Fluimucil antibiotic um lyophilisates for solution and for Inh. 500mg vial 3 pcs

$58.90

Fluimucil antibiotic um lyophilisates for solution and for Inh. 500mg vial 3 pcs

Quantity:

Description

Composition
Active substance:
Thiamphenicol glycinate atsetiltsisteinat – 810 mg (calculated as thiamphenicol -. 500 mg).
Excipients:
Disodium edetate.
1 ampoule of solvent: water for injection.
Description:
The contents of the vial: White or light yellow mass of the leaf with a slight sulfur smell.
The contents of the ampoule: Clear, colorless and odorless liquid and taste.
Product form:
Lyophilizate for preparation of solution for injections and inhalations of 500 mg. By 810.0 mg lyophilisate for solution for injection and inhalation colorless glass vials (Type I), capped hlorbutilkauchukovoy stopper and an aluminum cap at break in. 4.0 ml of water for injections in a colorless glass vials (type I).
3 lyophilisate vial complete with 3 ampoules solvents in a plastic tray, together with instructions for use in a cardboard pack.
Contraindications
Hypersensitivity to one of the formulation components; anemia, leukopenia, thrombocytopenia.
Carefully
When liver failure and chronic renal failure. In children, the first two years of life due to the age characteristics of renal function.
Dosage
500 mg
Indications
Fluimucil IT antibiotic used for the treatment of infectious and inflammatory diseases caused by microorganisms susceptible to the drug and accompanied mukostazom.
Diseases of the upper respiratory tract and ENT: exudative otitis media, sinusitis, laryngotracheitis.
Lower respiratory tract disease: acute and chronic bronchitis, prolonged pneumonia, lung abscess, emphysema, bronchiectasis, cystic fibrosis, bronchiolitis, whooping cough.
Prevention and treatment of bronchopulmonary complications following thoracic surgery (pneumonia, atelectasis). Prevention and treatment of obstructive or infectious complications of tracheostomy, preparation for bronchoscopy bronhoaspiratsii.
In the accompanying non-specific forms of respiratory infections for improving drainage, including cavernous foci, with mycobacterial infections.
Interaction with other drugs
The simultaneous appointment of antitussives can strengthen stagnation of sputum because of suppression of the cough reflex. Do not mix with other drugs in an aerosol.
special instructions
During treatment should be monitored picture peripheral blood. By reducing the number of leukocytes (less than 4 th. / L) and granulocytes (over 40%) drug overturned.
A solution of antibiotic-Fluimutsila® IT must not come into contact with metal surfaces and rubber. Fluimutsil® antibiotic IT does not affect the ability to drive vehicles and other mechanisms.
Overdose
Symptoms: changes in the bacterial flora, superinfection. Possibly increased side effects of the drug (except allergic reactions). Recommended maintenance therapy.
pharmachologic effect
Pharmacological group:
The antibiotic combination (antibiotic mucolytic +).
Pharmacological properties:
Antibacterial, expectorant ,.
Pharmacodynamics:
Thiamphenicol glycinate atsetiltsisteinat – a complex compound brings together thiamphenicol antibiotic and mucolytic acetylcysteine. After absorption tiaminfenikola glycinate atsetiltsisteinat split into acetylcysteine ​​and thiamphenicol. Thiamphenicol is a derivative of chloramphenicol, the mechanism of action associated with inhibition of protein synthesis of the bacterial cell. Thiamphenicol has a broad spectrum of antibacterial action, is effective in vitro against bacteria that most commonly cause respiratory tract infections: Gram positive (Streptococcus pneumoniae, Corynebacterium diphtheriae, Staphylococcus spp, Streptococcus pyogenes, Listeria spp, Clostridium spp…) And gram negative (Haemophilus influenzae, Neisseria spp., Salmonella spp., Escherichia coli, Shigella spp., Bordetella pertussis, Yersinia pestis, Brucella spp., Bacteroides spp.).
Acetylcysteine, breaking disulfide bonds mukoproteidov quickly and effectively liquefies mucus, pus, reduces their viscosity and promotes discharge. Acetylcysteine ​​facilitates penetration of the antibiotic thiamphenicol in lung tissue, inhibits the adhesion of bacteria on airway epithelium.
Pharmacokinetics:
Thiamphenicol rapidly distributed in the organism is accumulated in the tissues of the respiratory tract at therapeutic concentrations (the ratio of tissue / plasma concentration is about 1). Maximum plasma concentration achieved after 1 hour after intramuscular administration. The half clearance is about 3 hours, the distribution volume of 40 – 68 l. Binding to plasma proteins and 20%. Excreted by the kidneys by glomerular filtration, 24 hours after the administration, the amount of unchanged in urine thiamphenicol is 50-70% of the administered dose. It crosses the placental barrier. Acetylcysteine ​​after application rapidly distributed in the body, the half-life was 2 h. The liver deacetylated to cysteine. In the blood, there is dynamic equilibrium with the free and bound plasma proteins acetylcysteine ​​and its metabolites (cysteine, cystine, diatsetiltsisteina). Acetylcysteine ​​penetrates into the extracellular space, mainly distributed in liver, kidney, lung, bronchial secretions. Excreted by the kidneys in the form of inactive metabolites (inorganic sulfates diatsetiltsistein), a small part is released in an unmodified form through the intestine. It crosses the placental barrier.
Pregnancy and breast-feeding
In pregnancy, the drug is prescribed only if the potential benefit to the mother outweighs the potential risk to the fetus. If necessary, the appointment during lactation should stop breastfeeding during treatment.
Conditions of supply of pharmacies
On prescription.
side effects
Allergic reactions.
In intramuscular perhaps a slight burning sensation at the injection site, rarely – reticulocytopenia, anemia, leukopenia, neutropenia, thrombocytopenia.
If inhaled – reflex cough, local irritation of the respiratory tract, stomatitis, rhinitis, nausea. Possible bronchospasm, in this case, the prescribed bronchodilators.
special instructions
During treatment should be monitored picture peripheral blood. By reducing the number of leukocytes (less than 4 th. / L) and granulocytes (over 40%), drug overturned. Use during pregnancy and lactation is possible only if the potential benefit to the mother outweighs the potential risk to the fetus or newborn.
Storage conditions
At a temperature of 15 ° C to 25 ° C. Keep out of the reach of children.
Dosing and Administration
Fluimucil IT antibiotic administered intramuscularly, used for inhalations, applications, washing the cavities.
Inhalation: adults – 250 mg 1-2 times a day; children – 125 mg 1-2 times a day.
Endotracheal: through the bronchoscope, endotracheal tube, tracheostomy – 1-2 ml of solution (adult dissolved in 4 ml of water for injections – 500 mg of dry matter, for children – 250 mg).
Local: for administration to the sinuses, as well as for washing the cavities after surgery in the nasal area and mastoid 1-2 ml of solution (adult dissolved in 4 ml of water for injections – 500 mg of dry matter, for children – 250 mg ).
In diseases of the ear and the nasopharynx instill 2-4 drops into each nostril or the external auditory meatus.
Intramuscular: Adults – 500 mg 2-3 times a day; children up to 3 years – on 125 mg 2 times a day; 3-7 years – 250 mg 2 times a day; 7-12 years – 250 mg 3 times a day.
For premature infants and children up to 2 weeks, the average dose – 25 mg / kg per day.
If necessary, the dose may be increased by 2 times (during the first 2-3 days of treatment in severe cases). You can not increase the dose in premature and newborn babies, as well as in patients older than 65 years.
The course of treatment – no more than 10 days.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Zamboni

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