Genferon light suppositories vagin.-Recto. 125000me 5mg + 10 pcs

Description

Composition
Active substance:
1 suppository dosage to 125,000 IU 5 mg + 250 + 5 000 IU mg respectively comprises interferon alpha-2b – IU 125 000 250 000 IU; Taurine – 0,005 g
Excipients:
“Tallow”, dextran 60,000, macrogol 1500, polysorbate 80, emulsifier T2, sodium hydrocitrate, citric acid, purified water – sufficient quantity to obtain a suppository weight 0.8 g
Description:
White or white to yellowish white color suppositories cylindrical shape with a pointed end, in a longitudinal section homogeneous. On the cut tolerance of air core or funnel-shaped depressions.
Product form:
Rectal and vaginal suppositories 125,000 IU + 5 mg and 250 000 IU + 5 mg.
5 suppositories in blisters of aluminum foil or PVC film. 1 or 2 blisters together with instructions for use in a stack of cardboard.
Contraindications
Individual intolerance to interferon and other substances that make up the drug.
I trimester of pregnancy.
Carefully.
Exacerbation of allergic and autoimmune diseases.
Dosage
125 + 5 mg tysME
Indications
– As a component of complex therapy – for the treatment of acute respiratory viral infections and other infectious diseases of bacterial and viral etiology in children. – For the treatment of infectious and inflammatory diseases of the urogenital tract in children and women, including pregnant women, in the background are appointed and controlled by a doctor a specific therapy.
Interaction with other drugs
Genferon® Light is most effective as a component of complex therapy. When combined with antibacterial, fungicidal and antiviral drugs is observed mutual potentiation of action, to achieve high overall therapeutic effect.
Overdose
Light Genferona® no cases of overdose. When a random one-time introduction of a larger number suppositories than prescribed physician should suspend further administering for 24 hours, after which the treatment can be resumed on the prescribed pattern.
pharmachologic effect
Pharmacological group:
Immunomodulating agents, interferons.
Pharmacodynamics:
GENFERON® LITE – combined formulation, the effect of which is due to components in its composition.
It provides local and systemic effects.
The composition Genferon® Light preparation includes recombinant human interferon alpha-2b, produced by bacterial strain Escherichia coli, into which the genetically engineered gene introduced interferon alpha-2b human. Interferon alpha-2b has antiviral, immunomodulatory, antiproliferative and antibacterial effects. The antiviral effect is mediated by the activation of a number of intracellular enzymes that inhibit the replication of viruses. Immunomodulatory effects manifested, first of all, increased cell-mediated immune reactions, which increases the efficiency of the immune response against viruses, intracellular parasites and cells which have undergone a neoplastic transformation. This is achieved by activation of CD8 + killer T cells, NK-cells (natural killer cells), enhancing differentiation of B-lymphocytes and production of antibodies, activation of the monocyte-macrophage system and phagocytosis as well as increasing the expression of molecules of the major histocompatibility complex I type, which increases the likelihood recognition of infected cells by cells of the immune system. Activation of leucocytes under influence of the interferon contained in all mucosal layers provides them with an active part in the elimination of lesions; In addition, due to the effect of interferon is achieved by restoring the production of secretory immunoglobulin A. The antibacterial effect is mediated by the immune system enhanced by the influence of interferon.
Taurine contributes to the normalization of metabolic processes and tissue regeneration, has a membrane and immunomodulatory effects. As a potent antioxidant, taurine interacts directly with the active oxygen species, an excessive accumulation of which promotes the development of pathological processes. Taurine helps to preserve the biological activity of interferon, enhancing the therapeutic effect of the drug.
Pharmacokinetics:
With rectal administration it has a high bioavailability (80%) of interferon in connection with what is achieved by both local and systemic pronounced immunomodulating action; in intravaginal application due to the high concentration in the infected site and fixing the mucosal cells achieved a pronounced local antiviral, antiproliferative and antibacterial effect, with systemic effect due to low suction capacity of the vaginal mucosa is negligible. The maximum concentration of interferon in serum is reached after 5 hours after drug administration. The main route of excretion is an alpha interferon renal catabolism. half-life is 12 hours, which necessitates the use of the drug, 2 times a day.
Pregnancy and breast-feeding
Clinical studies have proven the efficacy and safety of the drug Genferon® Light in women in the 13-40 weeks of pregnancy. Application in I trimester of pregnancy is contraindicated.
No limitations to the use of lactation.
Conditions of supply of pharmacies
Without a prescription – suppositories, vaginal and rectal 125 000 IU + 5 mg.
Prescription – suppositories, vaginal and rectal 250 000 IU + 5 mg.
side effects
The drug was well tolerated by patients. Very rarely (frequency less than 1 in 10,000 cases): there are sporadic reports of cases of allergic reactions. These phenomena are reversible and disappear within 72 hours after cessation of administration. Continued treatment may, after consultation with the doctor.
Until now, there was no serious or life-threatening side effects.
special instructions
Genferon® Light does not affect the performance of potentially hazardous activities that require attention and fast reactions (management of vehicles, machinery, etc.).
Storage conditions
At a temperature of 2 to 8 ° C.
Keep out of the reach of children.
Dosing and Administration
The preparation can be applied both vaginally and rectally. Route of administration, dose and duration of the course depends on the age and the specific clinical situation.
In adults and children older than 7 years Genferon® Light is used in a dose of 250 000 IU of interferon alfa-2b per suppository.
Children up to 7 years, including infants, is safe to use the drug in a dose of 125 000 IU of interferon alfa-2b per suppository. Women who are at 13-40 weeks of pregnancy, the drug is used in a dose of 250 000 IU of interferon alfa-2b per suppository.
Recommended dosages and treatment regimens.
Acute respiratory viral infection and other acute viral disease in children: 1 suppository rectally 2 times a day with 12-hour intervals parallel to the main therapy for 5 days. If after 5 days of treatment reduced symptoms of the disease or become more pronounced, the patient should see a doctor. For clinical course possible repeated treatment after a 5-day interval.
Chronic infectious-inflammatory disease of viral etiology in children older than 7 years: 1 suppository (250 000 IU) rectally, 2 times a day with a 12-hour intervals parallel to the standard therapy for 10 days. Then, within 1-3 months – 1 suppository rectally at night through the day.
Acute infectious and inflammatory diseases of the urogenital tract in children: 1 suppository rectally 2 times a day with a 12-hour intervals for 10 days on the background are appointed and controlled by a doctor a specific therapy.
Infectious-inflammatory diseases of the urogenital tract in pregnant women: 1 suppository (250 000 IU) vaginally 2 times a day with a 12-hour intervals for 10 days on the background are appointed and controlled by a doctor a specific therapy.
Infectious-inflammatory diseases of the urogenital tract in women: 1 suppository (250 000 IU) vaginally or rectally (depending on the nature of the disease), 2 times a day with a 12-hour intervals for 10 days on the background are appointed and controlled by a doctor a specific therapy. In protracted forms 3 times a week, every other day 1 suppository for 1-3 months.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist