Hydrocortisone ointment for naruzhn.prim-I 1% 10g tuba Nizhpharm

Description

Composition
Active substance:
1 g of ointment contains 10.0 mg of hydrocortisone acetate.
Excipients:
Petrolatum – 450.0 mg, lanolin – 100.0 mg, pentaerythrityl dioleate (Pentol) – 50.0 mg, stearic acid 95 – 30.0 mg methyl parahydroxybenzoate – 0.8 mg propyl parahydroxybenzoate – 0.2 mg Water – up to 1 year
Description:
Ointment from white to a yellowish tinge to light yellow in color.
Product form:
Ointment for external application of 1% on 10 g aluminum tubes. Each tube together with instructions for medical use of the formulation was put in a pile of cardboard.
Contraindications
Hypersensitivity to hydrocortisone, and any of the excipients of the formulation; wound, ulcerative skin lesions, bacterial, viral and fungal infections of the skin, tuberculous and syphilitic lesions of the skin; rosacea, acne vulgaris, perioral dermatitis; skin tumors; pregnancy, breastfeeding (because of the lack of clinical application of security data); Children under 2 years old.
Carefully
Diabetes, tuberculosis (systemic disease).
Dosage
10 mg / g
Indications
Inflammatory and allergic skin diseases nemikrobnoy etiology: eczema, atopic and contact dermatitis, atopic dermatitis, psoriasis.
Interaction with other drugs
With prolonged use, due to possible resorption into the systemic circulation, hydrocortisone may reduce the effectiveness of insulin, oral hypoglycemic, antihypertensive drugs, anticoagulants, salicylates and praziquantel concentration in blood plasma.
The risk of side effects of hydrocortisone increases:
androgens, estrogens, oral contraceptives, anabolic steroids (hirsutism, acne); antipsychotic drugs, carbutamide, azathioprine (cataract); holinoblokatory, antihistamine drugs, tricyclic antidepressants, nitrates (glaucoma); diuretics (hypokalemia); non-steroidal anti-inflammatory drugs (increased risk of ulceration in the gastrointestinal tract); paracetamol (hepatotoxicity).
When used with cardiac glycosides may develop digitalis intoxication.
Concomitant use of drugs with lead and silver results in mutual inactivation.
When combined with the use of amphotericin B may develop dilatation of myocardial damage and heart failure.
Barbiturates, antiepileptics and antihistamines reduce the efficiency of hydrocortisone.
Overdose
Symptoms. Acute overdose is unlikely. With long-term use of the drug in high doses may cause symptoms of Cushing (hyperglycemia, glycosuria, reversible depression of adrenocortical function, Cushing’s syndrome).
Treatment is symptomatic; It recommended a gradual withdrawal of the drug.
pharmachologic effect
Pharmacological group:
Glucocorticosteroids for local use.
Pharmacological properties:
Hydrocortisone is a synthetic glucocorticosteroids for topical anti-inflammatory, decongestant, an antipruritic effect. Inhibits the release of cytokines (interleukins and interferon) from lymphocytes and macrophages, eosinophils inhibits the release of inflammatory mediators, reduces arachidonic acid metabolism and prostaglandin synthesis. Stimulating steroid receptors induces the formation of lipocortin. Reduces inflammatory cell infiltrates, reduces migration of leukocytes and lymphocytes in the area of ​​inflammation. Topical administration of the drug at the recommended doses, does not cause adverse systemic effects.
Pharmacokinetics:
After the application is stored in the epidermis (mainly the granular layer). It metabolized directly in the epidermis, and further in the liver. Excreted by the kidneys and the bile.
Conditions of supply of pharmacies
Without recipe.
side effects
Congestion, swelling and itching at the site of application of the ointment. With prolonged use may develop as secondary infections of the skin lesions, atrophic changes in it, hypertrichosis. With prolonged use of ointment or use of occlusive dressings, especially on large areas of lesions may develop Cushing, as a manifestation of resorptive action of hydrocortisone acetate.
special instructions
In the case of the drug in children in the area of ​​the face or under the duration of the treatment of occlusive dressings should be reduced.
In childhood, the suppression of adrenocortical function may develop more quickly. Furthermore, there may be a decrease of excretion of growth hormone. In applying the drug for a long time is required to observe the body weight, height, level of plasma cortisol. Children under 12 years of drug administered only under medical supervision.
Avoid contact with the eyes ointment.
If, after 7 days of treatment no improvement or deterioration is observed and in the event of a resumption of symptoms a few days after discontinuation of the drug, use of the drug should be discontinued and consult a doctor.
Prolonged treatment and / or applied to the large surface of the diet is recommended to assign sodium restriction and increased content of K +; be administered in a sufficient amount of protein.
It is necessary to monitor blood pressure, blood glucose content, blood clotting, diuresis, patient body weight, plasma levels of cortisol.
For the prevention of infectious skin lesions drug recommended given in combination with antibacterial and antifungal agents.
There is no data about the negative effects of the drug hydrocortisone ointment for external application of 1% on the ability to drive vehicles and to perform other potentially dangerous activities.
Storage conditions
At a temperature of not higher than 20 ° C.
Keep out of the reach of children.
Dosing and Administration
Outwardly. The ointment is applied a thin layer to the affected areas of skin 2-3 times a day.
The duration of treatment depends on the nature of the disease and the effectiveness of therapy, accounting, usually 6-14 days; when the thrust course of the disease may be extended to 20 days. In limited foci to enhance the effect can be used with occlusive dressings. In applying the ointment in children aged 2 years and older should limit the total duration of treatment and exclude activities leading to increased bone resorption (sucking) of steroid (warming, fixing and occlusive dressings).
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist