Klindatsin suppositories vaginas. 100mg 3 pcs

Description

Composition Active substance 1 suppository contains: active substance – clindamycin phosphate, clindamycin, based on – 100 mg. Excipients: semi-synthetic glycerides (such as “Estarinum”, “Witepsol” or “Suppotsir”) ,. Description: White or white with a yellowish tinge of cylindrical-shaped suppositories. On the longitudinal section there are no blotches, tolerance of air and porous rod and funnel-shaped grooves. Product: Vaginal suppositories 100 mg. 3 suppository in blisters. 1 blisters together with instructions for use placed in a pile of cardboard. Hypersensitivity, pregnancy I trimester. Indications Bacterial vaginosis caused by microorganisms susceptible to clindamycin. Interaction with other drugs increases the effects of drugs rifampin, aminoglycosides – streptomycin, gentamicin, enhances muscle relaxation caused n-holinoblokatorami. Incompatible with erythromycin, ampicillin, diphenylhydantoin, barbiturates, aminophylline, calcium gluconate and magnesium sulfate. Overdosing the low absorption of the drug overdose unlikely. The drugs group: Antibiotic – lincosamide. Pharmacodynamics: Bacteriostatic antibiotic lincosamides group has a broad spectrum of activity, binds to 50S ribosomal subunit and inhibits the membrane in the microbial cell protein synthesis. For a number of gram-positive cocci possible bactericidal action. It is active against Staphylococcus spp. (Including Staphylococcus epidermidis, producing and producing no penicillinase), Streptococcus spp. (Excluding Enterococcus faecalis), Streptococcus pneumoniae, Corynebacterium diphtheriae, Mycoplasma spp., Microaerophilic and anaerobic gram-positive cocci (including Peptococcus spp., And Peptostreptococcus spp.), Clostridium perfringens, Clostridium tetani, Bacteroides spp. (Including Bacteroides fragilis and Prevotella melaninogenica), Fusobacterium spp., Propionibacterium spp., Eubakterium and Actinomyces israelii. Most strains of Clostridium perfringens susceptible to clindamycin, but other. Species Clostridium spp. (Including Clostridium sporogenes, Clostridium tertium) resistant to its action in connection with infections caused by Clostridium spp., Antibiogram determination recommended. Between clindamycin and lincomycin cross-resistance exists. Pharmacokinetics: After a single intravaginal administration of 100 mg of clindamycin 4% of the administered dose undergoes systemic absorption. Maximum plasma concentration – 20 ng / ml. Pregnancy and breast-feeding Clindamycin crosses the placenta into the circulatory system of the fetus. Excreted in breast milk. Intravaginal clindamycin during pregnancy is possible only when the intended benefits to the mother outweighs the potential risk to the fetus. It is recommended to be careful in appointing lactating women (at the time of treatment stop breastfeeding). Conditions of supply of pharmacies without a prescription. Side effects With the genitourinary system: cervicitis, vaginitis, vulvovaginal irritation. From the side of hematopoiesis: rarely reversible leukopenia, neutropenia, eosinophilia, agranulocytosis, thrombocytopenia. Allergic reactions: maculo-papular rash, urticaria, pruritus. When resorption there is a possibility of systemic side effects, including rare cases – pseudomembranous enterocolitis. Cautions vaginal suppositories are not recommended for use concomitantly with other intravaginal drug. The drug has no effect on the rate of the reaction of drivers of vehicles and persons serving the installation, require special attention. Storage conditions in a dry, dark place at a temperature of from 15 to 25 ° C. Keep out of the reach of children. Dosing and dose Intravaginal. Before use, one suppository was freed from the contour packaging film pre-cutting along the contour of the suppository is administered possible deeply in the vagina, in the supine position. 1 according to one suppository once per day before going to bed for 3-7 consecutive days. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist