Indinol Forto caps. 200mg 60 pieces

Description

Composition
Active substance:
Indolkarbinol 200mg
Excipients:
Lactose monohydrate (milk sugar) – 0.110 g, modified corn starch – 0.095 g Microcrystalline cellulose – 0.064 g Sodium carboxymethyl starch (sodium starch glycolate) – 0,030g magnesium stearate – 0.001g.
Capsules Composition: hydroxypropyl methylcellulose (hypromellose) – up to 100%, purified water – 6.4%.
Dyes: a capsule body: titanium dioxide, E 171 – 2,113%.
Dyes: a capsule cap: sunset yellow colorant E 110 – 0.136%, titanium dioxide, E 171 – 2,437%.
Description:
Cellulose capsule №0 with the body in white and orange cover.
The contents of capsules – powder from white to light-yellow or light-brown color, with a slight specific odor.
Product form:
Upakovka- 60 capsules of 200 mg.
Contraindications
Increased sensitivity to the drug;
Hereditary galactose intolerance, lactase deficiency or glucose-galactose malabsorption;
During pregnancy and breastfeeding;
Children and adolescents under 18 years of age
Dosage
200 mg
Indications
Cyclical mastalgia, including the background of benign hyperplasia of the breast.
Interaction with other drugs
Given the impact indolkarbinola the activity of cytochrome P450 isoenzymes, caution should be exercised when used together with drugs, metabolism involving isozymes of cytochrome P450 (oral anticoagulants, corticosteroids, oral hypoglycemic agents, antiarrhythmics, antiepileptics, digitalis preparations, preparations sex hormones), m. to. It may require adjustment of the dose.
Overdose
Nausea, vomiting, diarrhea.
If you suspect an overdose, symptomatic therapy is recommended.
pharmachologic effect
Pharmacological group:
ekstrogenovyh selective receptor modulator.
Pharmacological properties:
Indinol Forto is universal corrector pathological processes in hyperplastic breast tissue. The basis of the therapeutic effect Indinol Forto is his antiestragennoe and antiproliferative effects. Indinola® Forto main feature is its ability to cause the selective destruction of cells with abnormally high proliferative activity in the breast and other organs of estrogen. The drug modulates the cytochrome system in a way that the resulting cytochrome P450 isoform – SYR1A1 hydroxylated oestrogens in the 2-position, to form a 2-hydroxyestrone (2-ONE1). The resulting metabolite is an antagonist of estrogen receptor and blocks its activation by the estrogen, as well as their metabolites dangerous, particularly 16alfa-hydroxyestrone (16alfa-ONE1) which share among metabolites decreases. So suppressed the induction of estrogen-dependent genes and the cell stops receiving excessive estrogen dependent stimulation. The drug also blocks other signaling mechanisms (cytokine) stimulating abnormal cell growth in estrogen-dependent tissues, by suppressing signaling pathways of the respective receptors.
A course of application of the drug helps to reduce the intensity and disappearance of pain in the breast in cyclical mastalgia (mastodynia).
No increase in body weight. It refers to substantially non-toxic drugs (LD50> 5 g / kg).
Pregnancy and breast-feeding
Protivopakazano during pregnancy and lactation.
Conditions of supply of pharmacies
Drug prescription.
side effects
Violations by the genitals and breast: irregular menstrual cycle in a lengthening or shortening.
Disorders of the gastrointestinal tract: epigastric pain.
Laboratory and instrumental data: increasing the concentration of thyroid-stimulating and follicle-stimulating hormone, prolactin and estradiol decreased creatinine concentration, eosinophilia.
Violation of the obmna substances and power: weight loss.
If any of these instructions side effects are compounded, or found any other side effects not mentioned in the instructions, tell your doctor.
special instructions
Effects on ability to drive vehicles and management mechanisms
Based on the characteristics and pharmacodynamic profile of adverse effects, it is unlikely that IndinolV® Forto affects the ability to drive trucks soedstvami and operate machinery.
Storage conditions
The preparation should be stored in a dry place, protected from light and the reach of children at a temperature not higher than 25 ° C.
Dosing and Administration
Inside, 2 times / day 200 mg. The daily dose is 400 mg. Capsules are taken before a meal. Duration of treatment 6 months.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist