Fluimucil Table spike. 600mg 10 pieces

Description

Composition
Active substance:
1 tablet contains: 600 mg acetylcysteine ​​;.
Excipients:
Citric acid, sodium hydrogen carbonate, aspartame, lemon flavoring.
Description:
White round rough surface lemon tablets slightly sulfur odor.
The solution preparation, the resulting tablet a water recovery should be slightly opalescent, with a characteristic smell and taste of lemon flavoring.
Product form:
Effervescent tablets of 600 mg.
2 or 10 tablets in blisters (blister) made of laminated aluminum foil [polyamide – aluminum – polyethylene / polyethylene – aluminum].
According to I or 2 blisters (10 tablets) or for 5 or 10 blisters (2 tablets), together with instructions for use placed in a cardboard box.
Contraindications
Hypersensitivity to acetylcysteine, gastric ulcer and duodenal ulcer in the acute stage, children under 18 years of age, the period of lactation.
Be wary – Peptic ulcer and 12 duodenal ulcer, varicose veins of the esophagus, hemoptysis, pulmonary hemorrhage, phenylketonuria, bronchial asthma, diseases of the adrenal glands, liver and / or kidney failure, hypertension.
Dosage
600 mg
Indications
Violation expectoration bronchitis, tracheitis, bronchiolitis, pneumonia, bronchiectasis, cystic fibrosis, lung abscess, emphysema, laryngotracheitis, interstitial lung disease, pulmonary atelectasis (due to mucous obstruction of bronchi stopper). Catarrh and purulent otitis media, sinusitis, sinusitis (promoting the removal of secretions).
Removal of viscous secretions from the airways in post-traumatic and postoperative states.
Interaction with other drugs
Combined use with acetylcysteine ​​antitussives can enhance stagnation sputum because of suppression of the cough reflex. While the use of such antibiotics as tetracyclines (doxycycline excluding), ampicillin, amphotericin B, possibly their interaction with a thiol group acetylcysteine, which leads to reduced activity of both drugs. Therefore, the interval between doses of the /? drugs must be at least 2 hours.
Simultaneous treatment with acetylcysteine ​​and nitroglycerin may result in increased vasodilator and antiplatelet actions of the latter. Acetylcysteine ​​eliminates the toxic effects of paracetamol.
Overdose
Acetylcysteine ​​when receiving a dose of 500 mg / kg / day does not cause signs and symptoms of an overdose.
pharmachologic effect
Pharmacological group:
Expectorant mucolytic agent.
Pharmacodynamics:
Mucolytic agent, liquefies phlegm and increases its volume, facilitates the separation of sputum. The action related to the ability of sulfhydryl vobodnyh ipynn acetylcysteine ​​sever intra- and intermolecular disulfide bonds acid mucopolysaccharides sputum, leading to depolymerization mukoproteinov and reduce the viscosity of sputum. Retains activity when purulent sputum.
Increases secretion less viscous sialomutsinov goblet cells, reduces the adhesion of bacteria to the epithelial cells of the bronchial mucosa. Stimulates mucosal cells of the bronchi, the secret of which lyses fibrin. A similar effect on the secretion produced in inflammatory diseases of upper respiratory tract. It has an antioxidant effect due to the presence of SH-groups that can neutralize electrophilic toxins oxidation. Acetylcysteine ​​easily penetrates into cells, deacetylated to L-cysteine, which is synthesized from the intracellular glutathione. Glutathione – highly reactive tripeptide powerful antioxidant cytoprotector, trapping endogenous and exogenous toxins and free radicals. Acetylcysteine ​​prevents depletion and contributes to intracellular synthesis of glutathione involved in redox processes of cells, thereby contributing to detoxification of harmful substances. This explains the effect of acetylcysteine ​​as an antidote for poisoning by paracetamol.
It protects the alpha 1-antitrypsin (elastase inhibitor) from inactivation NOS1 – oxidant active myeloperoxidase produced by phagocytes. Also has anti-inflammatory action (by inhibiting the formation of free radicals and active oxygen-containing compounds are responsible for the development of inflammation in lung tissue).
Pharmacokinetics:
Fluimucil is well absorbed after oral administration. He immediately deacetylated to cysteine ​​in the liver. In the blood, there is dynamic equilibrium with the free and bound plasma proteins acetylcysteine ​​and its metabolites (cysteine, cystine, diatsetiltsisteina). Due to the high effect of “first pass” through the liver acetylcysteine ​​bioavailability is about 10%. Acetylcysteine ​​penetrates into the extracellular space, mainly distributed in liver, kidney, lung / bronchial secretions.
The maximum concentration reached in 1-3 hours after oral administration and is 15 mmol / l, the connection with plasma proteins in plasma – 50%. T1 / 2 – about 1 hour, liver cirrhosis increases to 8 hours excreted by the kidneys in the form of inactive metabolites (inorganic sulfates diatsetiltsistein), a small part is released in an unmodified form through the intestine.. It crosses the placental barrier.
Pregnancy and breast-feeding
The drug is administered during pregnancy only if the expected benefit to the mother outweighs the potential risk to the fetus.
If necessary, the appointment during lactation should stop breastfeeding.
Conditions of supply of pharmacies
Without recipe.
side effects
In rare cases: nausea, heartburn, feeling of fullness, vomiting, diarrhea, skin rash, pruritus, urticaria, epistaxis, tinnitus. When receiving acetylcysteine ​​described cases of bronchospasm, collapse, stomatitis, reduce platelet aggregation.
special instructions
Patients with bronchial asthma and obstructive bronchitis acetylcysteine ​​should be used with caution under systematic control of bronchial obstruction. The drug contains aspartame, therefore not recommended for use in patients with phenylketonuria.
The presence of lung sulfur odor is characteristic odor of the active substance.
When dissolving acetylcysteine ​​glassware must be used to avoid contact with metal and rubber surfaces.
Storage conditions
Store at a temperature not higher than 25 ° C. Keep out of the reach of children.
Dosing and Administration
Inside. Adults: 1 effervescent tablet 600 mg was dissolved in 1/3 glass of water and taken once daily.
The duration of treatment should be evaluated individually. In acute diseases duration of treatment is from 5 to 10 days; in the treatment of chronic diseases – up to several months (on doctor’s advice).
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist