Famotidine tab n / 40mg film about 20 pieces of ozone

Description

Composition
Active substance:
1 tablet contains: famotidine 20 or 40 mg.
Product form:
20 mg of 20 and 30 tablets in a contour packaging, 40 mg of 20 tablets in a contour packaging.
Contraindications
Pregnancy and lactation, infancy, hepatic insufficiency, hypersensitivity to the drug.
Dosage
40 mg
Indications
Treatment and prevention of relapse of gastric ulcer and duodenal ulcers, treatment and prevention of gastric symptomatic ulcers and duodenal ulcers (associated with taking NSAIDs, stress, postoperative), erosive gastroduodenitis, functional dyspepsia, associated with increased secretion of the stomach, reflux esophagitis, Zollinger -Ellisona, prevention of recurrence of bleeding of upper gastrointestinal tract, prevention of aspiration of gastric juice under general anesthesia (Mendelso syndrome a).
pharmachologic effect
Pharmacological group:
Histamine H2-receptor blocker.
Pharmacodynamics:
Blocker histamine H2 receptor III generation. Inhibits basal and stimulated by histamine, gastrin and acetylcholine production of hydrochloric acid. Reduces the activity of pepsin. Enhances the protective mechanisms of gastric mucosa and promote healing associated with exposure to hydrochloric acid her lesions (in t. H. Cessation of gastrointestinal bleeding and scarring stress ulcers) by increasing the formation of gastric mucosa, its content of glycoproteins, stimulation of secretion of bicarbonate gastric mucosa, endogenous synthesis of prostaglandins in it and regenerating rate.
It did not significantly alter the concentration of gastrin in plasma. Low oxy- daznuyu inhibits cytochrome P450 system in the liver.
After ingestion action starts after 1 hour reaches the maximum within 3 hours. Duration of the pre Paratov in single intake dose-dependent and ranges from 12 to 24 hours.
Pharmacokinetics:
After intake of rapidly absorbed from the gastrointestinal tract. After ingestion time to reach maximum plasma concentration (TSmax) 1-3.5 hours Bioavailability -. 40-45% increases when taken with food and lowered the intake of antacids. Relationship to plasma proteins – 15-20%. Famotidine 30-35% metabolized in the liver (to form S-oxide). Elimination mainly occurs via the kidneys: 27-40% of the drug excreted in the urine unchanged. The half – 2.5-4 hours, in patients with a creatinine clearance less than 30 mL / min is increased to 10-12 hours. In patients with severe renal failure (creatinine clearance less than 10 mL / min), it increased to 20 hours. It crosses the placental barrier and is excreted in breast milk.
Conditions of supply of pharmacies
Prescription.
Dosing and Administration
Inside, gastric ulcer and duodenal ulcer exacerbation, erosive gastroduodenitis 40 mg at bedtime or 20 mg of 2 times / day (morning and evening), if necessary, the daily dose may be increased to 80-160 mg, duration of the course – 4-8 weeks; for the prevention of exacerbations – 20 mg 1 time a day at night. When reflux esophagitis – 20-40 mg 2 times a day for 6-12 weeks, Zollinger-Ellison syndrome – the dose and duration of treatment is determined individually.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist