Ketorol gel naruzhn.prim-I 2% 30g tube

Description

Composition
Active substance:
ketorolac tromethamine (ketorolac trometamol) – 20 mg;
Excipients:
Propylene glycol 300 mg, 150 mg of dimethylsulfoxide, 20 mg carbomer 974P, sodium methyl parahydroxybenzoate 1.8 mg propyl parahydroxybenzoate 0.2 mg sodium, tromethamine (Trometamol) 15 mg Purified water 390 mg, flavor “Indus Drimon” (triethyl citrate 0.09% , castor bean seed oil 0.14% isopropyl myristate 0.3% 0, diethylphthalate 24.15%) 3 mg, ethanol 50 mg, 50 mg glycerol.
Description:
Homogeneous transparent or translucent gel with a characteristic odor.
Product form:
Gel for external use 2%.
30 g of laminated aluminum tube, equipped with a septum for controlling the first opening.
Tube with instructions for use in a cardboard pack.
Contraindications
– Increased sensitivity to ketorolac or other components of the formulation;
– moist dermatitis, eczema, open wounds or infected (in the place of application of the gel);
– full or partial combination of asthma, recurrent nasal polyposis or paranasal sinuses and intolerance to acetylsalicylic acid and other NSAIDs (indicating a history of bronchospasm, urticaria and rhinitis caused by the intake of acetylsalicylic acid);
– pregnancy (III trimester);
– lactation (lactation);
– Children up to age 16 years.
Carefully:
Exacerbation hepatic porphyria, erosive and ulcerative lesions of the gastrointestinal tract, severe renal / hepatic failure, chronic heart failure, bronchial asthma, advanced age, pregnancy (I and II trimester).
Dosage
2%
Indications
Topical application for the relief of pain:
– trauma (contusion of the soft tissues, inflammation of the soft tissues, including post-traumatic origin, ligament damage, bursitis, tendinitis, epicondylitis, synovitis);
– pain in muscles (myalgia) and joint pain (arthralgia), neuralgia, radiculitis, rheumatic diseases.
It is intended for symptomatic therapy, reducing the intensity of pain and inflammation at the time of use, does not affect the progression of the disease.
Interaction with other drugs
It is possible pharmacokinetic interactions with drugs competing for the connection to plasma proteins.
Caution must be exercised while the use of ketorolac with digoxin, phenytoin, lithium preparations, diuretics, cyclosporine, methotrexate, other NSAIDs, antihypertensive and antidiabetic agents.
Before use, the gel should consult with your doctor if you are using these funds or are under a doctor’s supervision.
Overdose
gel have not been described cases of overdose. When receiving the random gel inside must be cleaned stomach (vomiting, administration of activated charcoal) and seek medical advice. Further treatment, if necessary, symptomatic.
pharmachologic effect
Pharmacological group:
Nonsteroidal anti-inflammatory drug (NSAID).
Pharmacological properties:
Nonsteroidal anti-inflammatory drug (NSAID), has a pronounced analgesic and anti-inflammatory effect. The mechanism of action is related to non-selective inhibition of cyclooxygenase (COX) – COX-1 and COX-2 catalyzes the formation of prostaglandins from arachidonic acid, which play an important role in the pathogenesis of pain, inflammation and fever. Ketorolac is a racemic mixture of [-] S and [+] R enantiomers with the analgesic effect is due to [-] S shape.
When applied topically cause weakening or disappearance of pain at the site of gel application, including joint pain at rest and during motion, reduces morning stiffness and swelling of joints. Increases the range of motion.
Conditions of supply of pharmacies
Without recipe.
side effects
Local reactions: itching, rash, peeling.
If there are any adverse reactions should stop using the product and consult a physician.
When applying the gel to extensive areas of skin is not excluded development of systemic side reactions, heartburn, nausea, vomiting, diarrhea, gastralgia, ulceration of mucosa of the gastrointestinal tract, increased activity “liver” transaminase; headache, dizziness; fluid retention, hematuria; allergic reactions (anaphylaxis, skin rash); thrombocytopenia, leukopenia, anemia, agranulocytosis, prolongation of bleeding time.
special instructions
The drug is recommended to be applied only to intact skin while avoiding contact with open wounds. Avoid contact with the gel in the eye and other mucous membranes. Do not use the gel under airtight dressings. After application of the gel Wash hands with soap. Tightly close the tube after use of the gel.
Storage conditions
At temperatures above 25 ° C. Do not freeze!
Keep out of the reach of children!.
Dosing and Administration
For external use only.
Before applying the gel to wash and dry the surface of the skin. Apply a thin uniform layer of the gel column of length about 1-2 cm to the area of ​​maximum pain 3-4 times per day. Application preparation is soft massaging movements by which the distribution of gel occurs in the skin over the affected area.
Re-use preparation should not earlier than 4 h. Apply the drug is not more than 4 times per day. It does not exceed this dose.
If symptoms persist or worsen, or there is no improvement after 10 days of using the product, you must stop treatment and seek medical advice. Do not apply the gel more than 10 days without consulting a doctor.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist