Glutargin alkoklin Table 1d 2 pcs

Description

Composition
Active substance:
arginine glutamate (in terms of 100% substance) 1.0 g
Excipients:
microcrystalline cellulose (MCC 101), crospovidone, calcium stearate
Description:
Tablets white, biconvex, oblong shape with the mark.
Product form:
Tablets 1 till 1 tablets in blisters. 1 blisters with 10 tablets together with instructions for medical use in a stack of cardboard.
Contraindications
– Hypersensitivity to the drug – Children under 18 years – during pregnancy and lactation
Precautions – fever – irritability – severe disorders filtration (azotovydelitelnoy) renal function (creatinine clearance less than 30 mL / min)
Dosage
750 mg
Indications
Prevention of intoxication and hepatotoxic effects of alcohol. Treatment of acute alcohol intoxication mild to moderate severity, as well as in the adjuvant therapy postintoksikatsionnyh disorders after acute alcohol poisoning and severe.
Interaction with other drugs
Caution must be exercised when combined preparation Glutargin with the following drugs:
aminophylline to increase the blood concentration of endogenous insulin influenced Glu-targina alkoklina. Glutargin alkoklin can enhance the effect of antiplatelet agents (dipyridamole et al.), Prevents and attenuates the neurotoxic effects that can occur with isoniazid therapy attenuates effect of vinblastine.
Overdose
Symptoms include nausea, vomiting, pain in the chest, feeling of discomfort in the epigastrium, insomnia, transient short-term reduction in blood pressure, heart block, and allergic reactions.
Treatment: symptomatic, if necessary intake of antihistamines, in severe cases – intravenous corticosteroids.
pharmachologic effect
Pharmacological group:
Hepatoprotective agent.
Pharmacodynamics:
Glutargin alkoklin compound is arginine and glutamic acid, which play an important role in the biochemical processes of neutralization and excretion of a highly toxic metabolite of nitrogenous exchange of substances – ammonia. Has a hepatoprotective effect, having antioxidant, antigipoksicheskoy and membrane stabilizing activity positively affects the processes of energy supply in the hepatocytes.
When alcohol intoxication Glutargin alkoklin stimulates alcohol utilization in hepatic monooxygenase system, prevents depression of a key enzyme in the ethanol utilization – alcohol; It accelerates the inactivation and excretion of toxic products of metabolism of ethanol as a result of increasing the formation and oxidation of succinic acid; reduces the inhibitory effects of alcohol on central nervous system due to excitatory neurotransmitter properties glutamic acid.
Glutargin alkoklin has no embryotoxic, gonadotoxic and mutagenic effects, does not cause allergic, immunotoxic reactions.
Pharmacokinetics:
I have not been studied
Conditions of supply of pharmacies
On prescription.
side effects
Occasionally there may be a feeling mild discomfort in the epigastric region and nausea immediately after treatment, who are alone.
special instructions
When administered to patients with dysfunction of the endocrine glands should be noted that the drug may slightly increase the secretion of growth hormone and insulin, which does not require correction of drug therapy in patients with diabetes and / or acromegaly.
Effect of the drug on the vehicles ability to drive
The drug does not affect the ability to drive a vehicle.
Storage conditions
Store in a cool dry place at a temperature no higher than 25 degrees.
Keep out of the reach of children.
Dosing and Administration
The drug is prescribed for adults inside, regardless of the meal.
For the prevention of intoxication and hepatotoxicity of alcohol administered 2 tablets (2 g) for 1-2 hours before drinking alcohol or 1 tablet (1 g) for 1 hour before drinking alcohol and 1 tablet (1 g) for 0.5 hours after alcohol intake.
For the treatment of acute alcohol intoxication, mild and severe prescribed 1 tablet (1 g), 4 times a day at intervals of 1-2.5 hours, the next 2-3 days – 1 tablet 2 times per day. When alcohol severe poisoning, after a course of intravenous drug use Glutargin, prescribed 1 tablet (1 g) Glutargin alkoklina 2 times a day for 20 days in the complex therapy.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist