Folic acid 1mg tab 50 pcs ozone

Description

Composition
Active substance:
1 tablet contains: folic acid 1 mg.
Product form:
Packaging The tablets 50 tablets.
Contraindications
Hypersensitivity.
Be wary of pernicious anemia and other megaloblastic anemia with deficiency of cyanocobalamin.
Dosage
1 mg
Indications
Treatment macrocytic (folic acid) deficiency anemia. Hypo- and folic acid deficiency disease, including in tropical and non-tropical sprue, malnutrition, pregnancy, in patients taking antiepileptic, contraceptive drugs.
Interaction with other drugs
Reduces the effect of phenytoin (dose required to increase it). Analgesics (chronic treatment), anticonvulsants (including phenytoin and carbamazepine), estrogens, oral contraceptives increase the demand for folic acid. Antacids (including drugs Ca2 +, Al3 + and Mg2 +), cholestyramine, sulfonamino (including sulfasalazine) reduce the absorption of folic acid. In order to prevent the development of megaloblastic anemia patients receiving cytostatics (methotrexate) or antiepileptic drugs recommended concomitant administration of folic acid. Pyrimethamine, triamterene, trimethoprim inhibit dihydrofolate reductase and reduced folate effect (instead of patients treated with these drugs should be given calcium folinate). With regard to drugs Zn2 + unique information is not some studies suggest that folate inhibit the absorption of Zn2 +, others refute this data.
Overdose
doses of folic acid to 4 – 5 mg are well tolerated. Higher doses may cause disorders of the central nervous system (irritability and insomnia) and gastrointestinal (nausea, abdominal pain, bloating).
pharmachologic effect
Pharmacological properties:
Pharmacodynamics Folate – B vitamin (vitamin B9) can be synthesized by intestinal microflora. In the body, folic acid is reduced to tetrahydrofolic acid, a coenzyme participating in various metabolic processes. It is essential for normal maturation and education megaloblasts normoblasts. Stimulates erythropoiesis, is involved in the synthesis of amino acids (including glycine, methionine), nucleic acids, purines, pyrimidines, exchangeable choline, histidine. Pharmacokinetics Folic acid, administered as a medicament well and completely absorbed in the gastrointestinal tract, preferably in the upper duodenum 12 (even with malabsorption syndrome on the background tropical sprue, while dietary folates poorly absorbed in the syndrome of malabsorption ). Extensively bound to plasma proteins. It penetrates the blood-brain barrier, the placenta and breast milk. TCmax – 30 – 60 min. Deposited and metabolized in the liver to form tetrahydrofolic acid (in the presence of ascorbic acid by the action of dihydrofolate reductase). Excreted by the kidneys mainly as metabolites; if the received dose considerably higher than the daily requirement of folic acid, it is excreted unchanged. Displayed by hemodialysis. Analogs of the composition of Valens, RossiyaKapsuly476 rubles.
Pregnancy and breast-feeding
The drug is used according to indications during pregnancy and lactation. Daily intake of folic acid in early pregnancy may prevent neural tube defects (anencephaly, spina bifida). If the drug is started after the fourth week of pregnancy, folic acid has no effective action to prevent neural tube defects.
Conditions of supply of pharmacies
Available without prescription.
side effects
Skin rash, itchy skin, bronchospasm, erythema, hyperthermia. When you see any side effects not described in this manual, you should inform your doctor.
special instructions
The drug is not intended for the prevention of hypo-and vitamin deficiency in children (due to the mismatch of the daily requirement and dosing drugs). For preventing hypovitaminosis B9 most preferably balanced nutrition. Foods rich in vitamin B9 – green vegetables (lettuce, spinach, tomatoes, carrots), fresh liver, beans, beets, eggs, cheese, nuts and grains. Folic acid is not applicable for the treatment of B12-deficiency (pernicious) normocytic and aplastic anemia, and anemia refractory to therapy. In pernicious (B12 deficiency) folic acid deficiency anemia, improving hematological indicators masks neurological complications. While not excluded pernicious anemia, folate purpose in doses exceeding 0.1 mg / day, are not recommended (exception – pregnancy and lactation). It should be borne in mind that patients undergoing hemodialysis require high amounts of folic acid. During treatment antacids should be applied after 2 h after administration of folic acid, cholestyramine – 4 – 6 h before or after 1 h after folic acid. It should be borne in mind that antibiotics can distort (knowingly give underestimated parameters) assessment of microbiological folate concentrations plasma and erythrocytes. When large doses of folic acid, as well as therapy for a long period may decrease blood concentration of vitamin B12 (cyanocobalamin). Prolonged use of folic acid is recommended to be combined with intake of vitamin B12. Effect on ability to drive and work with moving machinery is not affected.
Storage conditions
In a dry place, protected from light at a temperature not higher than 25 ° C.
Dosing and Administration
Folic acid is taken orally. Before eating. For the treatment of macrocytic (folic acid) deficiency anemia prescribed for adults and children of any age initial dose – 1 mg per day (one tablet). At high doses may occur resistance. Supportive care for children over 4 years of age and adults – 0.5 mg (1/2 tablet) during pregnancy and lactation – to 1 mg per day. Pregnant women for the prevention of neural tube defects in the fetus – 0.5 mg per day (half tablets) to 2.5 mg per day (2.5 tablets) for 4 weeks prior to pregnancy. The reception continued for I trimester of pregnancy. With the purpose of treatment (depending on the severity beriberi) adults – 5 mg per day (5 tablets) for 20-30 days, children – depending on their age. Therapeutic doses of folic acid defined by the doctor. With concomitant alcoholism, hemolytic anemia, chronic infectious diseases, simultaneous administration of anticonvulsant drugs after gastrectomy, malabsorption syndrome, hepatic at failure, liver cirrhosis, stress dose should be increased drug.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist