Klindovit gel naruzhn.prim-I 1% 30g tube

Description

Composition
Active substance:
100 g of gel contains:: clindamycin phosphate, clindamycin, based on – 1 g ;.
Excipients:
Methyl parahydroxybenzoate (Nipagin), allantoin, disodium lauriminodipropionata tocopheryl phosphate, propylene glycol, macrogol-400 (polyoxyethylene-400), carbomer copolymer, carbomer interpolymer, sodium hydroxide, purified water.
Description:
Colorless, almost transparent gel with a specific smell. Presence of opalescence.
Product form:
Gel for external application of 1%.
30 g in a tube of aluminum. Each tube together with instructions for use in a stack of cardboard.
Contraindications
Hypersensitivity to clindamycin or lincomycin history; Crohn’s disease, ulcerative colitis and pseudomembranous (including history).
Carefully
Age 12 years (experience of missing), lactation.
Caution should be used in patients with allergy, and while taking muscle relaxants.
Dosage
1 %
Indications
The drug used for the treatment of acne (acne vulgaris).
Interaction with other drugs
Clindamycin and erythromycin antagonists are, therefore is not suitable for the simultaneous use of these antibiotics.
Cross-resistance exists between clindamycin and lincomycin.
It may increase the effects of muscle relaxants, disrupting neuromuscular transmission.
Overdose
No data available.
pharmachologic effect
Pharmacological group:
Lincosamide antibiotic.
Pharmacodynamics:
Clindamycin – group lincosamides antibiotic, active against all strains of Propionibacterium acnes, the minimum inhibitory concentration (MIC) – 0.4 g / ml.
It inhibits the synthesis of proteins in microbial cell through interaction with the 50S-ribosomal subunits.
Clindamycin phosphate is inactive in vitro, but after application to the skin rapidly hydrolyzed phosphatases in the ducts of the sebaceous glands to form clindamycin having antibacterial activity. After application to the skin the amount of free fatty acids on the skin surface is reduced from about 14 to 2%.
Pharmacokinetics:
Clindamycin is rapidly accumulates in the comedones, which exhibits antibacterial activity. The average concentration of the antibiotic in the contents comedones after application of the gel significantly more than in the minimum inhibitory concentration for all strains of Propionibacterium acnes – causative agent of acne. After application to the skin of 1% clindamycin phosphate gel in plasma and urine was determined by very low concentrations of clindamycin.
Pregnancy and breast-feeding
Perhaps cutaneous application of the gel during pregnancy if the expected benefit to the mother outweighs the potential risk to the fetus. If necessary, use during lactation is recommended the termination of breastfeeding.
Conditions of supply of pharmacies
Without recipe.
side effects
The drug is generally well tolerated, but in the local application of the gel may result in irritation (the site of application), burning, itching, dry skin, erythema, peeling, increased sebum, contact dermatitis. When resorption there is a possibility of pseudomembranous enterocolitis.
special instructions
In applying the drug should avoid contact with the eyes and oral cavity, and after application of the gel should wash their hands.
Storage conditions
At a temperature of 15 to 25 ° C. Keep out of the reach of children.
Dosing and Administration
Outwardly. Gel thin layer to the affected area pretreated and dried skin 2-3 times a day.
The course of treatment to obtain satisfactory results, treatment should be continued for 6-8 weeks and can be extended to 6 months if necessary.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist