Ferrum lek Injection 100mg / 2ml amp 2ml 5 pcs

$33.19

Ferrum lek Injection 100mg / 2ml amp 2ml 5 pcs

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Description

Composition
Active substance:
1 ampoule (2 ml) contains:
Iron (III) complex in the form of iron (III) hydroxide-dextran – 100 mg ;.
Excipients:
Water for injections.
to adjust the pH of the solution using sodium hydroxide as a 6 M solution of hydrochloric acid or conc.
Description:
The brown cloudy solution is practically free of any visible particles.
Product form:
2 ml of the product in a glass vial (hydrolytic class I) c fracture point of red color. At the top of the vial – red ring.
5 or 10 vials were placed in an open blister made of PVC or PVC blister, film covered termolakirovannoy. 1 or 2 to 5 blister ampoules or blisters 1 or 5 to 10 vials were placed in a cardboard box, together with instructions for use.
Contraindications
Increased sensitivity to the drug; excess body iron (hemochromatosis, hemosiderosis); anemia not associated with iron deficiency (e.g., hemolytic anemia); breach mechanisms “recycling” of iron (lead anemia, sideroahrestical anemia, thalassemia); first trimester of pregnancy; Osler-Rendu-Weber syndrome; infectious diseases of the kidneys in the acute stage; uncontrolled hyperparathyroidism; decompensated cirrhosis; infectious hepatitis.
Precautions: asthma, allergic eczema or other atopic allergy; chronic polyarthritis; heart failure; Low ability to bind iron and / or folate deficiency; Children up to age 4 months.
Dosage
50 mg / ml
Indications
Treatment of all forms of iron deficiency states in which it is necessary the rapid replenishment of iron stores, including the following: severe iron deficiency due to blood loss; impaired iron absorption in the intestine; states in which iron preparations for oral treatment ineffective or impractical.
Interaction with other drugs
It should not be used concurrently with oral iron supplements. Simultaneous administration of ACE inhibitors may cause enhanced systemic effects of parenteral iron preparations.
Overdose
Overdosing can lead to a severe overload of iron and hemosiderosis. Treatment is symptomatic; as an antidote is administered by slow intravenous injection (15 mg / kg / hour) deferoxamine depending upon overdose of gravity, but not more than 80 mg / kg per day. Hemodialysis is ineffective.
pharmachologic effect
Pharmacological group:
Antanemic. Iron preparation.
Pharmacodynamics:
The preparation contains iron as ferric iron complex of ferric hydroxide with a dextran. Iron, which is part of the drug quickly compensates for the deficiency of this element in the body (especially in iron deficiency anemia), restores hemoglobin. In drug treatment, there is a gradual reduction in both clinical symptoms (weakness, fatigue, dizziness, tachycardia, pain and dryness of the skin) and laboratory parameters of iron deficiency.
Pharmacokinetics:
After intramuscular injection of iron quickly enters the bloodstream 15% of the dose – 15 min, 44% – 30 min. The biological half-life of 3-4 days. Iron in complex with transferrin transferred to the cells of the body, where it is used for the synthesis of hemoglobin, myoglobin and certain enzymes. Complex iron hydroxide (III) dextran is sufficiently large and therefore is not output through the kidneys.
Pregnancy and breast-feeding
The drug is contraindicated in the first trimester of pregnancy. In the second and third trimesters of pregnancy and in breast-feeding during the use of the drug is possible only if the expected benefit to the mother outweighs the potential harm to the fetus or infant.
Conditions of supply of pharmacies
On prescription.
side effects
By the immune system
Anaphylactoid reactions including wheezing, hives, rashes, itching, nausea and shivering, acute severe anaphylactoid reactions (difficulty in breathing, circulatory collapse) with a fatal outcome. It is also possible the development of delayed reactions (arthralgia, myalgia, fever). From the nervous system
Loss of consciousness, convulsions, dizziness, headache, paresthesia, taste perversion.
Cardio-vascular system
Arrhythmia, tachycardia, palpitations, marked reduction / increased blood pressure.
The respiratory system
Bronchospasm, dyspnea.
From the digestive system
Dyspepsia (including nausea, vomiting), abdominal pain, diarrhea.
Skin and subcutaneous tissue disorders
Itching, hives, rash, angioedema, excessive sweating.
On the part of the musculoskeletal and connective tissue
Cramps, myalgia, arthralgia.
With the genitourinary system
Chromaturia (discoloration of urine).
General disorders and injection site
Chills, “tides” of blood to the face, chest pain, swollen lymph nodes, fever, fatigue. In place of intramuscular injections (usually due to violation of the art injection) – skin staining, bleeding, formation of sterile abscesses, tissue necrosis or atrophy, pain.
special instructions
Use only in a hospital environment.
In applying the drug Ferrum Lek® required laboratory testing: the total blood count and determination of serum ferritin; It is necessary to eliminate impaired iron absorption.
Ferrum Lek® drug is intended for intramuscular administration. Technique administration: obligatory introduction deep into the gluteal muscle (needle length of 5-6 cm), and the shifting of the tissues during insertion of the needle and tissue compression after removal of the needle; introduced one by one in the right and left gluteus muscles. The opened ampoule should be used immediately. Parenterally administered iron preparations can cause hypersensitivity reactions including anaphylactoid reactions, which can be potentially life-threatening, therefore, should be available to the appropriate means to carry out cardiopulmonary resuscitation.
The risk of anaphylactoid reactions is increased in patients with a history of allergy (including drug), patients with severe bronchial asthma, a history of eczema or other allergic manifestations, as well as in patients with immune-inflammatory diseases of the patient (eg, systemic lupus erythematosus, rheumatoid arthritis).
In patients with impaired liver function application parenteral iron should be administered only after careful evaluation benefit / risk ratio. Parenteral administration of iron should be avoided in patients with impaired liver function, wherein iron overload may be the pathogenetic factor of adverse events (including porphyria cutanea tarda). Recommended careful monitoring of the concentration of iron. The contents of ampoules of the drug Ferrum Lek® should not be mixed with other drugs. Treatment with oral forms of iron-containing preparations should be started no earlier than 5 days after the last injection Ferrum Lek®. At improper storage of the drug may precipitate, using such ampoules unacceptable.
Storage conditions
At a temperature not exceeding 25 C. Do not freeze.
Keep out of the reach of children.
Dosing and Administration
The drug is Ferrum Lek® solution is only intended for intramuscular administration. The drug should be administered only in a hospital, by trained staff who know how to recognize the signs beginning anaphylactic shock, in terms of availability of funds and the possibility of resuscitation complex antishock measures. The patient should be observed for at least 30 minutes after each injection. Before administration of the first therapeutic dose for each patient should introduce a test dose is 1 / 4-1 / 2 of the ampoule preparation Lek® Ferrum (25 – 50 mg of iron) for adults and half the daily dose for children. In the absence of side reactions during the 15 minutes should enter the remainder of the daily dose.
Ferrum Lek® dose should be selected individually in accordance with a common iron deficiency, which is calculated by the following formula:
Total iron deficiency [mg] = body weight (kg) x (the estimated level of hemoglobin (g / L) – the actual level of hemoglobin (g / l)) x + 0.24 * iron deposited (mg).
Body weight up to 35 kg: calculated level of Hb = 130 g / l and deposited iron = 15 mg / kg body weight.
body weight over 35 kg: calculated level of Hb = 150 g / l and deposited iron = 500 mg. * Factor: 0.0034 x 0.24 = 0.07 x 1000: (iron content = 0.34%; total blood volume = 7% of body weight; 1000 = factor translating from g / l mg / l).
Example:
Patient body weight: 70 kg
The actual hemoglobin concentration: 80 g / l
The total deficit of iron = 70 x (150 – 80) x 0.24 + 500 = 1676 -1700 mg iron.
Total number of ampules Ferrum Lek® drug to be administered = Total iron deficiency (mg) / 100 mg
If necessary dose Ferrum Lek® drug exceeds the maximum daily dose, drug administration should be a fraction (a few days).
If after 1-2 weeks of treatment of hematologic parameters do not change, it is necessary to conduct additional tests to clarify the diagnosis.
Calculate the total dose to compensate the iron due to blood loss
The required amount of drug to compensate for hemorrhagic zhelezodefitsita calculated by the following formula:
If a known amount of blood lost: administering 200 mg intramuscularly (2 ampoules Ferrum Lek® preparation) leads to an increase in hemoglobin concentration, which is equivalent to one unit of blood (400 ml blood with a hemoglobin content of 150 g / l).
Iron, which should compensate (mg) = number of lost blood units x 200 or required number of vials of drug Ferrum Lek® = number of lost blood units 2. If x is known final hemoglobin: Use the following equation, given that the deposited iron does not need to reimburse .
Iron, which should compensate (mg) = body weight (kg) x (the estimated level of hemoglobin (g / L) – the actual level of hemoglobin (g / l)) x 0.24.
Example:
A patient with a body weight of 60 kg and a deficit in hemoglobin to 10 g / l should reimburse 150 mg of iron that is 1 1/2 ampoule preparation Ferrum Lek®.
standard doses
Babies: 0.06 ml / kg body weight / day (3 mg iron / kg / day).
Adults: 1 – 2 ampoules Ferrum Lek® preparation (100 – 200 mg iron) depending on the hemoglobin.
The maximum daily dose
Babies: 0.14 ml / kg body weight per day (7 mg iron / kg / day).
Adults: 4 ml (2 ampoules Ferrum Lek® drug) per day.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Sandoz RX

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