Fexofenadine-quinacrine tab n / 120mg film about 10 pc

Description

Composition
Active substance:
Fexofenadine hydrochloride, calculated as 100% substance – 120 mg.
Excipients:
Lactose monohydrate – 82.6 mg pregelatinized starch – 12 mg, giproloza – 5 mg Sodium carboxymethyl starch – 14.4 mg Sodium lauryl sulfate – 1.2 mg Colloidal silicon dioxide – 2.4 mg magnesium stearate – 2.4 mg.
Description:
Tablets, film-coated, from yellow-pink to yellow-brownish pink color, round, biconvex. At the turn of tablets from white to white with grayish or yellowish tint.
Product form:
Tablets, film-coated, 120 mg
10 tablets in blisters of PVC film and aluminum foil. 1 or 3 blisters for tablets with a dosage of 120 mg together with instructions for use placed in a pile of cardboard.
Contraindications
Hypersensitivity to any component of the drug; lactase deficiency, lactose intolerance, glucose-galactose malabsorption; Children up to age 12 years; Pregnancy and breast-feeding.
Carefully
Chronic renal failure, liver failure, advanced age, serdechno¬sosudistye disease (disorder).
Dosage
120 mg
Indications
• seasonal allergic rhinitis (120 mg tablets). • Chronic idiopathic urticaria (to reduce symptoms) (180 mg tablets).
Interaction with other drugs
Or combined with ketoconazole or erythromycin fexofenadine plasma concentration increases by 2-3 times, due, apparently, with increasing absorption in the gastrointestinal tract and the reduction or elimination of bile or gastrointestinal secretion (not accompanied by increased side effects ).
Antacids containing aluminum or magnesium, for 15 minutes before receiving fexofenadine leads to decrease in bioavailability.
Fexofenadine does not interact with omeprazole, a drug, metaboliziruyu- schimisya in the liver.
Overdose
Symptoms: dizziness, drowsiness, dry mouth.
Treatment: gastric lavage, appointment of activated charcoal, laxatives. Recommended symptomatic and supportive therapy. Hemodialysis is ineffective.
pharmachologic effect
Pharmacological group:
Antiallergic agent – H1-histamine receptor blocker.
Pharmacodynamics:
Antihistamine, a pharmacologically active metabolite of terfenadine. Blocks H1-histamine receptors and membrane stabilizes mast cells, reduces the release of histamine from these and other biologically active substances. No anticholinergic and alpha-1-adrenoceptor blocking action; It does not pass through the blood-brain barrier. Antihistaminic effect occurs within 1 h after oral administration, reaching a peak after 6 hours and continued for 24 hours.
Pharmacokinetics:
After ingestion is rapidly absorbed from the gastrointestinal tract, the time to reach maximum concentration (Tmax) in the blood plasma after ingestion – 1-3 h Mean value of maximum concentration (Cmax) in the blood plasma after administration of 120 mg per day of about 289 ng. / mL, after receiving 180 mg – about 494 ng / ml. Binding to plasma proteins – 60-70%. The half-life (T1 / 2) after multiple dose – 11-15 hours.
It is metabolized about 5% of the dose. Derived predominantly (80%) in the bile, 10% – kidneys unchanged.
Fexofenadine pharmacokinetics in single and course intake (up to 120 mg twice daily) is linear. After oral administration at a dose of 240 mg 2 times daily observed proportional increase in the area of ​​the curve “concentration-time» (AUC) (8,8%).
Pregnancy and breast-feeding
Use of the drug fexofenadine-Akrikhin contraindicated in pregnancy and during breastfeeding.
If necessary, use during lactation, breast-feeding should be discontinued.
Conditions of supply of pharmacies
Without recipe.
side effects
The frequency of side effects is classified in accordance with the recommendations of the World Health Organization (WHO): very common (> 10%); often (> 1%, 0.1%, 0.01%,
From the nervous system: often – headache, drowsiness, dizziness.
Gastro-intestinal tract: often – nausea.
Skin and subcutaneous tissue disorders: rarely – rash.
Other: often – fatigue; rarely – weakness.
Post-marketing study (the frequency is unknown)
Immune system: hypersensitivity reactions (angioedema, difficulty breathing, dyspnea, flushing of the skin, systemic anaphylactic reactions).
From the nervous system and psyche: insomnia, nervousness, sleep disturbances, nightmares.
Cardio-vascular system: tachycardia, palpitations.
On the part of the gastrointestinal tract: diarrhea.
Skin and subcutaneous tissue disorders: rash, urticaria, pruritus.
If any of these instructions side effects are compounded, or if you notice any other side effects not mentioned in the instructions, tell your doctor.
special instructions
It is recommended that the time interval between reception of fexofenadine and antacids containing aluminum or magnesium, was at least 2 hr.
The effect on the ability of control of vehicles and mechanisms
If you are taking the drug fexofenadine-Akrikhin patients experienced side effects such as drowsiness, dizziness, should avoid the performance of potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
In a dry, dark place at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Inside, adults and children over 12 years.
By seasonal allergic rhinitis recommended dose is 1 120 mg once a day before meals.
In chronic idiopathic urticaria (to reduce symptoms), the recommended dose is 1 180 mg once a day before meals.
Specific categories of patients
Elderly patients, patients with impaired kidney function and liver dose adjustment is required.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist