Ghayr tab n / about 10 pcs 500mg

$9.39

Ghayr tab n / about 10 pcs 500mg

Quantity:

Description

Composition
Active substance:
1 tablet contains: ornidazole 500 mg.
Excipients:
Microcrystalline cellulose, lactose, colloidal silicon dioxide, povidone (K-30), sodium lauryl sulfate, talc, magnesium stearate, sodium croscarmellose.
shell composition: Opadry II (85G51314) (hypromellose (HPMC 2910), titanium dioxide, macrogol-400 aluminum lake dye quinoline yellow aluminum lake dye Brilliant Blue).
Description:
Oblong biconvex tablets green, film-coated, scored on one side and smooth on the other. At the turn of two layers are visible: green shell and tablet mass almost white.
Product form:
Tablets, film-coated, 500 mg. 3 or 10 tablets in a blister made of PVC / aluminum foil.
1, 4, 5, 7 or 10 blisters 3 tablets in a cardboard box, together with instructions for medical use.
1 or 2 blisters 10 tablets in a cardboard box, together with instructions for medical use.
Contraindications
Hypersensitivity to ornidazole and other nitroimidazole derivatives, as well as other components of the preparation.
Leukopenia (including in history).
Organic lesions of the central nervous system (including epilepsy).
Pregnancy (I term), lactation.
Children under 3 years of age (for a given dosage form).
Rare hereditary disorders such as galactose intolerance, lactase deficiency or glucose-galactose malabsorption.
CAREFULLY.
Pregnancy (II-III trimesters), renal / hepatic failure.
Dosage
500 mg
Indications
trichomoniasis;
All forms of amebiasis (intestinal and extraintestinal disorders localization, including amebic liver abscess, amoebic dysentery and asymptomatic amoebiasis);
giardiasis;
Anaerobic bacterial infections (abdominal and gynecological infections caused by Bacteroides spp., Clostridium spp., Eubacterium spp., Peptococcus spp.,
Peptostreptococcus spp. and other anaerobes sensitive ornidazole.
Treatment of infection of Helicobacter pylori in peptic ulcer disease 12 duodenal ulcer or stomach in combination with bismuth and antibiotics.
Prophylactic before surgery on the gastrointestinal tract and reproductive organs.
Interaction with other drugs
It enhances the effect of coumarin anticoagulants, prolongs the muscle relaxant action of vecuronium bromide. Compatible with ethanol (not inhibit acetaldehyde dehydrogenase) unlike other imidazole derivatives (metronidazole).
Overdose
High doses can cause amplification of side effects, mainly nausea, vomiting, and vertigo; In more severe cases, there may be a ataxia, paresthesias, and seizures, depression. In the case of poisoning apply symptomatic and supportive treatment.
There is no specific antidote.
pharmachologic effect
Pharmacological group:
Protivoprotozoynoe means.
Pharmacodynamics:
Antiprotozoal and antimicrobial agent, 5-nitroimidazole derivative.
The mechanism of action is in the biochemical reduction of 5-nitro ornidazole intracellular transport proteins of anaerobic microorganisms and protozoa. The recovered 5-nitro ornidazole interacts with DNA microbial cells by inhibiting synthesis of nucleic acids, which leads to the death of the bacteria.
It is active against Trichomonas vaginalis, Gardnerella vaginalis, Giardia intestinal is,
Entamoeba histolytica, Lamblia spp., As well as obligate anaerobes Bacteroides spp. (Including
Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron,
Bacteroides vulgatus), Fusobacterium spp., Veillonela spp., Prevotella (P. bivia, P. buccae,
P. disiens), and some gram-positive microorganisms (Eubacterium spp., Clostridium).
By ornidazol not sensitive aerobic microorganisms.
Pharmacokinetics:
Absorption from the gastrointestinal tract – high. Bioavailability – 90%.
The maximum plasma concentration of about 30 mcg / ml is reached within 2 hours after administration of a single dose of 1.5 grams, which is reduced to 9 g / ml after 24 h and 2.5 g / ml after 48 hours.
The half-life (T1 / 2) – 12-14 hours The connection to plasma proteins -. 15% or more. It penetrates the blood-brain barrier.
Displayed as metabolites kidney (60-70%) and in the intestine (20-25%), about 5% of the dose is excreted unchanged. 85% of a single dose excreted within 5 days.
Conditions of supply of pharmacies
On prescription.
side effects
CNS: headache, dizziness, tremor, muscle rigidity, incoordination, convulsions, sensory or mixed peripheral neuropathy, vertigo, sleep disturbance, fatigue, anxiety, irritability, temporary loss of consciousness.
On the part of the digestive tract: epigastric pain, nausea, vomiting, diarrhea, constipation, intestinal colic, loss of appetite, there have been cases of perversion in taste, changes in liver function tests.
On the part of the hematopoietic system: leukopenia.
On the part of the musculoskeletal system: arthralgia.
Allergic reactions: skin rash, pruritus, urticaria.
special instructions
Patients with severe hepatic insufficiency ornidazole should be used with caution, as a result of slow metabolism concentration ornidazole and its metabolites in plasma increases.
Due to the slow excretion need to be careful when choosing the dose of ornidazole in patients with renal insufficiency. In such patients, the dose should be reduced by half.
Ornidazole should be used with extreme caution in patients with bone marrow depression and central nervous system, as well as in elderly patients. The emergence of ataxia, dizziness and any other worsening of neurological status of patients required discontinuation of treatment.
When long-term therapy (over 10 days) should be monitored picture peripheral blood and liver function.
When leukopenia possibility of further treatment depends on the risk of infection.
In the treatment of Trichomonas vaginitis in women and urethritis in men Trichomonas should refrain from sexual activity. Required simultaneous treatment of sexual partners. After treatment of trichomoniasis should hold control samples for three consecutive cycles before and after menstruation.
After treatment of giardiasis, if symptoms persist after 3-4 weeks is necessary to conduct the analysis of stool 3 at intervals of a few days (some successfully treated cases of lactose intolerance, caused by the invasion, may persist for several weeks or months, reminding giardiasis symptoms).
Effects on ability to drive a vehicle,
MECHANISMS
During the period of treatment is not recommended to drive and engage in other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
Store at a temperature not higher than 30 ° C, in a dry and dark place.
Keep out of the reach of children.
Dosing and Administration
Ornidazole taken orally after meal with a little water.
trichomoniasis
Adults:
1 tablet 2 times a day (morning and evening) for 5 days.
Women must additionally assign ornidazole in the form of vaginal tablets.
you can repeat the treatment if necessary. should make a break between courses of 3-4 weeks to conduct repeated control laboratory tests.
An alternative scheme is to assign therapy to 2 g once the patient and his sex partner.
Treatment is carried out simultaneously in both sexual partners.
Children:
The daily dose for children is 25 mg / kg body weight administered in one portion.
amoebiasis
Possible regimens:
Adults and children weighing more than 35 kg. a) The daily dose of 3 tablets at one time in the evening, with body weight more than 60 kg – 4 tablets (2 tablets morning and evening), the duration of treatment 3 days. b) the daily dosage of 2 tablets (1 tablet in the morning and evening), duration of treatment is 5-10 days.
Children weighing up to 35 kg. a) The daily dose of 40 mg / kg body weight at one time, the duration of treatment 3 days. b) the daily dose of 25 mg / kg body weight at one time, the duration of treatment is 5-10 days.
Adults:
In asymptomatic amoebiasis 500 mg (1 tablet) 2-3 times a day for 5-7 days.
In chronic amebiasis 500 mg (1 tablet) 3 times a day for 5-10 days.
In acute amebic dysentery 1.5 g (3 tablets) 1 time per day.
When liver abscess maximum daily dose of 2.5 g to 1 or 2-3 hours, 3-5 days, in combination with antibiotics (tetracyclines), and other treatments.
giardiasis
Adults and children weighing more than 35 kg: 3 tablets once in the evening.
Children weighing less than 35 kg: 40 mg / kg once a day.
The duration of treatment is 1-2 days.
Infections caused by anaerobic bacteria
Adults:
500 mg (1-2 tablets) 3 times a day, during or after meals.
Ornidazole can be used as monotherapy or in combination with other antibacterial agents.
Children:
The daily dose for children is 10 mg / kg body weight, and is assigned 2 times per day.
The average treatment period should not exceed 7 days.
Prophylaxis of infections caused by anaerobic bacteria (before surgery to the abdomen, in gynecology and obstetrics)
First, 1 g (2 500 mg tablets) in a single dose, followed by 1 tablet 500 mg 2 times a day for 3-5 days.
Helicobacter pylori eradication
500 mg 3 times a day for 7 days (in a combination therapy, for instance, with amoxicillin 2.25 g / d.).
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

CORAL MED

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