Karsil pills 35mg 80 pc

Description

Composition
Active substance:
Silybum marianum fruit extract, dry (equivalent silymarin) – 35,000 mg.
Excipients:
Core: lactose monohydrate (55.380 mg), wheat starch (55.380 mg), povidone (Kolidon 25) (1,650 mg), microcrystalline cellulose (67.000 mg), magnesium stearate (2.500 mg), talc (7.000 mg) of dextrose monohydrate (20.600 mg), sorbitol (4,130 mg), sodium bicarbonate (1,360 mg).
Sheath: tsellatsefat (0.840 mg), diethyl phthalate (0.600 mg), sucrose (162.190 mg), acacia gum (1.562 mg), gelatin (0.860 mg), talc (26.718 mg), titanium dioxide (4,820 mg), Macrogol (PEG 6000 ) (0.130 mg), Brown dye Opalyuks (sucrose, iron oxide red, iron oxide black, methyl and propyl parahydroxybenzoate, purified water) (2.250 mg), glycerol (0.030 mg).
Description:
Dragee biconvex shaped, film-coated with an outer layer of brown color and an inner layer of white. Kind of on a break from brownish zheltogodo light brown.
Product form:
Dragee 35 mg.
Packing 80 pcs.
Contraindications
Hypersensitivity to the current or any of the excipients of the drug. Children under 12 years of age.
Dosage
35 mg
Indications
– Toxic liver disease; – states after acute hepatitis; – Chronic hepatitis non-viral etiology; – hepatic steatosis (alcoholic and non-alcoholic); – In the treatment of cirrhosis of the liver; – Prevention of liver lesions by prolonged medication, alcohol, chronic intoxication (including professional).
Interaction with other drugs
Pharmacodynamic drug interactions Silymarin has no significant influence on the pharmacodynamics of other drugs. In a joint application of silymarin with oral contraceptives and drugs used in hormone replacement therapy, may reduce the effects of the latter.
Silymarin may enhance the effects of such drugs as diazepam, alprazolam, ketoconazole, lovastatin, vinblastine because of its inhibitory effect on cytochrome P 450. Clinical studies show little risk of possible pharmacokinetic interactions silymarin as an inhibitor of isozyme CYP3A4 and UGT1A1, cytostatics and that are substrates of these enzymes.
Overdose
No data on drug overdose. If you accidentally receiving a high dose is necessary to induce vomiting, gastric lavage using activated carbon and conduct symptomatic treatment if necessary.
pharmachologic effect
Pharmacodynamics:
Karsil® belongs to a group of hepatoprotective drugs. Contains dry extract of milk thistle fruit (equivalent silymarin), which is a mixture of 4 isomers flavonolignans: silibinin, silibinin isobutyl, silydianin and silychristin. The mechanism of action of the drug is still not clear. It is found that the hepatoprotective action of silymarin is caused competitive interaction with the toxins to the respective receptors in the hepatocyte membrane, showing thus membrane stabilizing effect. Silymarin has metabolic and cell-regulatory effects, regulating the permeability of cell membranes, inhibiting 5-lipoxygenase pathway, particularly leukotriene B4 (LTB4) as well as binding to reactive oxygen free radicals. Stimulates the synthesis of proteins (structural and functional) and phospholipids in infected hepatocytes, accelerating regenerative processes. The action of flavonoids, which belongs to silymarin, is also determined by their antioxidant and improves microcirculation effects. Clinically, these effects are expressed in the improvement of subjective and objective symptoms and normalization of hepatic function status (transaminases, gamma globulin, bilirubin). This leads to an improvement in the general state, decrease in complaints related to digestion, and in patients with reduced assimilation of food as a result of liver disease, leading to increased appetite and weight gain.
Pharmacokinetics:
After oral administration of silymarin slowly resorbed from the gastro-intestinal tract. Undergoes enterohepatic circulation. Not accumulates. In the study of silibinin, labeled C14, the highest concentrations are found in the liver and very small amounts – in the kidneys, lungs, heart and other organs. It is metabolized in the liver by conjugation. The bile as metabolites detected glucuronides and sulfates. The half-life time is 6 hours. Write mainly in bile (approximately 80%) as glucuronides and sulfates, and to a minor extent (about 5%) in the urine.
Pregnancy and breast-feeding
Do not use the drug during pregnancy and breastfeeding.
Conditions of supply of pharmacies
Without recipe.
side effects
The drug was well tolerated. Rarely the following side effects are: – the part of the gastrointestinal tract: nausea, dyspepsia, diarrhea. – Skin: in rare cases, possible allergic skin reactions – itching, rash, alopecia. Other: rarely can observe the strengthening of existing vestibular disorders. Side effects are transient and disappear after discontinuation of the drug.
special instructions
Precautions prescribed to patients with hormonal disorders (endometriosis, uterine fibroids, breast carcinoma, ovary and uterus, prostate carcinoma), due to the possible existence of estrogen-like effect of silymarin. The pharmaceutical preparation as an adjuvant contains wheat starch, which may constitute a risk of deterioration in patients with celiac disease (gluten enteropathy), and glycerol, which can cause headaches or irritable effect on the gastric mucosa with high doses.
Storage conditions
In a dry and dark place, at a temperature not higher than 25 ° C. Keep out of the reach of children!
Dosing and Administration
Dragees taken orally before meals, drinking plenty of water. The course of treatment continues for at least 3 months. Adults and children over 12 years: the treatment of serious liver begin with a daily dose of 420 mg (4 tablets 3 times a day). In milder cases and as maintenance therapy – 1-2 tablets 3 times a day. Prophylactically take 2-3 pills a day.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist