Ketosteril Tab n / a film about 100 pieces

Description

Composition
Active substance:
Isoleucine alpha ketoanalog (DL-methyl-oxo-2-calcium valerinat) 67 mg leucine alpha ketoanalog (methyl-4-oxo-2-calcium valerinat) 101 mg phenylalanine alpha ketoanalog (oxo-2-phenyl-3-calcium propionate) 68 mg valine alpha ketoanalog (methyl-oxo-2-calcium butyrate) 86 mg methionine alpha hydroxy (DL-hydroxy-2-calcium methylbutyrate) 59 mg L-lysine monoacetate 105 mg L-threonine 53 mg L-tryptophan 23 mg L-histidine 38 mg L-tyrosine 30 mg.
Excipients:
Corn starch 44 mg talc 6 mg Povidone 19.57 mg Colloidal silicon dioxide 4.4 mg Magnesium stearate 15.0 mg macrogol 6000 12.8 mg 43.2 mg Povidone soluble
Tablet Coating: talc 9.10 mg Macrogol 6000 1.48 mg Quinoline Yellow (E104) 0.72 mg of methyl methacrylate, dimethylaminoethyl methacrylate, and 5.9 mg of butyl methacrylate copolymer (Eudragit E 12.5) Triacetin 0.43 mg Titanium dioxide 7.4 mg
The total nitrogen content of the tablet 36 mg
The calcium content of 1.25 mmoles per tablet = 50 mg.
Description:
Oblong, biconvex film-coated tablets are yellow.
Product form:
Tablets, film-coated. 20 tablets in blister Al / PVC. 5 in a sealed blister pack of Al / PVC. 1 package in carton pack with instructions for use.
Contraindications
Hypercalcemia, impaired metabolism of amino acids, hypersensitivity. When hereditary phenylketonuria should take into account that the product contains phenylalanine.
Indications
Protein-energy malnutrition, prevention and treatment of disorders in adults and children from 3 years, due to changes in the protein metabolism in chronic renal failure, and limitation of protein in the diet. Mainly used in patients with chronic renal failure with a glomerular filtration rate below 25 ml / min, which does not exclude use in the glomerular filtration rate and greater than 25 ml / min.
Interaction with other drugs
Simultaneous administration of drugs containing calcium, can lead to increased levels of calcium in blood serum. By decreasing uremic symptoms influenced Ketosterila® dose simultaneously designated aluminum hydroxide should be correspondingly reduced. It is necessary to monitor the reduction in phosphate levels in the blood serum. In order not to disturb the intestinal absorption, should not be taken together with Ketosterilom® drug capable of forming a difficultly soluble calcium compound (e.g., tetracyclines, quinolones, preparations containing iron, fluoro and estramustine). Ketosterila® between reception and such preparations must be an interval of at least 2 hours.
pharmachologic effect
Pharmacological group:
Kidney failure means the treatment.
Pharmacological properties:
Combined preparation. It provides a complete supply of essential amino acids with minimal introduction of nitrogen. Ketone analogs of amino acids in the body enzymatically transaminiruyutsya in corresponding L-amino acids, splitting with urea. The preparation promotes recycling nitrogenous metabolic products of protein anabolism while reducing urea concentration in serum. Improves nitrogen metabolism. Reduces the concentration of blood potassium ions, magnesium and phosphate. The systematic use of the drug observed improvement in patients with chronic renal insufficiency. In some cases it is possible to delay the start of dialysis.
Conditions of supply of pharmacies
By prescription.
side effects
In some cases, may develop hypercalcemia. It is recommended to reduce the intake of vitamin D. If hypercalcemia persists, reduce the dose Ketosterila®, as well as other sources of calcium.
special instructions
It is not enough experience with pregnancy and lactation. Ketosteril® should be taken at meal time for its better absorption and conversion into the corresponding amino acids.
It is necessary to regularly monitor the level of calcium in blood serum. It is required to ensure adequate caloric intake.
In some cases, may cause allergic reactions in patients with hypersensitivity to the drug.
Storage conditions
Store at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
For oral administration. Adults and children 3 years of 1 tablet per 5 kg body weight per day or 0.1 g / kg body weight per day. Unless otherwise specified, take 3 times a day during meal time. Swallow without chewing.
Duration of treatment: Ketosteril® administered throughout the period when the glomerular filtration rate below 25 ml / min. In predialysis period recommended content in food protein no more than 40 grams of protein per day depending on the degree of chronic renal failure. In patients on dialysis, protein intake should be in accordance with accepted standards.
The usual dose for an adult (70 kg body weight) is 4-8 tablets three times a day.
The usual dose for children – 1 tablet per 5 kg body weight per day.
Recommended protein content in food for children aged 3 to 10 years – 1,4-0,8 g / kg body weight per day, for children 10 years – 1,0-0,6 g / kg body weight per day.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist