Furazolidone 50mg tabs 10 pcs aveksima

Description

Composition
Active substance:
1 tablet contains: Furazolidone – 0.05g ;.
Excipients:
– potato starch – 0.02g, calcium stearate (calcium stearate) – 0.001 g sugar (sucrose) – 0.01 g, Tween-80 (polysorbate) – 0.0002 g lactose (milk sugar) – 0.0188 city
Description:
Tablets of yellow or greenish-yellow color, Valium chamfered.
Product form:
Tablets of 50 mg.
10 tablets in blisters.
50 tablets in a jar of polymeric materials. 1, 2, 3, 4 or 5 of cellular contour packs or one bank of polymer materials with instructions for medical use in a pile of cardboard.
Contraindications
Pregnancy, lactation. Individual hypersensitivity to the nitrofurans group. End-stage chronic renal failure, deficiency of glucose-6-phosphate dehydrogenase, children under 3 years (for a given dosage form).
Precautions: chronic renal failure, deficiency of glucose-6-phosphate dehydrogenase, liver and nervous system.
Dosage
50 mg
Indications
Dysentery, paratyphoid fever, giardiasis, food poisoning.
Interaction with other drugs
Furazolidone in combination with ethanol can lead to disulfiramopodobnyh reactions, in this connection, while keeping them is not recommended.
Antidepressants, monoamine oxidase inhibitors, ephedrine, amphetamine, phenylephrine, tyramine can cause a sharp rise in blood pressure.
Overdose
Symptoms of acute toxic hepatitis, hematotoxicity, neurotoxicity (polyneuritis).
Treatment: removal of drugs, drinking large amounts of fluid, symptomatic therapy, antihistamine drugs, vitamins of group B.
pharmachologic effect
Pharmacological group:
Antimicrobial and protivoprotozoynoe means.
Pharmacodynamics:
The antimicrobial agent, nitrofurans derivative. It is active against gram-positive and gram-negative bacteria, Trichomonas spp., Giardia lamblia. Most sensitive to furazolidone Shigella dysenteria spp., Shigella flexneri spp., Shigella boydii spp., Shigella sonnei spp., Salmonella typhi, Salmonella paratyphi. Little effect on the pathogens of purulent and anaerobic infections. Resistance of microorganisms is slow. Monoamine oxidase blocks.
Nitrofurans violate cell respiration of microorganisms, inhibit the tricarboxylic acid cycle (Krebs cycle), and also inhibit the biosynthesis of nucleic acids of microorganisms, resulting in the destruction of their cytoplasmic membranes or membrane. As a result of nitrofurans microorganisms produce less toxins, and therefore the improvement of the general state of the patient may still be expressed to suppress the growth of the microflora. In contrast to many other antimicrobial drugs they not only inhibit and even activate the immune system (increased complement titer and ability of leukocytes phagocytose microorganisms).
Pharmacokinetics:
It is well absorbed after oral administration. Against the background of an inflammation of the meninges into the cerebrospinal fluid concentrations are equal to those in the plasma. Rapidly and extensively metabolized mainly in the liver to produce pharmacologically inactive metabolite (amino compound). Write mainly kidneys (65%), small amounts detected in the feces, where the therapeutic concentration is achieved against pathogens of intestinal infections.
Conditions of supply of pharmacies
Without recipe.
side effects
Loss of appetite, until anorexia; nausea, vomiting; allergic reactions (rash, redness and itching of the skin, angioneurotic edema).
With prolonged use – neuritis.
special instructions
Increases blood oppression against the background of chloramphenicol and ristomycin.
Increases sensitivity to ethanol. Medicaments urine alkalizing reduce the effect, and acidifying – increase.
Aminoglycosides and tetracycline enhance the antimicrobial properties.
In the course of treatment should take precautions, like using a monoamine oxidase inhibitor, such as: exclusion from the diet products that contain thiamine: cheese, cream, beans, pickled herring, strong coffee.
For the prevention of long-term use of neuritis must be combined with vitamins of group B.
Storage conditions
Store in a dry, dark place ..
Keep out of the reach of children.
Dosing and Administration
Inside, after a meal. In dysentery, paratyphoid and nutritional diseases – at 100- 150 mg four times a day (not to exceed 800mg) for 5-10 days.
When giardiasis – adults from 100 mg 4 times a day for children at 10 mg / kg / day, spreading the daily dose into 3-4 doses.
The highest single dose for adults: 200 mg daily – 800 mg.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist