Fluimucil solution and / for inhalation. 100mg / ml 3 ml ampoules 5 pcs


Fluimucil solution and / for inhalation. 100mg / ml 3 ml ampoules 5 pcs


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Active substance:
1 ml of solution contains: NAC – 100 mg ;.
Disodium edetate, Sodium hydroxide, Water for injection.
Transparent, colorless liquid with a slight sulfur odor.
After opening the ampule during prolonged contact with air may appear faint pink-purple hue.
Product form:
A solution for injection and inhalation of 100 mg / ml.
Ampoules 3 ml amber glass Tagged notching.
5 vials in a plastic tray with instructions for medical application is placed in a cardboard pack.
Hypersensitivity, gastric ulcer and duodenal ulcer in the acute stage, the period of lactation.
Precautions – Gastric ulcer and duodenum 12 in remission, varicose veins, the esophagus, hemoptysis, pulmonary hemorrhage, asthma (with / in a risk of developing bronchoconstriction), adrenal disease, liver and / or kidney failure, hypertension , children under 6 years. Children under the age of 1 year / in the introduction of acetylcysteine ​​is only possible on “real life” testimony in the hospital.
Violation expectoration bronchitis, tracheitis, bronchiolitis, pneumonia, bronchiectasis, cystic fibrosis, lung abscess, emphysema, laryngotracheitis, interstitial lung disease, pulmonary atelectasis (due to mucous obstruction of bronchi stopper). Catarrh and purulent otitis media, sinusitis, sinusitis (promoting the removal of secretions).
Removal of viscous secretions from the airways in post-traumatic and postoperative states.
Preparing for bronchoscopy bronhografii, aspiration drainage. For washing abscesses, nasal passages, sinuses, middle ear; processing fistula surgical field during operations in the nasal cavity and the mastoid.
Interaction with other drugs
Combined use with acetylcysteine ​​antitussives can enhance stagnation sputum because of suppression of the cough reflex. While the use of such antibiotics as tetracyclines (doxycycline excluding), ampicillin, amphotericin B, possibly their interaction with a thiol group acetylcysteine, which leads to reduced activity of both drugs. Therefore, the interval between doses of these drugs should be at least 2 hours.
Pharmaceutically compatible with other medicaments solutions. Simultaneous treatment with acetylcysteine ​​and nitroglycerin may lead to increased vasodilatory action of the latter.
Acetylcysteine ​​eliminates the toxic effects of paracetamol.
Acetylcysteine ​​when receiving a dose of 500 mg / kg / day does not cause signs and symptoms of an overdose.
pharmachologic effect
Pharmacological group:
Expectorant mucolytic agent.
Mucolytic agent, liquefies phlegm and increases its volume, facilitates the separation of sputum. The action associated with the ability of free sulfhydryl groups acetylcysteine ​​break intra- and intermolecular disulfide bonds, acid mucopolysaccharides mucus, resulting in depolymerization and reduction of viscosity mukoproteinov / sputum. Retains activity when purulent sputum.
Increases secretion less viscous sialomutsinov goblet cells, reduces the adhesion of bacteria to the epithelial cells of the bronchial mucosa. Stimulates mucosal cells of the bronchi, the secret of which lyses fibrin. A similar effect on the secretion produced in inflammatory diseases of upper respiratory tract. It has an antioxidant effect due to the presence of SH-groups that can neutralize electrophilic toxins oxidation. Acetylcysteine ​​easily penetrates into cells, deacetylated to L-cysteine, which is synthesized from the intracellular glutathione. Glutathione – highly reactive tripeptide powerful antioxidant cytoprotector, trapping endogenous and exogenous toxins and free radicals. Acetylcysteine ​​prevents depletion and contributes to intracellular synthesis of glutathione involved in redox processes of cells, thereby contributing to detoxification of harmful substances. This explains the effect of acetylcysteine ​​as an antidote for poisoning by paracetamol.
Protects alpha1-antitrypsin (elastase inhibitor) from inactivation NOS1 – oxidant active myeloperoxidase produced by phagocytes. Also has anti-inflammatory action (by inhibiting the formation of free radicals and active oxygen-containing compounds are responsible for the development of inflammation in lung tissue).
When administered intravenously, 600 mg acetylcysteine ​​maximum plasma concentration is 300 mmol / l, the plasma half-life – 2 hr. The total clearance is 0.21 l / h / kg, a volume of distribution equal to plateau at 0.34 l / kg.
The liver deacetylated to cysteine. In the blood, there is dynamic equilibrium with the free and bound plasma proteins acetylcysteine ​​and its metabolites (cysteine, cystine, diatsetiltsisteina). Acetylcysteine ​​penetrates into the extracellular space, mainly distributed in liver, kidney, lung, bronchial secretions.
Excreted by the kidneys in the form of inactive metabolites (inorganic sulfates diatsetiltsistein), a small part is released in an unmodified form through the intestine.
It crosses the placental barrier.
Pregnancy and breast-feeding
The drug is administered during pregnancy only if the expected benefit to the mother outweighs the potential risk to the fetus.
Conditions of supply of pharmacies
On prescription.
side effects
When aerosol therapy: a reflex cough, respiratory irritation, rhinorrhea; rarely – stomatitis, bronchospasm. When the / m – burning at the injection site, skin rash, urticaria; long-term treatment – dysfunction of the liver and / or kidney.
special instructions
Patients with bronchial asthma and obstructive bronchitis acetylcysteine ​​should be used with caution under systematic control of bronchial obstruction. When shallow / m administration of the drug and in the presence of hypersensitivity can occur easily and rapidly undergoing burning, and therefore is recommended to inject drug deep into the muscle.
Fluimucil ampoule is opened before use. The opened ampoule can be stored in a refrigerator for 24 hours, during which time the preparation can only be used for inhalations.
Fluimucil solution must not come into contact with the rubber and metal surfaces.
Storage conditions
At a temperature of 15 ° C – 25 ° C. Keep out of the reach of children.
Dosing and Administration
Inhalation. For aerosol therapy ultrasound spray devices 3-9 ml of 10% solution in devices with pilot valve – 6 ml of a 10% solution. The duration of inhalation – 15-20 minutes; multiplicity – 2-4 times a day. In the treatment of acute conditions the average duration of therapy – 5-10 days; during long-term treatment of chronic conditions, the course of treatment – up to 6 months.
Due to the high safety of the drug and the relative frequency of the received dose value may be changed physician within acceptable limits, depending on the patient and the therapeutic effects. No need to change the adult dose in the case of the drug for the treatment of children. In the case of strong action sekretoliticheskim secret aspirated and inhalation rate and reduce the daily dose. Intratracheally. For washing the bronchial tree when using therapeutic bronchoscopy 1-2 ampoules or more per day, depending on clinical indications.
Locally. Buried in the external auditory canal and nasal passages 150-300 mg (1.5-3 ml) for 1 procedure.
Parenterally. Introduced into / in (preferably slowly drip or bolus – within 5 minutes) or / m. Adults – 300 mg (3 ml) 1-2 times a day. Children 6 to 14 years – 150 mg (1.5 ml) 1-2 times a day. Children under the age of 6 preferred oral medication. The daily dose for children under 6 years – 10 mg / kg body weight, for children up to 1 year / with the introduction of acetylcysteine ​​is only possible on “real life” testimony in the hospital. The duration of treatment should be installed on the results of the patient’s condition changes.
High local and general tolerability allows for prolonged courses of treatment.
For on / in the solution was further diluted with 0.9% NaCl solution or 5% dextrose solution in a ratio of 1: 1. The duration of treatment is determined individually (maximum 10 days).
In patients older than 65 years – Use the lowest effective dose.
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg


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