Flebofa tab 600mg 30 pieces

Description

Composition
Active substance:
1 tablet contains: diosmin, based on the anhydrous substance – 600 mg.
Product form:
Tablets of 600 mg of 30 tablets in the package.
Contraindications
Increased sensitivity to the drug; Children up to age 18 years (application experience is limited); pregnancy (I term) and lactation (application experience is limited).
Dosage
600 mg
Indications
Varicose veins (elimination of symptoms); lymphovenous chronic insufficiency of the lower extremities (elimination of symptoms); acute hemorrhoids (in the complex therapy to relieve symptoms); microcirculation disorders (e.g., idiopathic edema).
pharmachologic effect
Pharmacological group:
Angioprotective means.
Pharmacological properties:
Diosmin is benzopyrone derivatives. It refers to the group of bioflavonoids, and has flebotoniziruyuschim venoprotektornym action reduces vascular permeability. It reduces stretch and improves the tone of veins reduces venous stasis in the lower extremities. Diosmin venous effect is dose-dependent. Mechanism venotonic Diosmin has not been fully elucidated. It is assumed that the drug inhibits the activity of catechol-O-methyltransferase (enzyme degradation carrying noradrenaline, which increases the tone of veins). This hypothesis was confirmed in experimental studies (in terms «ex vivo» diosmin enhanced the vasoconstriction action of adrenaline, noradrenaline and serotonin on the isolated fragments of the superficial veins of the forearm and the human great saphenous vein). It was also shown that diosmin reduces the serum content of the enzymes responsible for the metabolism of mucopolysaccharides in the venous wall. In clinical studies, diosmin reduced capacity venous stasis and venous volume (according plethysmography), reduced the average pressure in the superficial and deep veins of the legs (according to the Doppler ultrasound) and increased systolic and diastolic blood pressure in patients with postoperative orthostatic hypotension. Diosmin improves lymphatic drainage increases tone frequency and reduction of lymphatic capillaries, their functional density increases, reduces pressure lymph. Diosmin improves. In experimental studies, diosmin increased capillary resistance (dose-dependent effect) and reduced permeability in rats and guinea pigs with deficiency of vitamin F, and also reduced the capillary permeability induced by chloroform, histamine and hyaluronidase. Diosmin reduces the adhesion of leukocytes to the venous wall and their migration into tissues paravenoznye, improves oxygen diffusion and perfusion in the cutaneous tissue. In experimental studies, diosmin anti-inflammatory effect by blocking the production of free radicals, prostaglandins and thromboxane.
Conditions of supply of pharmacies
Without a prescription.
Dosing and Administration
The drug is intended for oral administration. Varicose veins of the lower limbs and chronic lymphovenous failure: the drug is prescribed 1 tablet per day in the morning on an empty stomach. Duration of therapy is usually 2 months. In severe forms of chronic lymphovenous insufficiency (edema, pain, convulsion, etc.), treatment may be longer (the total duration of continuous therapy should not exceed three to four months). Courses of treatment Flebofa repeated after 2-3 months. during the II and III trimester of pregnancy drug to treat chronic lymphovenous failure appoint 1 tablet 1 time a day. You need to stop taking the drug for 2-3 weeks before delivery. During exacerbation of hemorrhoids: the drug is prescribed 2-3 tablets a day with meals for 7 days. Then you can continue taking the drug if necessary to 1 tablet 1 time a day for 1-2 months. When violations of the microcirculation: the drug is prescribed 1 tablet per day in the morning on an empty stomach. Duration of therapy is usually 1-2 months. If you missed one or more steps of the preparation, you must continue to use the drug in normal mode and in a normal dose.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist