Klindatsin b prolong cream vaginas. prolong. 2% + 2% 20g tuba

$69.00

Klindatsin b prolong cream vaginas. prolong. 2% + 2% 20g tuba

5 in stock

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Description

Composition Active ingredient: 100 g of cream contains: butoconazole nitrate in terms of 100% substance – 2 g; clindamycin phosphate in terms of 100% substance – 2,376 g, equivalent to 2g of clindamycin ;. Excipients: Euxyl PE 9010 Preservative (phenoxyethanol 90% etilgeksilglitserol 10%) – 0.5 g, equivalent to 0.45 g of phenoxyethanol, propylene glycol – 5 g isopropyl myristate – 8 g, tsetostearat macrogol (macrogol 20-cetostearyl ether) – 2 g of cetostearyl alcohol [60% cetyl alcohol, stearyl alcohol 40%] – 6 g, gidroksipropildikrahmalfosfat – 8 g sodium hydroxide – 0.26 g purified water – up to 100 g Description: Cream from nearly white to white with grayish a touch of color with a specific smell. Product: vaginal cream 2% + 2%. 6 or 20 g of aluminum into a tube. Each tube 6 together with 1 g of the applicator and the instruction on use or on the tube 20 together with 3 g of applicators and application instructions are placed in a pile of cardboard. Hypersensitivity to clindamycin, lincomycin, butoconazole or any component of the formulation; Crohn’s disease, ulcerative colitis and pseudomembranous (including history); Children up to age 18 years. Precautions Allergic diseases, concomitant use of muscle relaxants. Dosage 2% + 2% Indications Bacterial, fungal and mixed vaginosis caused by susceptible microorganisms to the drug. Interaction with other drugs between clindamycin and erythromycin marked antagonistic interaction. Incompatible with solutions containing vitamin B complex, aminoglycosides, ampicillin, calcium gluconate and magnesium sulfate. Overdosing When drug overdose intravaginal application is not installed. The drugs group: antimicrobial and antifungal agent. Pharmacodynamics: butoconazole – imidazole derivative, has fungicidal activity against fungi Candida, Trichophyton, Microsporum, Epidermaphyton and some gram-positive bacteria. The most effective in candidiasis. Blocking the formation of ergosterol in the cell membrane of lanosterol that increases the permeability of the membrane that leads to lysis of cells of the fungus. Clindamycin – a bacteriostatic antibiotic from the group of lincosamides, has a wide spectrum of activity, binds to 50S ribosomal subunit and inhibits the membrane in the microbial cell protein synthesis. For a number of gram-positive cocci possible bactericidal action. In in vitro conditions susceptible to clindamycin following microorganisms causing bacterial vaginosis: Gardnerella vaginalis, Mobiluncus spp, Mycoplasma hominis, Bacteroides spp, Peptostreptococcus spp… The hydrophilic cream base formulation provides a gel-like consistency at a temperature of 35-40 ° C. In intravaginal application, the cream does not melt, and therefore the active agents are in the mucosa of the vagina for 1-3 days. Cross-resistance exists between clindamycin and lincomycin. Pharmacokinetics When intravaginal administration absorbed about 1.7% of the administered dose butoconazole and 4% of the administered dose of clindamycin. Maximum plasma concentration achieved butoconazole after 13 h and is 2-18,6 ng / ml. The maximum plasma concentration of clindamycin is 20 ng / ml. Butoconazole undergoes extensive metabolism partly excreted by the kidneys and intestines. Pregnancy and lactation Use of the drug during pregnancy and lactation is possible only if the potential benefit to the mother outweighs the risk to the fetus or child. Conditions of supply of pharmacies by prescription. Side effects The drug is generally well tolerated, but may cause irritation at the injection site, burning, itching, pain and swelling of the mucous membrane of the vagina, pain / cramps in the lower abdomen, the development of allergic reactions. Special instructions: If clinical signs of infection persist after treatment is completed, there should be repeated microbiological examination for the detection of the pathogen and confirm the diagnosis. The appearance of the vaginal mucosa irritation or pain, is an indication for treatment discontinuation. Vaginal Cream should not be used concomitantly with other intravaginal drug. Storage conditions at a temperature of from 15 to 25 ° C. Keep out of the reach of children. Dosing and dose introduced intravaginally with an applicator. Applied 1 time a day, preferably before bedtime. The recommended dose is one full applicator (5 g of a cream, which corresponds to 100 mg of butoconazole nitrate, clindamycin and 100 mg). The course of treatment – daily for 3 days. Disposable applicators supplied with the package, designed for the proper administration of the cream into the vagina. 1. Remove the cap of a tube of cream. Screw the plastic applicator on the threaded neck of the tube. 2. Squeezing the tube at the opposite end, gently squeeze out the cream into the applicator. Piston applicator moves independently as required filling volume. The applicator is filled when the piston reaches the stop. 3. Lying on your back, take the applicator horizontally and insert it into the vagina as far as possible, but so as not to cause discomfort. 4. Slowly push the plunger all the way. 5. Carefully remove the applicator from the vagina, and discard it. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist 3. Lying on your back, take the applicator horizontally and insert it into the vagina as far as possible, but so as not to cause discomfort. 4. Slowly push the plunger all the way. 5. Carefully remove the applicator from the vagina, and discard it. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist 3. Lying on your back, take the applicator horizontally and insert it into the vagina as far as possible, but so as not to cause discomfort. 4. Slowly push the plunger all the way. 5. Carefully remove the applicator from the vagina, and discard it. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

QUINACRINE

Use

infection

Release Form

cream

Active ingredients

butokonazol + clindamycin

Dosage

2% + 2%

Amount in a package

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