Geksoral Tabs tab for the races. 20 pc

Description

Composition
Active substance:
1 tablet contains: chlorhexidine dihydrochloride 5 mg, 1.5 mg benzocaine ;.
Excipients:
Isomalt – 2243.681 mg Peppermint oil – 0.9 mg Menthol – 0.645 mg, thymol – 0.045 mg Aspartame – 2.29 mg Purified water – 45.789 mg.
Description:
Opaque Round biconvex tablets with a rough surface from white or yellowish white to light gray or yellowish gray color. Avoid uneven staining, the presence of air bubbles and small jagged edges. Perhaps the appearance of white bloom (dusting).
Product form:
Lozenges. 10 tablets in a blister made of PVC / PVDC / Al foil. 2 in the blister cardboard pack together with instructions for use.
Contraindications
– hypersensitivity to any component of the drug; – wound and ulcerative lesions of the mouth or throat; – low concentrations of cholinesterase in the blood plasma; – phenylketonuria; – Children under 4 years old.
Carefully
When erosive, desquamative changes “Geksoral Tabs” oral mucosal drug can be used with caution and only under medical supervision.
Dosage
1.5 mg + 5 mg
Indications
Infectious and inflammatory diseases of the oral cavity or throat: pharyngitis, tonsillitis and other inflammatory diseases of the pharynx; stomatitis; gingivitis.
Interaction with other drugs
Benzocaine through the formation of its metabolite 4-aminobenzoic acid reduces the antibacterial activity of sulfonamides and aminosalicylates.
Sucrose, polysorbate 80, insoluble magnesium salts, zinc and calcium is reduced effect of chlorhexidine.
Overdose
When used properly, an overdose of the drug can not be, since the chlorhexidine is practically not absorbed into the blood, and the amount of intake of benzocaine is extremely small.
chlorhexidine
Chlorhexidine hydrochloride is poorly soluble in water, all cases of overdose described only when receiving highly water-soluble chlorhexidine gluconate. In these cases it was marked mucosal damage by direct contact with chlorhexidine gluconate, as well as systematic reversible increase of liver enzyme concentrations. Specific treatment is absent.
benzocaine
Overdosing is possible only if used incorrectly.
Symptoms: possible toxic effects on the central nervous system, manifesting itself first tremor, vomiting, cramps, and later – CNS depression. Due to respiratory depression possible coma. High toxic concentrations cause bradycardia, atrioventricular conduction blockade, and cardiac arrest. Benzocaine can cause methemoglobinemia (especially in children), followed by choking and cyanosis.
Treatment: Induce vomiting and stomach wash. Perhaps the appointment of activated carbon. In hypoxia and anoxia recommended artificial respiration with oxygen support during cardiac arrest – cardiac massage. In convulsions prescribed diazepam or fast barbiturates (contraindicated in anoxic convulsions); in severe cases, after intubation and respirator use suxamethonium chloride. Circulation must be maintained by introducing the blood plasma or electrolyte solutions. When methemoglobinemia can be applied to 50 ml of a 1% solution of methylene blue intravenously.
pharmachologic effect
Pharmacodynamics:
Dual effect of the drug caused by the presence of two active substances. The antibacterial activity of the drug due to the presence of chlorhexidine. The action of the local anesthetic – benzocaine – reduces pain symptoms.
chlorhexidine
Chlorhexidine has a broad antibacterial spectrum of action against gram-positive and gram-negative bacteria; It acts by disrupting the plasma membrane of bacterial cells. Nizkoeffektiven against yeasts, dermatophytes, mycobacteria, some species of Pseudomonas and Proteus.
Chlorhexidine is most effective in a neutral or slightly alkaline environment. In the acidic medium decreases its activity. Efficiency is reduced in the presence of soaps, blood and purulent discharge.
Application lozenges with chlorhexidine results in a significant reduction of the content of bacteria in saliva. The use of chlorhexidine for a few months, accompanied by a reduction of its efficiency by reducing the sensitivity of bacteria.
benzocaine
Benzocaine – a well-known local anesthetic, quickly and for a long time, relieves pain in the mouth and throat. Benzocaine lipophilic portions penetrates the cell membrane and acts on the peripheral pain receptors of the skin and mucosa. Benzocaine anesthetic effect occurs within 15-30 seconds; as saliva dilution substance anesthetic effect gradually decreases (within 5-10 minutes).
Pharmacokinetics:
chlorhexidine
No clinical data chlorhexidine absorption through the oral mucosa of man. Chlorhexidine may be stored in the saliva to 8 hours.
benzocaine
Benzocaine is poorly soluble in water, which leads to its slow absorption. Like all ester derivatives of para-aminobenzoic acid, splits esterase in the blood plasma and liver. As a result, formed of p-aminobenzoic acid and ethyl alcohol, is metabolized to acetyl coenzyme A. Para-aminobenzoic acid undergoes conjugation with glycine or excreted by the kidneys unchanged.
Pregnancy and breast-feeding
There is no sufficient experience with the drug in pregnant and lactating women.
The use of “Geksoral Tabs” of the drug during pregnancy and lactation is possible only in cases where the expected benefit to the mother outweighs the potential risk of harmful effects to the fetus and child.
Conditions of supply of pharmacies
Without recipe.
side effects
Adverse reactions revealed by post-registration application of the drug, were classified as follows: very frequent (> 10%), frequent (> 1%, but
special instructions
No special requirements.
Children can use the drug to an age when there is no danger of uncontrolled swallowing it, or when they do not oppose foreign object (nozzle – spray) in the mouth when using aerosol and able to hold their breath when injecting the drug.
The ethanol content in the formulation is 5.15%. One dose of the preparation contains 20.3 mg of ethanol (in terms of absolute alcohol).
The contents of the aerosol container is pressurized. Do not open, do not pierce or burn, even if the container is empty.
If the drug had deteriorated st or expired shelf life – do not pour it into the waste water and not be thrown into the street! Place the drug in the bag and place in the trash. These measures will help protect the environment!
The drug “Geksoral®” spray for topical use does not affect the ability to drive and engage in other potentially hazardous activities.
Storage conditions
Store at a temperature not higher than 25 C. Keep out of reach of children.
Dosing and Administration
Locally. The tablet slowly dissolve in the mouth until complete dissolution.
The drug should be used to start immediately after the appearance of the first symptoms of the disease and continue to receive within a few days after symptoms disappear.
General dosing recommendations
Adults and children over 12 years
1 tablet every 1-2 hours as needed, but no more than 8 tablets daily, unless designated otherwise.
Children aged 4-12 years
Up to 4 tablets per day.
Regarding the use of children to consult with your doctor.
Do not apply to children under 4 years.
Information for diabetics: carbohydrate content in one tablet corresponds to 0.1 grain units (BU).
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist