomfort in the stomach area. It will be appreciated that the occurrence of clinically significant symptoms of ascorbic acid while taking the drug overdose always associated with severe liver amid paracetamol overdose.
Treatment: symptomatic, forced diuresis.
pharmachologic effect
Pharmacological group:
ARI and “cold” symptoms Remedy (non-narcotic analgesic agent + alpha-agonists plus vitamin).
Pharmacodynamics:
Combined means whose action is due to its constituent components.
Paracetamol is an analgesic and antipyretic. Its mechanism of action is presumed the suppression of prostaglandin synthesis, preferably in the central nervous system. It does not affect the function of platelets and hemostasis.
Paracetamol has almost no effect on the synthesis of prostaglandins in peripheral tissues, it does not change the water-electrolyte metabolism and does not damage the mucosa of the gastrointestinal tract.
Phenylephrine hydrochloride – sympathomimetic agent, whose action is directed to stimulation of adrenergic receptors (mainly alpha-adrenoceptor), which leads to a reduction in edema of the nasal mucosa and nasal congestion relief.
Ascorbic acid (vitamin C) compensates for the increased need for vitamin C at a “cold” and flu, especially in the early stages of the disease.
Included in the components of the drug does not cause drowsiness and can impair concentration.
Pharmacokinetics:
Paracetamol: Paracetamol absorption from the gastrointestinal tract – high. The time to reach maximum plasma concentration – 0.5 – 2 chasa; maximum plasma concentration – 5-20 .mu.g / ml. Communication with plasma proteins – 15%. It penetrates the blood-brain barrier.
Phenylephrine hydrochloride uniformly absorbed in the gastrointestinal tract. Maximum plasma concentration is achieved in the range of from 45 minutes to 2 hours.
Ascorbic acid is rapidly absorbed from the gastrointestinal tract and distributed throughout the body. Communication with plasma proteins is 25%.
Metabolism
Paracetamol is metabolized primarily in the liver (90 – 95%) in three main ways: 80% enters into the conjugation reaction with glucuronic acid and sulphates to inactive metabolites; 17% undergo hydroxylation to form 8 active metabolites, which is conjugated with glutathione to form already inactive metabolites. With a lack of glutathione, these metabolites may block the enzyme systems of hepatocytes and cause their death. The metabolism of the drug is also involved isoenzyme CYP2E1.
Phenylephrine hydrochloride undergoes primary monoamine oxidase metabolism in the intestine and liver. Thus, for oral administration of phenylephrine bioavailability decreases.
breeding
Paracetamol kidneys displayed as metabolites, mainly glucuronide and sulfate conjugates of about 3% is released in unaltered form. The half-life of 1 -4 hours. In elderly patients, reduced clearance of the drug and increases the half-life, however, the drug dose adjustment is required.
Phenylephrine hydrochloride almost completely excreted by the kidneys in the form of sulfate conjugates. excretion period is 2-3 hours.
When used in doses exceeding the body’s need for ascorbic acid, ascorbic acid excreted by the kidneys in the form of metabolites.
Pregnancy and breast-feeding
Pregnancy
The drug should not be used during pregnancy without first consulting your doctor!
In studies conducted in animals and humans, did not reveal any risk of the use of paracetamol during pregnancy or negative impact on the intrauterine development of the fetus.
Sufficient data on the effect of drugs containing phenylephrine, on pregnancy are not available.
Breastfeeding
The drug should not be used during breast-feeding without first consulting your doctor!
Paracetamol crosses the placental barrier and into breast milk. In studies conducted on humans, there was no evidence of any negative effects on the baby during breastfeeding.
Phenylephrine can pass into breast milk.
Conditions of supply of pharmacies
Without a prescription.
side effects
The recommended dosage is generally well tolerated drug.
The following adverse reactions identified spontaneously during post-marketing the drug.
Adverse reactions are classified by body system and in accordance with the frequency of development. The frequency of adverse reactions is determined as follows: very often (> 1/10), often (> 1/100 and
special instructions
Sufficient data on the effect of the drug on fertility are not available.
If you are taking the drug improved condition is not observed, it is necessary to consult a doctor.
The drug should not be taken simultaneously with other paratsetamolsoderzhaschimi preparations, as well as other non-narcotic analgesics, NSAIDs (metamizole sodium, acetylsalicylic acid, ibuprofen, etc.), drugs for relief of symptoms “cold” and influenza, sympathomimetics (decongestants, drugs that regulate appetite , psychostimulants amfetaminpodobnye), barbiturates, antiepileptic drugs, rifampicin, chloramphenicol.
To avoid liver toxicity drug should not be combined with ethanol-containing drugs and drink, and to take people who are prone to chronic alcohol consumption.
Concomitant liver diseases increase the risk of further damage to the liver while taking the drug. While taking the drug in patients with nonalcoholic cirrhosis there is a high risk of overdose.
When carrying out tests for determination of uric acid and glucose levels in the blood inform the doctor on the application of the drug Koldreks hotra Menthol and lemon honey, since the drug may distort the results of laboratory tests that measure the concentration of glucose and uric acid.
Patients with glutathione deficiency due to eating disorders, cystic fibrosis, HIV infection, starvation, exhaustion, subject to an overdose, so it is necessary to take precautions and before taking this medication are advised to consult with a physician. Cases of hepatic insufficiency development / liver dysfunction with a small overdose of paracetamol (5 g, and more) in patients with low levels of glutathione, particularly in extremely malnourished patients suffering from anorexia, alcoholism, or patients with low body mass index.
Use of the drug by patients with low levels of glutathione, e.g., in sepsis, may increase the risk of metabolic acidosis symptoms accompanied by tachycardia, dyspnea (feeling of breathlessness, dyspnea), nausea, vomiting, loss of appetite. With the simultaneous manifestation of these symptoms should seek immediate medical attention.
Patients suffering from phenylketonuria, the drug is not recommended because it contains aspartame, a source of phenylalanine.
Before taking this medication Coldrex Hawtrey Menthol and lemon honey should consult with your doctor if you are taking:
warfarin or other oral anticoagulants to thin the blood;
metoclopramide, domperidone (used to eliminate nausea and vomiting) or colestyramine used to lower blood cholesterol levels;
if necessary compliance giponatrievoy diet.
The effect on the ability to operate vehicles, machinery
The drug may cause dizziness. При появлении головокружения не рекомендуется управлять транспортными средствами или работать с механизмами
Storage conditions
Хранить при температуре не выше 30 градусов
Keep out of the reach of children.
Dosing and Administration
For ingestion.
Do not exceed this dose!
Should apply the lowest dose necessary to achieve the effect!
Минимальный интервал между приемами препарата Колдрекс ХотРем Ментол и медовый лимон должен составлять не менее 4 ч.
Содержимое 1 пакетика высыпать в кружку, налить половину кружки очень горячей воды и тщательно перемешать. Добавьте холодной воды, если необходимо.
Взрослые (включая пожилых) и дети старше 12 лет: Внутрь, разовая доза – 1 пакетик. Повторное применение препарата возможно не ранее, чем через 4-6 часов и не более 4 раз/сут. The maximum daily dose should not exceed 4 sachets. Максимальная длительность применения препарата без консультации с врачом не более 5 дней. Не рекомендуется принимать препарат в качестве жаропонижающего средства более 3 дней без консультации врача.
Не принимать одновременно с другими парацетамолсодержащими средствами, деконгестантами и средствами для облегчения симптомов «простуды» и гриппа, а также с этанолсодержащими средствами и напитками.
Если при приеме препарата симптомы заболевания сохраняются, необходимо обратиться к врачу.
При превышении рекомендованной дозы препарата незамедлительно обратитесь за медицинской помощью, даже если Вы чувствуете себя хорошо. Передозировка парацетамола может вызвать печеночную и почечную недостаточность.
Special patient groups
Patients with impaired renal function:
Перед применением препарата Колдрекс ХотРем Ментол и медовый лимон пациентам с нарушением функции почек необходимо предварительно проконсультироваться с врачом. Ограничения, связанные с применением препаратов, содержащих такую комбинацию действующих веществ, у пациентов с нарушением функции почек, преимущественно связаны с содержанием парацетамола в лекарственном препарате.
Patients with hepatic impairment:
Перед применением препарата Колдрекс ХотРем Ментол и медовый лимон пациентам с нарушением функции печени необходимо предварительно проконсультироваться с врачом. Ограничения, связанные с применением препаратов, содержащих данную комбинацию действующих веществ, у пациентов с нарушением функции печени, преимущественно связаны с содержанием парацетамола в лекарственном препарате.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

GlaxoSmithKline Helsker

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