Izoprinozin tab 500mg 20 pieces

$14.93

Izoprinozin tab 500mg 20 pieces

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Description

Composition
Active substance:
Inosine pranobex (Isoprinosine) – 500 mg.
Excipients:
mannitol, wheat starch, povidone, magnesium stearate.
Description:
Oblong tablets biconvex forms white or almost white color with a slight amine odor, with the mark on one side.
Product form:
Tablets of 500 mg.
10 tablets in blister PVC / PVDC and aluminum foil.
2 in the blister pack carton along with instructions for use.
Contraindications
– Increased sensitivity to the drug;
– gout;
– urolithiasis disease;
– arrhythmia;
– Chronic renal failure;
– Children under 3 years old (weight 15-20 kg).
Dosage
500 mg
Indications
– Treatment of influenza and other acute respiratory viral infections;
– infections caused by the herpes viruses of the 1st, 2nd, 3rd and 4th types labial and genital herpes, herpetic keratitis, herpes zoster, chickenpox, infectious mononucleosis caused by Epstein-Barr virus;
– cytomegalovirus infection;
– measles, severe;
– human papillomavirus infection: laryngeal papilloma / vocal cords (the fibrous type), HPV infection of the genitals in both men and women, the warts;
– Molluscum Contagiosum.
Interaction with other drugs
Immunosuppressive drugs may reduce the effectiveness of the drug. Xanthine oxidase inhibitors and uricosuric agents (including diuretics) may contribute to increase risk levels of uric acid in the blood serum of patients taking Isoprinosine.
Overdose
cases of overdose have not been described.
pharmachologic effect
Pharmacological group:
immunostimulatory agent.
Pharmacological properties:
Isoprinosine – synthetic purine derivative complex having immunopotentiating activity and non-specific antiviral effect.
Restores lymphocyte function in immunosuppression conditions, increases in the population blastogenesis monocytic cells stimulates expression of membrane receptors on the surface of T-helper cells, prevents the decrease in activity of lymphocyte cells under the influence of glucocorticoids, normalizes the inclusion of thymidine. Isoprinosine has a stimulating effect on the activity of cytotoxic T lymphocytes and natural killer cells, T-suppressor function of T-helper cells and increases immunoglobulin production (Ig) G, interferon-gamma, interleukin (IL) -1 and IL-2, reduces the formation of proinflammatory cytokines – IL-4 and IL-10 potentiates the chemotaxis of neutrophils, monocytes and macrophages.
The drug shows antiviral activity in vivo against viruses Herpes simplex, cytomegalovirus and measles virus, virus T-cell lymphoma human type III, poliovirus, influenza A and B, ECHO-virus (human virus enterotsitopatogenny), and equine encephalitis encephalomyocarditis. The mechanism of the antiviral action of isoprinosine associated with inhibition of viral RNA and digidropteroatsintetazy enzyme involved in the replication of some viruses, virus enhances depressed lymphocyte mRNA synthesis, which is accompanied by inhibition of the biosynthesis of viral RNA and translation of viral proteins, increases lymphocyte products having antiviral properties of interferon alpha and gamma. When combined appointment enhances the action of alpha-interferon, antiviral agents, acyclovir and zidovudine.
Pharmacokinetics:
After oral administration the drug is well absorbed from the gastrointestinal tract.
The maximum concentration of the ingredients in the blood plasma determined after 1-2 hours. Rapidly metabolized and excreted through the kidneys. It metabolized analogous endogenous purine nucleotide to form uric acid. N-N-dimethylamino-2-propranolon metabolized to N-oxide and the steam-to-atsetamidobenzoat -up atsilglyukuronida. Not revealed accumulation of the drug in the body. The half-life of 3.5 hours for N-N- dimethylamino-2-propranolona -for 50 minutes and steam-atsetamidobenzoata. The elimination of the drug and its metabolites are excreted occurs within 24-48 hours.
Pregnancy and breast-feeding
Do not use the drug during pregnancy and lactation, as safety of use has not been studied.
Conditions of supply of pharmacies
On prescription.
side effects
The incidence of side effects after treatment is classified according to WHO recommendations.
Often:> = 1% and
Sometimes:> = 0.1%, and
Gastro-intestinal tract: often – nausea, vomiting, epigastric pain, sometimes –
diarrhea, constipation.
Of the liver and biliary tract: often – a temporary increase in transaminases and alkaline phosphatase in the blood plasma, increasing concentrations of urea in blood plasma.
Skin and subcutaneous tissue: often – itching.
From the nervous system: often – headache, dizziness, weakness; sometimes –
drowsiness, insomnia.
From the urinary system: rarely – polyuria.
On the part of the musculoskeletal system and connective tissue disorders: often – pain in the joints,
exacerbation of gout.
special instructions
After 2 weeks of izoprinozin should hold control the concentration of uric acid in blood serum and urine.
Chronic administration after 4 weeks of each month it is advisable to carry out monitoring of liver and kidney function (activity of transaminases in the blood plasma, creatinine, uric acid).
It is necessary to control the level of uric acid in blood serum when assigning izoprinozin in combination with drugs that increase the levels of uric acid or preparations violating kidney function.
Effects on ability to drive vehicles and other mechanisms
No specific contraindications.
Storage conditions
List B. Store at a temperature not higher than +25 ° C in a dry place, protected from light.
Keep out of the reach of children.
Dosing and Administration
The tablets are taken orally after meal with a little water.
The recommended dose for adults and children 3 years of age (body weight 15-20 kg) of 50 mg / kg per day, divided into 3-4 doses.
Adults – 6-8 tablets per day, children – 2.1 tablets per 5 kg / body weight per day. In severe infections the dose may be increased individually up to 100 mg / kg of body weight per day, divided into 4-6 doses. The maximum daily dose for adults 3-4 g / day, for children – 50 mg / kg / day.
duration of treatment
Acute diseases: the duration of treatment in adults and children is usually between 5 to 14 days.
The treatment should continue until the disappearance of clinical symptoms and for another 2 days already in the absence of symptoms. If necessary, the duration of treatment can be increased individually supervised by a doctor.
In chronic recurrent diseases in adults and children, treatment should continue for several courses of 5-10 days with a break in the reception 8 days.
For maintenance therapy dose can be reduced to 500-1000 mg per day (1-2
tablet) for 30 days.
When herpes infection in adults and children is prescribed for 5-10 days prior to the disappearance of symptoms in asymptomatic period – 1 tablet 2 times a day for 30 days to reduce the number of relapses.
When HPV infection adult drug prescribed 2 tablets 3 times a day,
children – 2.1 tablets per 5 kg / body weight per day in 3-4 divided doses for 14-28 days as monotherapy.
When an adult formulation of recurrent genital warts administered 2 tablets 3
times, children – 1.2 tablets per 5 kg / body weight per day in 3-4 divided doses a day or as monotherapy or in combination with surgical treatment for 14-28 days, then with three times repetition rate of said at intervals of 1 month.
Cervical dysplasia associated with human papillomavirus, appoint 2
tablets 3 times a day for 10 days, followed by 2-3 similar course is performed at intervals of
10-14 days.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

TEVA

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