Description
Composition
Active substance:
1 vial contains: interferon gamma – 100,000 IU (5,5 ± 0,5).
Excipients:
Mannitol.
Description:
The drug is a porous mass or a loose white hygroscopic.
Product form:
Lyophilizate for preparation of solution for intranasal administration in vials of 100,000 IU per 1 vial. 1 bottle preparation complete with ampoule of solvent 1 and 5 ml 1-lid polyethylene dropper in a plastic bag or medical pipette in blisters or contoured tape packing.
1 or 5 outline packages with instructions for use are packaged in packs of cardboard.
1 or 5 drug vials supplied respectively with 1 or 5 lids-droppers polyethylene in a plastic bag or medical pipettes and instructions for use are packaged in packs of cardboard.
Contraindications
Hypersensitivity of interferon gamma, or any other component of the preparation. Pregnancy. Children’s age (under 7 years).
Dosage
20,000 IU / ml
Indications
Prevention and treatment (in the complex therapy) flu. Prevention and treatment (in the complex therapy) H5N1 and H1N1 influenza.
pharmachologic effect
Pharmacological group:
Immunostimulatory agent.
Pharmacological properties:
INGARON®- recombinant human interferon gamma consists of 144 amino acid residues (a. A.), And deprived of the first three. about. Cys-Tyr-Cys, replaced at the Met. The molecular weight of 16.9 kDa. Prepared microbiological synthesis in the recombinant strain of Escherichia coli and purified by column chromatography. The specific antiviral activity on cells (human fibroblast) infected with vesicular stomatitis virus is 2 • 107 IU per mg protein.
Gamma Interferon (immune interferon) is a major proinflammatory cytokine producers which in humans are natural killer cells, CD4 Th1 cells and cytotoxic CD8 suppressor cells. Interferon gamma receptors are macrophages, neutrophils, natural killer cells, cytotoxic T lymphocytes. Activates the effector functions of these cells, in particular their mikrobotsidnost, cytotoxicity, production of cytokines and nitroxide superoxide radicals (thereby causing the death of intracellular parasites). Interferon gamma blocking viral DNA replication and RNA synthesis of viral proteins and the assembly of mature virus particles. At the same time causes a cytotoxic effect on the virus-infected cells.
Inhibit B-cell response to IL-4 suppresses the IgE production and expression of CD23-antigen. An inducer of apoptosis of differentiated B cells, which give rise to self-reactive clones. Cancels the suppressive effect of IL-4 on IL-2-dependent proliferation and the generation of lymphokine activated killer cells. Activates the production of proteins of acute inflammation phase, increases the expression of genes C2 and C4 components of the complement system.
Unlike other interferons increases the expression of MHC antigens as the I-st and the II-th classes in different cells, and induces the expression of these molecules even in those cells which do not express them constitutively. Thereby increasing the efficiency of antigen presentation and the ability of their recognition by T lymphocytes.
Interferon gamma blocks the synthesis of beta-TGF, responsible for the development of lung fibrosis and liver.
Conditions of supply of pharmacies
Without recipe.
side effects
Not noted.
Storage conditions
In a dry place, protected from light and the reach of children at a temperature not higher than +25 C.
Dosing and Administration
Intranasally. The contents of the vial were dissolved in 5 ml of water for injection.
At the first sign of flu, SARS 2 drops in each nostril after nasal toilet 5 times a day for 5-7 days.
For the prevention of SARS and influenza in contact with the patient and / or supercooling of 2-3 drops in each nostril every other day for 30 minutes before breakfast for 10 days. If necessary, preventive courses repeated. When only one single contact instillation.
After instillation recommended massage fingers nose wings in minutes for uniform distribution of the drug in the nasal cavity.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist
There are no reviews yet.