Indomethacin suppositories rektal biosynthesis. 100mg 10 pieces


Indomethacin suppositories rektal biosynthesis. 100mg 10 pieces



Active substance:
1 suppository contains: indomethacin – 50 mg or 100 mg.
Colloidal silicon dioxide (Aerosil) solid fat, castor oil, urea (carbamide), propyl parahydroxybenzoate (Nipasol), polysorbate (Tween 80).
Product form:
Suppositories 50 mg or 100 mg.
NSAIDs are contraindicated: in the post-coronary artery bypass surgery; bleeding (including intracranial, gastrointestinal organs of) blood coagulation disorders (including hemophilia, prolonged bleeding, bleeding tendency), impaired hematopoiesis (leucopenia and anemia); Rectal – rectal bleeding; congenital heart defects (coarctation of aorta, pulmonary atresia, tetralogy of Fallot), heart failure; III trimester of pregnancy, lactation, children under 14 years; hypersensitivity to the active substance or auxiliary components; anamnestic data fit bronchial, rhinitis, urticaria, after receiving aspirin or other NSAIDs (complete or incomplete syndrome intolerance of acetylsalicylic acid – rhinosinusitis, urticaria, polyps, nasal mucosa, asthma); ulcerative colitis, erosive and ulcerated gastric mucosal changes or duodenum 12, active gastrointestinal bleeding; inflammatory bowel disease; cirrhosis with portal hypertension, severe liver failure or active liver disease; severe renal impairment (creatinine clearance less than 30 mL / min), progressive renal disease; confirmed by hyperkalemia; diseases of the optic nerve, impaired color vision, hearing loss; asthma, edema; pathology of the vestibular apparatus; deficiency of glucose-6-phosphate dehydrogenase; blood diseases; proctitis, hemorrhoids; hypertension, hemophilia, hypocoagulation.
Ischemic heart disease, cerebrovascular disease, congestive heart failure, dyslipidaemia / hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, creatinine clearance less than 60 mL / min, hyperbilirubinemia, thrombocytopenia, epilepsy, Parkinsonism, depression, hypertension, cirrhosis with portal hypertension , severe somatic diseases, mental disorders.
A history of the development of ulcerative lesions gastrointestinal tract, the presence of infection Helicobacter pylori, children and elderly, long-term use of NSAIDs, frequent alcohol consumption, severe somatic diseases, concomitant therapy with the following drugs: anticoagulants (eg, warfarin), antiplatelet agents (eg, aspirin, clopidogrel ), oral corticosteroids (e.g., prednisone), selective serotonin reuptake inhibitor (such as citalopram, fluoxetine, paroxetine, sertraline).
To reduce the risk of adverse effects on the gastrointestinal tract should use the lowest effective dose of the lowest possible short course.
100 mg
NSAIDs for symptomatic therapy, reducing pain and inflammation at the time of use, does not affect the progression of the disease.
Inflammatory and degenerative diseases of the musculoskeletal system: rheumatoid arthritis, psoriatic, juvenile chronic arthritis, ankylosing spondylitis; rheumatic soft tissue; gouty arthritis.
As an adjuvant in infectious and inflammatory diseases of the upper respiratory tract, adnexitis, prostatitis, cystitis, neuritis, algodismenoree, headache, toothache (in combination therapy).
Interaction with other drugs
Reduces the efficiency of uricosuric drugs, antihypertensives and diuretics (saluretics); enhances the effect of anticoagulants, antiplatelet agents, fibrinolytic agents, the side effects mineralokortikosteroidov, estrogens, other NSAIDs.; enhances hypoglycemic effect of sulfonylurea derivatives, enhances hypoglycemic effect of insulin and of oral hypoglycemic drugs.
Against the background of the use of potassium-sparing diuretics increase the risk of hyperkalemia.
Sharing with paracetamol increases the risk of nephrotoxic effects. Ethanol, colchicine, corticosteroids – increase the risk of gastrointestinal bleeding complications.
Increases concentration of lithium in blood preparations, methotrexate and digoxin. Cyclosporine, gold drugs increase the nephrotoxicity of indomethacin. Cefamandole, ceftazidime, tsefotetan, valproic acid, plikamitsin – increase the risk of hypoprothrombinemia and the risk of bleeding. It enhances the toxic effect of AZT. Myelotoxic drugs increase the expression gematotoksichnosti drug. In infants increases the risk of toxic effects of aminoglycosides.
Symptoms include nausea, vomiting, severe headache, dizziness, memory impairment, disorientation. In severe cases, paresthesia, numbness, convulsions.
Treatment: symptomatic therapy, hemodialysis ineffective.
pharmachologic effect
Pharmacological group:
Nonsteroidal anti-inflammatory drugs.
Indomethacin has anti-inflammatory, analgesic, antipyretic and antiplatelet effect. Inhibits proinflammatory factors reduces platelet aggregation. Inhibiting cyclooxygenase 1 and 2, it gives the arachidonic acid metabolism, reduces the amount of prostaglandins (Pg) both in inflammation and in healthy tissue, inhibits the exudative and the proliferative phases of inflammation. Causes the attenuation or disappearance of pain syndrome, and rheumatoid rheumatic nature (including pain in the joints at rest and during motion, decrease of morning stiffness and joint swelling, increases range of motion; during inflammatory processes occurring after operations and traumas, facilitates fast as a spontaneous pain, and pain during movement, reduces the inflammatory swelling at the wound site).
Absorption – fast. Bioavailability in rectal route of administration – 80-90%. Communication with plasma proteins -. 90%, half-life -4-9 h metabolized mainly in the liver, unchanged output 30% of the formulation. Excreted by the kidneys by 70%, and 30% unchanged, and the gastrointestinal tract – 30%. Not removed by dialysis. It passes into breast milk.
Conditions of supply of pharmacies
On prescription.
side effects
From the digestive system: NSAID gastropathy, abdominal pain, nausea, vomiting, heartburn, anorexia, diarrhea, abnormal liver function (increased bilirubin in the blood, “liver” of transaminases). With prolonged use at high doses – ulceration of the mucous membranes of the gastrointestinal tract.
From the nervous system: headache, dizziness, insomnia, agitation, irritability, fatigue, drowsiness, depression, peripheral neuropathy.
From the senses: hearing loss, tinnitus, taste disturbance, diplopia, blurred vision, corneal opacities, conjunctivitis, photosensitivity.
From the CCC: heart failure, tachyarrhythmia, increased blood pressure.
From the urinary system: renal dysfunction, Proteinuria, hematuria, interstitial nephritis, nephrotic syndrome, necrosis papillae.
On the part of the system of hemostasis: bleeding (gastrointestinal, gingival, uterine, hemorrhoids), thrombocytopenia.
Allergic reactions: skin rash, pruritus, urticaria, angioedema, bronchoconstriction; rarely – Lyell’s syndrome, erythema nodosum, anaphylactic shock.
Laboratory findings: agranulocytosis, leukopenia, hyperglycemia, glycosuria, hyperkalemia.
Other: aplastic anemia, autoimmune hemolytic anemia, aseptic meningitis (usually in patients with autoimmune diseases), increased sweating, edema syndrome, eosinophilia, thrombocytopenic purpura.
Local reactions: burning, itching, heaviness in the anorectal area, worsening of hemorrhoids.
special instructions
During treatment requires monitoring picture peripheral blood and functional state of the liver and kidneys. If necessary, definition of 17-ketosteroids drug should be discontinued 48 hours before the study.
In the period of treatment should refrain from driving motor vehicles and activities potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
In a dry, dark place at a temperature not higher than 25 ° C.
Dosing and Administration
Rectal: after a bowel release, possibly deep in the rectum – 50 mg 1-3 times daily or 100 mg at bedtime, in an attack of gout time of up to 200 mg per day.
The maximum daily dose – 200 mg.
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg


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