Griseofulvin 125mg tab 20 pc

Description

Composition
Active substance:
1 tablet contains: griseofulvin (based on active substance) – 125 mg.
Excipients:
Lactose monohydrate (milk sugar), calcium stearate, povidone (polyvinylpyrrolidone low molecular Medical 12600 ± 2700), potato starch.
Product form:
Tablets.
Contraindications
Hypersensitivity to griseofulvin or to any component of the preparation, porphyria, systemic lupus erythematosus, lupus syndrome, systemic blood disease, leukopenia, organic liver and kidney disease, liver failure, malignancy, pregnancy, lactation, children under 3 years .
Dosage
125 mg
Indications
mycosis of the skin, hair and nails (microsporia trihofitia, crusted ringworm, onychomycosis, jock itch).
Interaction with other drugs
Reduces activity estrogensoderjath oral contraceptives, anticoagulants type indirect action owing to the induction of microsomal liver enzymes.
Barbiturates and primidone reduce antifungal activity.
Overdose
In case of overdose, it is recommended symptomatic therapy and treatment to maintain vital organs and systems.
pharmachologic effect
Pharmacological group:
Antifungal agents.
Pharmacodynamics:
Antifungal antibiotic is effective against fungi of the genus Trichophyton, Microsporum, Epydermophyton Achorionum; disturbs the structure of the mitotic spindle and cell wall synthesis from chitin-containing fungi, fungal cells inhibits division in the metaphase and protein synthesis due to disturbances due to messenger ribonucleic acid. It accumulates in the cells of the skin, hair and nails, which are the precursors of keratin, making keratin resistant to fungal infestation. As the separation of the infected keratin is replaced him healthy tissue.
Pharmacokinetics:
Absorption – High: microcrystalline form 25 – 70%, ultramikrokristallicheskaya form – almost 100%. Eating fat increases the absorption. Time to peak drug concentrations in plasma after ingestion – 4 – 5 h, the maximum drug concentration in plasma – 0.5 – 5 mg / l. Relationship to plasma proteins – 80%. Selectively accumulates in the horny layer of the skin and its appendages, as well as in liver, adipose tissue, skeletal muscle. A small number distributed in body fluids and tissues. It crosses the placenta.
It is metabolized in the liver to inactive metabolites (6-glucuronide and metilgrizeofulvina derivative). The half-life of the drug – 24 hours. Excreted by the kidneys (including 1% – unchanged), and through the intestine (36% unchanged).
Pregnancy and breast-feeding
The drug is contraindicated in pregnancy, as griseofulvin crosses the placenta. The period of treatment should stop breastfeeding.
Conditions of supply of pharmacies
On prescription.
side effects
From the nervous system: headache, dizziness, weakness, fatigue, insomnia, peripheral neuropathy, impaired motor coordination, disorientation, paresthesias of extremities, confusion.
From the digestive system: nausea, vomiting, diarrhea, gastralgia, oral candidiasis, hepatitis.
From the side of hematopoiesis: granulocytopenia, agranulocytosis, leukopenia.
Allergic reactions: hives, skin rash, pruritus, angioedema, photosensitivity, lupus syndrome, erythema multiforme, toxic epidermal necrolysis (Lyell’s syndrome).
In common rashes desensibiliziruyuschuyu therapy. If the rash will increase griseofulvin should be discontinued for 3 – 4 days. After the disappearance of rashes antibiotic prescribed again, but start with 1/2 tablet per day and then gradually increase the dose to the original for 3 – 4 days.
special instructions
Due to the negative impact on reproductive function (both men and women) need to use effective non-hormonal methods of contraception.
systemic Griseofulvin not used for the treatment of mild infections, for which purpose only sufficient antifungal agents for external application.
Effects on ability to drive vehicles, machinery.
It should take into account the potential for the development of side effects such as dizziness, drowsiness, impaired coordination of movements, disorientation, confusion. When the described adverse events should refrain from carrying out these activities.
Storage conditions
In a dry place at a temperature not higher than 20 ° C.
Dosing and Administration
Inside, during or after a meal, in one or more steps. Adults – a daily dose of 500 mg. In severe fungal infections, increase the dose. Babies – a daily dose of 10 mg / kg.
The duration of treatment for serious fungal infections – up to 12 months. The course of treatment in the defeat of the body’s skin – 2-4 weeks, the scalp – 4-6 weeks, stop – 4-8 weeks, the fingers – no less than 4 months, the toes – at least 6 months. The highest daily dose – 1 year
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist