Indokollir drops Ch. 0.1% 5 ml-vial cap.

$10.12

Indokollir drops Ch. 0.1% 5 ml-vial cap.

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SKU: 1619713871 Categories: , , Tags: ,

Description

Composition
Active substance:
1 ml contains: 1.0 mg of indomethacin ;.
Excipients:
Thiomersal, arginine, gidroksipropilbetatsiklodekstrin, hydrochloric acid conc., Purified water.
Description:
The clear pale yellow solution.
Product form:
0.1% eye drops.
Primary Packaging: 5 mL vial with a plastic stopper and a screw cap dropper.
Secondary packaging: one vial with instruction for use is enclosed in a cardboard box.
Contraindications
Hypersensitivity to excipients or the active drug; hypersensitivity to aspirin (or other salicylates) and / or other NSAIDs; bronchial asthma history in response to the use of aspirin or other NSAIDs; stomach ulcer; severe hepatic failure; severe renal impairment; pregnancy (starting from the 6th month); breastfeeding; Children under 18 years of age (efficacy and safety data are not available); simultaneous application of indirect anticoagulants, other NSAIDs, including derivatives of salicylic acid (at a dose of 3 g per day and up to adults.); simultaneous application diflunizalom, heparin, lithium preparations, methotrexate in high doses (15 mg / week or more) and ticlopidine.
Carefully. patients predisposed to allergic reactions; while the use of: diuretics, angiotensin converting enzyme (ACE) inhibitors, methotrexate (at doses below 15 mg / week), pentoxifylline; drugs that affect the mucous membrane of the gastrointestinal tract (GIT) (salts, oxides and hydroxides of magnesium, aluminum and calcium), zidovudine, beta-blockers, cyclosporin, desmopressin, thrombolytics. the implantation of intrauterine devices.
Dosage
1 mg / ml
Indications
Inhibition of miosis during surgery on the eyeball;
Prophylaxis of inflammatory complications following cataract surgery and in the anterior chamber of the eye;
Reduction of pain “in the eye” in the postoperative period after photorefractive keratectomy in the first day after surgery.
Interaction with other drugs
Despite the fact that the systemic absorption of indomethacin in the topical application in the form of eye drops is negligible, it is impossible to completely eliminate the risk of drug interactions with other drugs.
Oral anticoagulants, other NSAIDs, diflunisal, heparin.
It is known that use of indomethacin in other dosage forms in conjunction with indirect anticoagulants, other non-steroidal anti-inflammatory drugs in their daily dose of DIG above (including salicylic acid derivatives, e.g., acetylsalicylic acid, and so forth.), Diflunizalom and heparin increases the risk of gastro-intestinal tract ulcers and bleeding, and in combination with diflunizalom until fatal.
In turn, diflunisal may increase the concentration of indomethacin in plasma.
Formulations lithium. Indomethacin can increase the concentration of lithium in the blood to toxic quantities, due to reduced renal excretion of lithium.
Methotrexate (15 mg per week or more). By decreasing the excretion by the kidneys with methotrexate simultaneously with reception indomentatsinom and / or other anti-inflammatory drugs, haematological its effect increases.
Precautions indomethacin with methotrexate is used (in a dose less than 15 mg / week) – requires weekly monitoring of blood parameters during the first weeks of the combined receiving and monitoring of renal function, especially in the elderly.
Ticlopidine. Indomethacin increases the antiplatelet effect of ticlopidine and increases the risk of bleeding.
Indomethacin, when used together with beta-blockers may weaken their effect.
Indomethacin may enhance nephrotoxic effect of cyclosporine, particularly in elderly patients.
NSAIDs can lead to increased anti-diuretic effect of desmopressin.
Caution while indomethacin with diuretics and ACE inhibitors, since dehydration in patients with a risk of acute renal failure (due to a decrease in glomerular filtration of vasodilator prostaglandins by inhibiting after taking NSAIDs) and reduced antihypertensive effect.
In such situations it is necessary to provide the patient with water and monitor renal function at the beginning of treatment.
Combined use of pentoxifylline – an increased risk of bleeding from the gastrointestinal tract (use under medical supervision and monitoring of the duration of bleeding).
Drugs that affect the gastrointestinal mucosa (salts, oxides and hydroxides of magnesium, aluminum and calcium) reduce the absorption of indomethacin from the gastrointestinal tract; recommend separate administration with antacids (if possible interval over 2 hours).
NSAIDs, including indomethacin, may increase the toxic effect of AZT on the reticulocytes with the transition to severe anemia in 8 days after initiation of therapy NSAIDs.
Combined use of thrombolytics – an increased risk of bleeding.
There is an assumption that the application of indomethacin possible risk of rupture of the implantable intrauterine device.
When applied simultaneously with the other drug Indokollir eye drops, including, containing corticosteroids to eliminate the effect of “washout” (loss of concentration), the preparations to be administered at intervals of no less than 15 minutes.
Overdose
There is currently no reported cases of overdose. In the case of a local drug should wash your eyes with warm water overdose. In case of suspicion of the use of oral treatment of symptomatic medication.
pharmachologic effect
Pharmacological group:
Nonsteroidal anti-inflammatory drug (NSAID).
Pharmacodynamics:
Indomethacin – a non-steroidal anti-inflammatory drug (NSAID) having analgesic and anti-inflammatory action. The main mechanism of action of indomethacin is the inhibition of the synthesis of prostaglandins, which play an important role in the pathogenesis of inflammation and pain.
Pharmacokinetics:
With confirmed evidence that the drug penetrates into the anterior chamber of the eye. When a single instillation of the active substance is indomethacin preparation is defined in the moisture in the anterior chamber of the eye for several hours.
Systemic absorption of indomethacin in the topical application of the preparation is negligible.
Pregnancy and breast-feeding
Indokollir drug can be applied during the first five months of pregnancy only if the expected benefit to the mother outweighs the potential risk to the fetus.
Starting from the 6th month of pregnancy use indomethacin eye drops are contraindicated because of the risk of cardiotoxic effects on the fetus (premature closure of the ductus arteriosus and the development of pulmonary arterial hypertension), as well as decreased renal function (up to oligogidroamniona development).
Application Indokollir the drug increases the risk of edema in the mother.
Application Indokollir preparation before delivery can cause prolonged bleeding in the mother and newborn.
Since NSAIDs, including indomethacin, infiltrating breast milk, should discontinue breastfeeding during treatment with Indokollir or exclude its application in breast-feeding period.
Conditions of supply of pharmacies
Prescription.
side effects
The frequency of side effects was evaluated as follows according to the WHO classification: very often (> 1/10), often (> 1/100
special instructions
Preparation Indokollir contains thimerosal, which can cause allergic reactions. If you suspect you are hypersensitive to the drug should be discontinued.
Like other NSAIDs, Indokollir can slow the healing of the cornea.
In the presence of infection or the threat of its development at the same time prescribe adequate antibiotic therapy.
In a joint application with lithium NSAIDs on prescription drugs – you need to adjust the dose of the latter before, during and after NSAID treatment depending on the concentration of lithium in the blood.
NSAIDs can lengthen the time of bleeding in surgical interventions on the eyeball, especially in patients with blood coagulation disorders or receiving anticoagulant. The combined use of medical Indokollir preparation with indirect anticoagulants, heparin and ticlopidine should be under close medical supervision and monitoring of laboratory parameters, including bleeding time.
When combined with methotrexate Indokollir drug at a dose less than 15 mg / week during the first weeks of combined use should control the number of blood cells, as well as to close monitoring of patients with symptoms of renal insufficiency and elderly patients.
The time between taking the drug and any Indokollir antacid should not be less than 2 hours.
When used with diuretics and ACE inhibitors need to monitor renal function and avoid dehydration of the patient.
Before using the product contact lenses must be removed and set back no earlier than 15 minutes after drug application.
Observe interval of 15 minutes while applying Indokollir preparation with other eye drops.
Do not touch the bottle tip to any surface to avoid contamination of the vial and its contents.
The bottle must be closed after each use.
The effect on the ability to operate vehicles, machinery
In some patients, the use of Indokollir drug may be associated with temporary loss of clarity of vision (just after instillation of eye drops), so you should be careful when performing potentially hazardous activities that require high concentration and psychomotor speed reactions (vehicle control, work with moving machinery) .
Storage conditions
In the dark place at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
For topical use in ophthalmology.
Looking up, gently pulled down lower eyelid and the drug was instilled into the conjunctival sac of the affected eye.
To inhibit miosis during surgery on the eyeball – 1 drop 4 times a day before the operation and 1 drop 4 times for 3 hours immediately before surgery.
For the prevention and treatment of inflammatory complications of cataract surgery and in the anterior chamber – 1 drop 4-6 times per day starting 24 h prior to surgery and up to the complete disappearance of the symptoms of inflammation after it.
For pain relief (eye area) in the postoperative period after photorefractive keratectomy – 1 drop 4 times per day during the first few days.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

VALEANT

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