Koldreks hotra powder for r-ra 5 pieces lemon

$4.14

Koldreks hotra powder for r-ra 5 pieces lemon

Quantity:

Description

Composition
Active substance:
1 sachet contains: 750 mg of paracetamol,
Phenylephrine Hydrochloride 10 mg
ascorbic acid 60 mg.
Excipients:
Citric Acid – 600 mg Sodium saccharin – 40 mg Sodium Citrate – 500 mg, lemon tetrarom 100% P05.51 – 50 mg, lemon flavor 52293 / TP.05.51 – 83.33 mg, 14031 quinoline yellow (E104) – 0.75 mg sucrose – 2904.42 mg.
Description:
powder for solution for oral administration (lemon) a crystalline, pale yellow to yellow color with a characteristic smell of lemon; prepared solution – yellow in color, with a characteristic lemon smell.
Product form:
5 g of powder in sachets made of laminate (BPFP). 5 sachets together with instructions for use in a cardboard package.
Contraindications
– expressed human liver; – pronounced renal dysfunction; – hyperthyroidism (including hyperthyroidism), – diabetes, – deficit sucrase / isomaltase, fructose intolerance, malabsorption syndrome glucose / galactose as formulation comprises sucrose; – heart disease (expressed aortic stenosis, acute myocardial infarction, tachyarrhythmia), – hypertension, – simultaneous reception of tricyclic antidepressants, beta-blockers, MAO inhibitors and up to 14 days after their withdrawal; – simultaneous reception of other paratsetamolsoderzhaschih funds and to facilitate the symptoms of colds, flu, nasal congestion; – benign prostatic hyperplasia; – closure glaucoma; – children under 12 years of age; – increased feelings telnost to the drug.
Indications
In order to eliminate the symptoms of acute respiratory infections and flu, including: -. Increased body temperature; – headache – chills – pain in joints and muscles – nasal congestion – sore throat and sinuses.
Interaction with other drugs
Paracetamol at reception for a long time increases the effect of anticoagulants (warfarin and other coumarin), which increases the risk of bleeding. Episodic receiving a single dose of the drug has no significant influence on the effect of indirect antikoagulyantov.Induktory microsomal oxidation enzymes in the liver (barbiturates, phenytoin, carbamazepine, rifampicin, AZT, phenytoin, ethanol, flumetsinol, phenylbutazone and tricyclic antidepressants) increase the risk of hepatotoxicity with overdoses and simultaneous reception with paratsetamolom.Ingibitory microsomal oxidation (cimetidine) reduce the risk of hepatotoxicity deystviya.Paratsetamol reduces efficiency Diouri ble preparatov.Metoklopramid and domperidone is increased, and reduces the rate of absorption colestyramine paratsetamola.Paratsetamol MAO inhibitors enhances effects, sedation, etanola.Fenilefrin when taken with MAO inhibitors may increase AD.Fenilefrin reduces the effectiveness of beta-adrenergic blockers and antihypertensive drugs, increases the risk of hypertension and disorders of the cardiovascular sistemy.Odnovremennoe use of phenylephrine with sympathomimetic amines and can increase the risk of side effects from cardiovascular sistemy.Tritsiklicheskie antidepressants increase the sympathomimetic effects of phenylephrine may increase the risk of side effects from cardiovascular sistemy.Odnovremennoe use of halothane with phenylephrine increases the risk of ventricular aritmii.Fenilefrin reduce the hypotensive effect of guanethidine which, in turn, increases the activity of alpha-adrenostimuliruyuschee fenilefrina.Antidepressanty, protivoparkinsonicheskogo agents, antipsychotics, phenothiazine derivatives increase the risk of urinary retention, dry mouth, zaporov.Odnovremennoe assignment GCS with phenylephrine increases the risk of glaukomy.Pri applied simultaneously with cardiac glycosides digoxin and may increase the risk of cardiac arrhythmias or heart pristupa.Askorbinovaya acid increases the risk of crystalluria in the treatment of salicylates and sulfonamides short-acting, slow renal excretion of acid, increases in conducting drugs having an alkaline reaction (including alkaloids), reduces blood levels of oral kontratseptivov.Etanol promotes acute pankreatita.Mielotoksichnye medicaments amplify manifestation gematotoksichnosti drug.
Overdose
In the case of drug overdose Koldreks® hotra (even with a good state of health) should take into account the risk of serious damage deferred pecheni.Simptomy symptoms caused by paracetamol: within 24 hours – paleness of the skin, nausea, vomiting, anorexia, abdominal pain; for 12-48 hours can manifest signs of liver disease, signs of impaired glucose metabolism and metabolic acidosis. Toxic effects in adults is possible after simultaneous reception of more than 10 g paracetamol – increase in liver transaminases, clinical liver disease is manifested after 1-6 days. In case of severe poisoning can develop severe liver failure until liver encephalopathy, coma and death. Acute renal failure with acute tubular necrosis, which diagnostsiruetsya of severe pain in the lumbar region, hematuria and proteinuria, may develop without severe hepatic dysfunction. There are reports of cardiac arrhythmias and pancreatitis overdose paratsetamola.V early period of symptoms may be limited to nausea or vomiting and may not reflect the degree of the severity of overdose or the risk of internal injury organov.Lechenie: within the first hour after the alleged overdose expedient appointment of activated carbon inside. After 4 hours or more after the intended overdosing is necessary to determine plasma concentrations of paracetamol (acetaminophen earlier determination of concentration can be misleading). The specific antidote for poisoning by paracetamol – acetylcysteine. acetylcysteine ​​treatment may be up to 24 hours after ingestion of paracetamol, however, the maximum hepatoprotective effect can be obtained for the first 8 hours after the overdose. After that, the effectiveness of antidote drops sharply. may be administered in case of necessity acetylcysteine ​​/ in. In the absence of emesis alternative embodiment (without the possibility of quick inpatient care) is the designation methionine inside. Treatment of patients with severe hepatic dysfunction at 24 hours after ingestion of paracetamol should be carried out together with specialists poison center or specialized separation pecheni.Simptomy diseases caused by phenylephrine: possible irritability, headache, dizziness, insomnia, increased blood pressure, nausea, vomiting, anxiety , reflex bradycardia. In severe cases an overdose may develop hallucinations, confusion, seizures, arrhythmias. Overdosing phenylephrine can cause symptoms similar to side deystviem.Lechenie: symptomatic therapy, with severe hypertension use of alpha-blockers such as fentolamin.Simptomy due ascorbate: ascorbic acid in high doses (3000 mg) may cause temporary osmotic diarrhea and disruption of the gastrointestinal tract, such as nausea, stomach discomfort. Manifestations overdose ascorbic acid can be categorized as those that cause severe liver disease resulting from overdose paratsetamola.Lechenie: symptomatic, forced diurez.Pri first sign of overdosing is necessary to immediately seek medical help, even if no distinct poisoning symptoms.
pharmachologic effect
Pharmacological group:
N02BE51
Pharmacodynamics:
Combined means whose action is due to its constituent komponentami.Paratsetamol is an analgesic and antipyretic agent. Its mechanism of action is presumed the suppression of prostaglandin synthesis, preferably in the central nervous sisteme.Paratsetamol it has an extremely small influence on prostaglandin synthesis in peripheral tissues, it does not change the water and electrolyte metabolism and does not damage the mucosa of the gastrointestinal tract. This paracetamol property makes the drug particularly suitable for patients with diseases of the gastrointestinal tract in history (e.g., patients with gastrointestinal bleeding history or elderly patients) or in patients receiving concomitant drug treatment, in which the suppression of the synthesis of peripheral prostaglandins may be undesirable. phenylephrine hydrochloride – sympathomimetic agent, whose action is directed to stimulation of adrenergic receptors (alpha advantageously adrenoretse tori), which reduces the swelling of the nasal mucosa and nasal relief dyhaniya.Askorbinovaya acid (vitamin C) compensates for the increased need for vitamin C at a “cold” and flu, particularly in the initial stages of the preparation zabolevaniya.Vhodyaschie components do not cause drowsiness and do not break concentration.
Pharmacokinetics:
Acetaminophen is rapidly and almost completely absorbed from the gastrointestinal tract, the distribution in the body fluids relative ravnomerno.Metaboliziruetsya predominantly in the liver with the formation of several metabolitov.T1 / 2 for receiving a therapeutic dose amounts to 2-3 hours. The main amount of the drug is excreted after conjugation in the liver. In unaltered allocated not more than 3% of the dose received paratsetamola.Fenilefrin poorly absorbed from the gastrointestinal tract and undergoes first pass metabolism in the intestine and in the liver by the action of MAO. When receiving phenylephrine inwardly bioavailability ogranichena.Vyvoditsya urine almost entirely in the form of a conjugate kisloty.Askorbinovaya sulfuric acid is readily absorbed from the gastrointestinal tract, binding to plasma proteins – 25%. Distribution in the body tissues shirokoe.Metaboliziruetsya in liver is excreted in the urine as unchanged oxalate and acid vide.Askorbinovaya adopted in excessive amounts, rapidly excreted unchanged in the urine.
Pregnancy and breast-feeding
BeremennostPreparat should not be used during pregnancy without first consulting your doctor!
In studies conducted in animals and humans, did not reveal any risk of the use of paracetamol during pregnancy or negative effects on intrauterine development ploda.Dostatochnye data on the effect of drugs containing phenylephrine, on pregnancy otsutstvuyut.Period thoracic vskarmlivaniyaPreparat should not be used in breastfeeding without first consulting your doctor!
Paracetamol crosses the placental barrier and into breast milk. In studies conducted on humans, there was no evidence of any negative impact on the child’s body through breast vskarmlivanii.Fenilefrin can pass into breast milk.
Conditions of supply of pharmacies
Without recipe
side effects
Determining the frequency of side effects: very common (> 1/10), common (> 1/100 and
special instructions
The patient should be informed that if symptoms persist after 5 days of use of the drug should stop taking it and consult with vrachom.Preparat should be taken only at the recommended dozah.Patsient should stop taking the drug and consult a doctor immediately if you experience the following side effects -allergicheskie reactions: itching or redness of the skin, respiratory embarrassment or edema of lips, tongue, throat, or face; -syp or peeling of the skin, the formation of ulcers in the mouth; and -sinyaki Whether bleeding; vision -poterya. This may be due to increased intraocular pressure. Very rarely, but most likely this side effect observed in patients with glaucoma; -oschuschenie palpitations or increased heart rate or heart rhythm disorders; -zatrudneniya when urinating. In most cases this side effect observed in patients with prostatic hypertrophy zhelezy.Ne should take the drug, if the previously observed respiratory disorders during reception of acetylsalicylic acid or other NPVP.Preparat should not be taken simultaneously with other preparations containing paracetamol, as well as other non-narcotic analgesics (metamizole sodium ), NSAIDs (aspirin, ibuprofen), barbiturates, anticonvulsant drugs, rifampicin and chloramphenicol, sympathomimetics (such to to decongestants, agents that suppress appetite, amphetamine-like psychostimulant agents), with other agents for the relief of cold symptoms and grippa.Pri conduct tests to determine the uric acid in the blood glucose iurovnya the patient should inform the doctor about the use of the drug Koldreks® Hawtrey, because preparation may distort the results of laboratory tests that measure the concentration of glucose and uric kisloty.Pered drug intake Koldreks® hotra (lemon) need to consult a doctor in case of: -priema metoclopramide, domperidone (used to eliminate nausea and vomiting) or cholestyramine used to reduce the concentration of cholesterol blood; -priema medications for reducing blood clotting (e.g., warfarin), – observance of a diet low in sodium – each sachet contains 0.12 g of sodium; -heavy communicable GOVERNMENTAL disease (including sepsis) in patients with deficiency of glutathione, as the intake of paracetamol may increase the risk of metabolic acidosis, features which are the violation frequency and depth of breathing, accompanied by a feeling of breathlessness (dyspnea), nausea, vomiting, loss of appetite. If a patient finds a such, you should immediately consult a vrachu.Patsientam suffering from phenylketonuria should not take Koldreks® Hawtrey (lemon-honey), because it contains aspartame, a source of phenylalanine. Prior to receiving drug Koldreks® hotra (honey-lemon) need medical consultation in the following cases: -priema warfarin or other anticoagulants; -priema drugs to control blood pressure, such as beta-blockers; -priema digoxin or other cardiac glycosides for the treatment of heart failure ; -priema drugs for reducing appetite or psychostimulants; -priema drugs for the treatment of depression (tricyclic antidepressants – amitriptyline); – receiving metoclopramide, domperidone (used for elimination of nausea and vomiting) or cholestyramine, ispolzuemyydlya lowering cholesterol in blood -with necessary compliance giponatrievoy diets (each sachet contains 0.12 g of sodium) .Vo prevent paracetamol liver toxicity should not be combined with reception of alcoholic beverages, as well as taking persons chronically alkogol.Vliyanie drink on the ability to drive vehicles and mehanizmamiPri receiving drug at the recommended doses has no effect on the ability to control the transport cFe stvami and mechanisms, as well as engage in other potentially hazardous activities that require concentration and psychomotor speed reactions. If dizziness is not recommended to drive vehicles or operate machinery.
Storage conditions
The drug should be stored in reach of children at a temperature not higher than 25 ° C.
Dosing and Administration
To receive vnutr.Ne exceed this dose!
Should apply the lowest dose necessary to achieve the effect!
The minimum interval between doses Koldreks® hotra preparation should be at least 4 ch.Soderzhimoe 1 sachet poured into a mug, pouring hot water, stir until rastvoreniya.Esli necessary, add cold water and sahar.Vzroslye (including elderly) and children over 12 years: inside, a single dose – 1 sachet. Repeated application of the drug may not earlier than after 4-6 hours and no more than 4 times / day. The maximum daily dose should not exceed 4 sachets. The maximum duration of the drug without consulting your doctor should not exceed 5 dney.Ne taken concurrently with other paratsetamolsoderzhaschimi means, decongestants and means to alleviate the symptoms of “cold” and the flu, as well as ethanol-containing media and napitkami.Esli while taking the drug symptoms persist , you need to consult a doctor.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

GlaxoSmithKline Helsker

There are no reviews yet.

Add your review