Geptral tab n / an kish.rastv. 500mg 20 pieces

Description

Contraindications
Genetic defects affecting the methionine cycle and / or causing homocystinuria, and / or hyperhomocysteinemia (e.g., deficit cystathionine beta-synthase, impaired metabolism cyanocobalamin); hypersensitivity to any component of the drug; age 18 years (experience of medical use in children is limited).
* Caution: bipolar disorder; pregnancy (I term) and during breast-feeding; simultaneous with selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (such as clomipramine) as well as herbal medicines and formulations containing tryptophan; elderly age; renal insufficiency.
* Full details are provided in the instructions for medical use.
Indications
Intrahepatic cholestasis when pretsirroticheskih and cirrhotic conditions that may occur in the following disease: fatty liver, chronic hepatitis, toxic liver lesions of different etiology, including alcoholic, viral, drug (antibiotics, antineoplastic, antitubercular, and antiviral drugs, tricyclic antidepressants, oral contraceptives) , acalculous chronic cholecystitis, cholangitis, cirrhosis, encephalopathy, including associated with liver disease (alcoholic and al.); intrahepatic cholestasis in pregnant women; symptoms of depression.
* Full details are provided in the instructions for medical use.
Interaction with other drugs
There are reports of serotonin syndrome, the excess in patients taking ademetionine and clomipramine.
* Full details are provided in the instructions for medical use.
Overdose
In case of overdose, it is recommended for the patient observation and symptomatic therapy.
* Full details are provided in the instructions for medical use.
pharmachologic effect
Pharmacological group:
* Full details are provided in the instructions for medical use.
Pharmacological properties:
* Full details are provided in the instructions for medical use.
Pharmacodynamics:
* Full details are provided in the instructions for medical use.
Pharmacokinetics:
* Full details are provided in the instructions for medical use.
Pregnancy and breast-feeding
In clinical studies it has been shown that the use of ademetionina in the III trimester of pregnancy did not cause any adverse effects. Use of the drug in pregnant Geptral® in I and II trimesters of pregnancy, and lactation is possible only if the potential benefit to the mother outweighs the potential risk to the fetus or child.
* Full details are provided in the instructions for medical use.
Conditions of supply of pharmacies
Prescription.
side effects
Insomnia; anxiety; headache; abdominal pain; nausea; diarrhea; itchy skin.
* Full details are provided in the instructions for medical use.
special instructions
Given the invigorating effect of the drug is not recommended to take the drug at bedtime. In applying the drug Geptral® patients with cirrhosis amid hyperasotemia systematic control of nitrogen content in the blood. During long-term therapy is necessary to determine the content of urea and creatinine in serum. Not recommended for use in patients ademetionine c bipolar disorder. There are reports of depression going into hypomania or mania in patients taking ademetionine.
Effects on ability to drive vehicles, mechanisms: in some patients when taking the drug Geptral® can be dizziness. Not recommended to transport and work with mechanisms during treatment Geptral® as long as patients are confident that the therapy does not affect the ability to engage in this type of activity.
* Full details are provided in the instructions for medical use.
Storage conditions
Store at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Inside. Tablets should be taken whole, without chewing, in between meals. Tablets Geptral® preparation must be removed from the blister immediately before ingestion. If the pills have a color other than white to light yellow in color (due to leakage of aluminum foil), the drug is not recommended for use Geptral®. Initial therapy: The recommended dose is 10-25 mg / kg / day orally.
Depression: The usual initial dose is 500-800 mg / day, the total daily dose should not exceed 1600 mg.
Intrahepatic cholestasis: the usual initial dose is 500-800 mg / day, the total daily dose should not exceed 1600 mg.
Maintenance Therapy: 500 or 800-1600 mg / day.
The duration of therapy is determined by the doctor. Geptral® drug therapy may be initiated with the intramuscular or intravenous administration, followed by applying a preparation Geptral® in the form of tablets or simultaneously with drug application Geptral® in tablet form.
* Full details are provided in the instructions for medical use.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist