Kardionat Injection 100mg / 5ml ampoules 10 mL pc


Kardionat Injection 100mg / 5ml ampoules 10 mL pc



Active substance:
Meldonium dihydrate (trimethylhydrasine propionate dihydrate) based on the dihydrate without adsorbed moisture – 500 mg ;.
Water for injection – 5 ml.
Transparent colorless liquid.
Product form:
Injection of 100 mg / ml. 5 mL neutral glass ampoules.
5 vials are packed in blisters made of PVC film.
2 blisters together with instructions for use and the knife for opening the ampoule (in the case of ampoules point or ring breakup knife put) in a cardboard pack.
Hypersensitivity to the drug; increased intracranial pressure (in violation of the venous outflow and intracranial tumors); pregnancy, lactation, age under 18 years old.
100 mg / ml
In the treatment of ischemic heart disease (angina, myocardial infarction), congestive heart failure, kardialgiya on background dyshormonal myocardial dystrophy.
In the treatment of: cerebral blood flow (ischemic stroke, cerebrovascular insufficiency).
In complex therapy: acute circulatory disorder in the retina, hemophthalmus and retinal hemorrhages of varying etiology, thrombosis, central retinal vein and its branches, retinopathy of various etiologies (including diabetic and idiopathic) – only for administration parabulbarly.
Decreased performance, physical stress (including athletes).
Alcohol withdrawal syndrome (in the complex specific therapy).
Interaction with other drugs
Vasodilatig enhances the action and antihypertensive medications, cardiac glycosides. Due to the possible development of moderate tachycardia and hypotension, caution should be exercised when combined with nitroglycerin. nifedipine. alpha-blockers, antihypertensive drugs and peripheral vasodilators.
It can be combined with antianginal drugs, anticoagulants, antiplatelet agents, antiarrhythmics, diuretics, bronchodilators.
Symptoms: reduced blood pressure, headache, tachycardia, dizziness, weakness.
Treatment is symptomatic.
pharmachologic effect
Pharmacological group:
Metabolic means.
Structural analogue of gamma-butyrobetaine. Meldonium inhibits gamma butirobetaiigidroksilazu. which leads to a decrease in the synthesis of carnitine. restriction of transport in cells of long-chain fatty acids and prevents the accumulation of activated forms of unoxidized fatty acids – derivatives of acylcarnitine and atsilkofermenta A. ischemia restores the balance of delivery processes and oxygen consumption, activates glycolysis; prevents the violation of transport and reduction of adenosine triphosphate (AGF). By lowering the concentration of carnitine intensively synthesized gamma-butyrobetaine possesses vasodilating properties.
In the case of acute myocardial ischemic injury inhibits the formation of necrotic zone shortens the rehabilitation period. In chronic heart failure (CHF) increases exercise tolerance. When the voltage decreases the frequency of angina attacks. In acute and chronic ischemic disorders of cerebral blood circulation improves blood circulation in the ischemic focus, promotes redistribution of blood to the ischemic area. It is effective in the case of vascular and dystrophic pathology of the fundus. Has a tonic effect on the central nervous system, it contributes to the elimination of functional disturbances of somatic and autonomic parts of the nervous system in patients with chronic alcoholism during abstinence. Reduces the severity of symptoms of mental and physical stress.
After intravenous administration, the maximum concentration of drug in blood plasma is achieved immediately after administration. Data on bioavailability of the drug after intramuscular administration there. It is metabolized in the body into two major metabolites are excreted by the kidneys. half-life is 3 to 6 hours.
Pregnancy and breast-feeding
Do not use this drug during pregnancy and lactation.
Conditions of supply of pharmacies
On prescription.
side effects
Rarely – allergic reactions (redness, rash, itching, swelling), dyspepsia, tachycardia, decreased or increased blood pressure, arousal.
Very rarely – eosinophilia. general weakness.
special instructions
Precautions should be used drug for liver and / or kidney disease, especially for a long time.
Years of experience in the treatment of acute myocardial infarction and unstable angina Cardiac offices shows that meldonium preparation is not one of a number of acute coronary syndrome and its use is not absolutely necessary.
Effect pas ability to drive and maintain other mechanisms
No evidence of adverse effects on psychomotor speed meldonium reaction.
Storage conditions
At temperatures above 25 ° C.
Keep out of the reach of children.
Dosing and Administration
In view of the possibility of bringing a drug effect it is recommended to use in the morning.
Angina and myocardial infarction (in combination therapy) intravenous (i / v) 0.5-1 g of (5 – 10 ml of a solution of 100 mg / 1 ml injection) 1 time per day, then transferred to the ingestion of the drug.
Chronic heart failure (in combination therapy): in / 0.5-1 g (5 – 10 ml of solution for injection) once daily 1: treatment – 10 – 14 days, then transferred to the ingestion of the drug.
Cardialgia amid disgormonalioy myocardial dystrophy: in / 0.5-1 g (5 – 10 ml of solution for injections) 1 times a day or in / m to 0.5 g 1-2 times a day; course of treatment – 10 to 14 days, then move on ingestion of the drug.
Cerebral circulation (in combination therapy): an acute phase – in / 500 mg (5 ml of solution for injections) 1 times a day for 10 days, then a transition to oral; chronic cerebrovascular krovoobrascheniya`, / m to 500 mg (5 ml of solution for injections) 1 times a day; course of treatment 10-14 days, followed by a transition to the ingestion of the drug.
Vascular pathology fundus dystrophy and retina (in combination therapy): parabulbarno 0.5 ml solution for injection for 10 days.
Physical and mental overload: in / of 0.5 g (5 ml of solution for injections) 1 times a day; course of treatment – 10-14 days. If necessary, repeat the course in 2-3 weeks.
Alcohol withdrawal syndrome: in / 500 mg (5 ml of solution for injection), 2 times a day; course of treatment – 7-10 days.
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg


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