Gepazolon rectal suppositories 10 pc

$6.60

Gepazolon rectal suppositories 10 pc

Quantity:

Description

Composition
Active substance:
1 suppository contains: Sodium heparin 120 IU, prednisolone 1,7 mg lidocaine hydrochloride 10 mg ;.
Excipients:
Witepsol H 15 – sufficient quantity to obtain a suppository weight 1.0 g
Description:
Suppositories are white or white with yellowish or Valium a color shade, torpedo-shaped.
Product form:
Rectal suppositories. 5 pieces in blisters made of PVC film. Two contour package together with instructions for use in paper cartons.
Contraindications
Hypersensitivity to the drug.
Viral, fungal, tuberculosis and other infectious processes anorectal disorders of the coagulation system with a predisposition to bleeding.
Pregnancy and lactation.
Children up to age 12 years.
Indications
External and internal hemorrhoids, including acute, fistulas, eczema, itching in the anus, caused by inflammation, anal fissures.
pharmachologic effect
Pharmacological group:
Hemorrhoids treatment for.
Pharmacodynamics:
. Pharmacological action determined by the properties of components included in the formulation.
Heparin prevents the formation of blood clots and prevents blood coagulation in hemorrhoids, has anti-edematous action, promotes the regeneration of connective tissue, accelerates healing and reduces the number of relapses. Heparin inhibits the reaction, causing the blood coagulation and fibrin clot forming. Heparin in this dosage in combination with antithrombin III plasma inhibits thrombosis by deactivating factor Xa as well as by inhibiting the conversion of prothrombin to thrombin. Heparin inhibits the formation of a stable fibrin clot by inhibiting the activation of fibrinstabiliziruyuschego factor. Heparin also exhibits anti-inflammatory effects, affecting the vascular endothelium prevents edema.
Prednisolone belongs to a group of synthetic glucocorticosteroids average duration, reduces the formation, release and activity of inflammation mediators (histamine, kinin, prostaglandin, lysosomal enzymes). Inhibits cell migration to the site of inflammation; reduces vasodilation and increased vascular permeability in inflammation. Reduces exudation due to vasoconstrictor effect. Inhibits the action of the macrophages of the target cells, cytokines are involved in the development of allergic reactions. Prevents access of sensitized T-lymphocytes and macrophages to target cells. Anti-inflammatory, protivoekssudativnoe and antiallergic action, reduces inflammation and associated subjective sensations (itching, burning, pain, feeling of humidity due eczematous changes) in the anorectal area.
Lidocaine has a local anesthetic effect, which is caused by the blockade of sodium channels voltazhzavisimyh that prevents the generation of pulses in sensory nerve endings and conducting pain impulses along nerve fibers. Combined effect of components of the drug yields the best effect.
Pharmacokinetics:
Heparin and prednisolone effectively absorbed following rectal administration, penetrate the intestinal wall for several hours, and then gradually be transported by the portal circulation to the liver, where biotransformed oxidizing enzyme into metabolites and excreted through the kidneys. The half-life of heparin is 1 – 1.5 hours, prednisolone – 18-36 hours.
For rectal application part Lidocaine (35%) is subjected to systemic absorption. The maximum concentration of lidocaine in the blood reaches after 2 hours. The lidocaine is quickly metabolized in liver and excreted through the kidneys. Part lidocaine undergoes enterohepatic circulation and is excreted in the feces. The half-life is from 1 to 3 hours.
Conditions of supply of pharmacies
Without recipe.
side effects
The drug is generally well tolerated. At the recommended dose of the drug adverse effects were detected. In applying the drug over 5 weeks are possible systemic side effects associated with the action of prednisone: Endocrine system: impaired glucose tolerance, “steroid” diabetes, suppression of adrenal function, Cushing’s syndrome.
On the part of the cardiovascular system are possible arrhythmia, bradycardia (in predisposed patients), ECG changes typical of hypokalemia, increased blood pressure. From the nervous system: insomnia, dizziness. Metabolism: increased excretion of calcium ions, hypocalcemia, increased sweating. Allergic reactions caused lidocaine and heparin in the form of itching and irritation of the anus.
Storage conditions
In dry protected from light at a temperature not higher than 25 ° C. Keep out of the reach of children.
Dosing and Administration
When an internal hemorrhoid suppository inserted into the rectum cavity 1-2 times a day. At external hemorrhoids suppository administered anus incompletely – its base should be palpable outside. Hold the anus gauze to complete melting of the suppository (2-3 minutes), or suppository “fail” in the rectum, without putting therapeutic action.
The course of treatment – 7 days. According to the doctor’s recommendation course can be extended to 14 days.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

ALTFARM

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