Gyno-Pevara suppositories vaginas. 150mg 3 pcs

Description

Composition
Active substance:
econazole nitrate – 150 mg
Excipients:
tallow (type A and type B).
Description:
Suppositories are white to off-white, torpedo-shaped.
Product form:
3 suppository in a blister made of PVC, and low density polyethylene. 1 is placed in a blister pack with a cardboard enclosed instructions for use.
Contraindications
– hypersensitivity to any component of the drug.
– Children under the age of 16 C care
Data on the use Gyno-Pevara in the elderly (over 65 years) are not sufficient.
Dosage
150 mg
Indications
Gino-Pevaril® indicated for the treatment of vulvovaginal mycoses.
Interaction with other drugs
Econazole is an inhibitor of isozyme CYP3A4 / 2C29. However, taking into account that the drug is poorly absorbed into the systemic circulation, the occurrence of clinically relevant interactions are unlikely, although there has been with oral anticoagulants.
Patients taking oral anticoagulants, such as warfarin and acenocoumarol, must be careful and monitor the blood clotting parameters.
Overdose
Until now, data on overdose are available. If you accidentally taking the drug nausea may occur inside, vomiting and diarrhea. In such cases, symptomatic therapy should be performed if necessary.
pharmachologic effect
Pharmacological group:
antifungal agent
Pharmacodynamics:
Econazole nitrate has a broad spectrum of activity and is active against dermatophytes,
yeasts and molds. It also has clinically significant activity against gram-positive bacteria.
Econazole nitrate damages cell membranes, resulting in increased fungal cell permeability. Target for econazole are acyl groups of unsaturated fatty acids that make up the membrane phospholipids.
Pharmacokinetics:
Econazole nitrate poorly absorbed after administration into the vagina absorbed about 5%
of the administered dose. Maximum concentrations of econazole and / or its metabolites in the blood are observed for 1-2 days after application, reaching 15 ng / mL for a dosage suppository
50 mg and 65 ng / mL for a dosage suppositories of 150 mg.
Econazole and / or its metabolites bind strongly to serum proteins (98%). Econazole exposed active metabolism by oxidation, deamination, and O-dealkylation,
its metabolites are excreted by the kidneys and through the intestines.
Pregnancy and breast-feeding
Pregnancy
Gyno-Pevaril® able to be absorbed from the vagina into the systemic circulation, so it should not be used during the first trimester of pregnancy, unless the doctor determines that treatment with this drug is important for the patient’s health. During the second and third trimesters of pregnancy Gyno-Pevaril® can be used, if the potential benefit for women exceeds the potential risk to the fetus.
Lactation
It is not known whether econazole nitrate in breast milk. During lactation the drug should be used with caution.
Conditions of supply of pharmacies
On prescription
side effects
In the application of Guinot-Pevara local irritation may occur, a burning sensation, itching,
erythema, rash. There are isolated cases of allergic reactions such as urticaria and angioedema.
Side effects of the drug are organized by bodies and the frequency of occurrence using the following classification: very common (> 1/10), common (> 1/100,
special instructions
The drug is intended for intravaginal use. Not intended for ingestion.
In case of accidental contact with eyes, the drug should be washed immediately with clean water or saline solution and, if necessary, seek medical attention.
The simultaneous use of latex condoms and vaginal diaphragms or anti-infective drugs may decrease the effectiveness of latex barrier contraceptives. For this reason, Gyno-Pevaril® not recommended for use in conjunction with a diaphragm or condom. Patients using spermicidal contraceptives should consult with your doctor, because medications taken for intravaginal administration may inactivate the spermicidal contraceptive.
Gino-Pevaril® not be used in combination with other drugs for the treatment of genital diseases appointed inwardly or outwardly.
In the case of pronounced irritation or hypersensitivity treatment
Gyno-Pevarilom must stop.
Patients who are sensitive to imidazoles possible hypersensitivity and econazole nitrate.
The effect on the ability of control of vehicles and mechanisms
It does not affect the ability to drive and use machines.
Storage conditions
Store at a temperature of from 15 to 30 degrees.
Keep out of the reach of children
Dosing and Administration
Vaginally.
The vaginal suppository is administered deeply in the vagina, in the supine position immediately before bedtime for 3 days. In case of recurrence or positive culture results after 1 week after treatment by a second course of treatment.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist